Photodynamic Inactivation of Enveloped Viruses: Potential Application for Blood Banking

1990 ◽  
Vol 8 (4) ◽  
pp. 49-52 ◽  
Author(s):  
Millard M. Judy
Author(s):  
Millard M. Judy ◽  
Joseph T. Newman ◽  
James L. Matthews ◽  
Franklin Sogandares-Bernal ◽  
Helen Skiles ◽  
...  

2019 ◽  
Vol 23 (09) ◽  
pp. 1041-1046 ◽  
Author(s):  
Giovana Basso ◽  
Juliana F. Cargnelutti ◽  
Amanda L. Oliveira ◽  
Thiago V. Acunha ◽  
Rudi Weiblen ◽  
...  

Porphyrin-based photodynamic processes have been used for the inactivation of microorganisms and treatment of tumors. The virucidal activity of porphyrins 3-PtTPyP and 4-PtTPyP was investigated against bovine viruses representative of the main structural groups (enveloped/non-enveloped, DNA/RNA: BVDV, BoHV-1, BAV and BEV), and against two epitheliotropic viruses (VSV and VACV). Viral suspensions were incubated at 0.91 [Formula: see text]mol [Formula: see text] L[Formula: see text] and exposed to a white-light LED array source (25 mW [Formula: see text] cm[Formula: see text]; 90 J [Formula: see text] cm[Formula: see text] for 0, 15, 30 and 60 min followed by determination of the remaining virus titers. Porphyrin 3-PtTPyP reduced almost 6 log of VSV and 3.5 log of BVDV titers after 15 min and complete virus photoinactivation was achieved after 30 min. 4-PtTPyP at 0.91 [Formula: see text]mol [Formula: see text] L[Formula: see text] produced reduction of titers of all enveloped virus depending on the time of light irradiation. No virucidal activity of any of the porphyrins was observed for non-enveloped viruses and these results showed the potential of porphyrins to inactivate viruses in premises.


1988 ◽  
Vol 1 (2) ◽  
pp. 2-14 ◽  
Author(s):  
Joseph T. Newman ◽  
James L. Matthews ◽  
Franklin Sogandares-Bernal ◽  
Millard M. Judy ◽  
Helen Skiles ◽  
...  

1992 ◽  
Author(s):  
Millard M. Judy ◽  
James Lester Matthews ◽  
Franklin M. Sogandares-Bernal ◽  
Joseph T. Newman ◽  
Tran C. Chanh ◽  
...  

2009 ◽  
Vol 00 (00) ◽  
pp. 090513010017019-7
Author(s):  
Biagio Solarino ◽  
Giancarlo Di Vella ◽  
Thea Magrone ◽  
Felicita Jirillo ◽  
Angela Tafaro ◽  
...  

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