Effect of Insulin Dilution on Lowering Glycemic Variability in Pump-Treated Young Children with Inadequately Controlled Type 1 Diabetes

2015 ◽  
Vol 17 (9) ◽  
pp. 605-610 ◽  
Author(s):  
Beata Mianowska ◽  
Wojciech Fendler ◽  
Bartłomiej Tomasik ◽  
Wojciech Młynarski ◽  
Agnieszka Szadkowska
Author(s):  
Alexandra D Monzon ◽  
Arwen M Marker ◽  
Amy E Noser ◽  
Mark A Clements ◽  
Susana R Patton

Abstract Background Young children with Type 1 diabetes (T1D) are at risk for extreme blood glucose variability, a risk factor for suboptimal glycated hemoglobin A1c (HbA1c) and long-term health complications. We know that a reciprocal relationship exists between sleep and glycemic outcomes in older youth with T1D; however, little research has examined objective sleep in young children (<7 years) with T1D. Purpose This study examines bidirectional associations between sleep behaviors and glycemic variability in young children with T1D. Methods Thirty-nine young children with T1D (Mage 4.33 ± 1.46 years; MHbA1c 8.10 ± 1.06%) provided accelerometry data to objectively measure sleep onset latency, number of nighttime awakenings, and total sleep time. We also assessed HbA1c, average blood glucose, and glycemic variability (i.e., standard deviation of blood glucose from device downloads). We evaluated bidirectional relationships using multilevel modeling in SAS, with weekday/weekend as a Level 2 moderator. Results Children averaged 8.5 ± 1.44 hr of sleep per night, but only 12.8% met current sleep recommendations. Children experienced more nighttime awakenings, higher blood glucose, and more glycemic variability on weekends. Sleep onset latency and nighttime awakenings predicted greater glycemic variability on weekends, and weekend glycemic variability predicted increased nighttime awakenings. Conclusions Most young children with T1D did not meet sleep recommendations. Young children experienced more nighttime awakenings, higher blood glucose, and increased glycemic variability on weekends only, when routines may be less predictable. Findings suggest that one way families of young children with T1D may be able to decrease glycemic variability is to keep consistent routines on weekdays and weekends.


2018 ◽  
Author(s):  
A Emile J Hendriks ◽  
Ross L Ewen ◽  
Yoke Sin Hoh ◽  
Nazia Bhatti ◽  
Rachel M Williams ◽  
...  

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Gimeno Sergio Roman ◽  
Peteiro Miranda Carlos Miguel ◽  
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Ana Agudo ◽  
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Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1368-P ◽  
Author(s):  
ROWEN L. SECKOLD ◽  
PETER HOWLEY ◽  
BRUCE R. KING ◽  
KIRSTINE BELL ◽  
CARMEL E. SMART

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1278-P
Author(s):  
IMAN AL-GADI ◽  
RANDI STREISAND ◽  
MAUREEN MONAGHAN ◽  
CARRIE TULLY ◽  
MANUELA SINISTERRA ◽  
...  

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 890-P
Author(s):  
DANIEL DESALVO ◽  
LAUREN KANAPKA ◽  
COLLEEN BAUZA ◽  
CICILYN XIE ◽  
LINDA DIMEGLIO ◽  
...  

2018 ◽  
Vol 14 (4) ◽  
pp. 395-403 ◽  
Author(s):  
Karem Mileo Felício ◽  
Ana Carolina Contente Braga de Souza ◽  
Joao Felicio Abrahao Neto ◽  
Franciane Trindade Cunha de Melo ◽  
Carolina Tavares Carvalho ◽  
...  

Diabetes Care ◽  
2002 ◽  
Vol 25 (2) ◽  
pp. 313-318 ◽  
Author(s):  
S. W. Powers ◽  
K. C. Byars ◽  
M. J. Mitchell ◽  
S. R. Patton ◽  
D. A. Standiford ◽  
...  

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