Targeting Gastrointestinal Stromal Tumor with 68Ga-Labeled Peptides: An In Vitro Study on Gastrointestinal Stromal Tumor-Cell Lines

2016 ◽  
Vol 31 (8) ◽  
pp. 302-310 ◽  
Author(s):  
Achim Paulmichl ◽  
Dominik Summer ◽  
Claudia Manzl ◽  
Christine Rangger ◽  
Francesca Orlandi ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Gastrointestinal Stromal Tumor ◽  
Cell Lines ◽  
In Vitro Study ◽  
Vitro Study ◽  
Stromal Tumor ◽  
Tumor Cell Lines

Preliminary In-vitro Study of 223Ra Impact on Selected Tissue and Tumor Cell Lines

2019 ◽  
Vol 50 (4) ◽  
pp. S114
Author(s):  
Lukas Ondrák ◽  
Martin Vlk ◽  
Jan Kozempel ◽  
Marie Davidkova ◽  
Jana Vachelova
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
In Vitro Study ◽  
Vitro Study ◽  
Tumor Cell Lines

scholarly journals Preliminary In-vitro Study of 223Ra Impact on Selected Tissue and Tumor Cell Lines

2019 ◽  
Vol 50 (1) ◽  
pp. S41-S42
Author(s):  
Lukas Ondrák ◽  
Martin Vlk ◽  
Jan Kozempel ◽  
Marie Davidkova ◽  
Jana Vachelova
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
In Vitro Study ◽  
Vitro Study ◽  
Tumor Cell Lines

Effects of imatinib vary with the types of KIT-mutation in gastrointestinal stromal tumor cell lines

2005 ◽  
Author(s):  
Kazuhiro Noma ◽  
Yoshio Naomoto ◽  
Mehmet Gunduz ◽  
Junji Matsuoka ◽  
Tomoki Yamatsuji ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Gastrointestinal Stromal Tumor ◽  
Cell Lines ◽  
Stromal Tumor ◽  
Tumor Cell Lines ◽  
Kit Mutation

scholarly journals Potentiation of imatinib by cilostazol in sensitive and resistant gastrointestinal stromal tumor cell lines involves YAP inhibition

Oncotarget ◽  
2019 ◽  
Vol 10 (19) ◽  
pp. 1798-1811 ◽  
Author(s):  
Pierre Vandenberghe ◽  
Marine Delvaux ◽  
Perrine Hagué ◽  
Christophe Erneux ◽  
Jean-Marie Vanderwinden
Keyword(s):  
Tumor Cell ◽  
Gastrointestinal Stromal Tumor ◽  
Cell Lines ◽  
Stromal Tumor ◽  
Tumor Cell Lines

Cellular Uptake of the Tyrosine Kinase Inhibitors Imatinib and AMN107 in Gastrointestinal Stromal Tumor Cell Lines

Pharmacology ◽  
2006 ◽  
Vol 77 (1) ◽  
pp. 11-16 ◽  
Author(s):  
Hans Prenen ◽  
Gunther Guetens ◽  
Gert de Boeck ◽  
Maria Debiec-Rychter ◽  
Paul Manley ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Tumor Cell ◽  
Gastrointestinal Stromal Tumor ◽  
Tyrosine Kinase Inhibitors ◽  
Cell Lines ◽  
Cellular Uptake ◽  
Kinase Inhibitors ◽  
Stromal Tumor ◽  
Tumor Cell Lines

Effect of black seeds (Nigella sativa) volatile oil on the cervical cancer: In vitro study, on Hela cell lines

2019 ◽  
Vol 7 (4) ◽  
pp. 91-96
Author(s):  
Isra'a Al-sobhi ◽  
◽  
Rawan Al-Ghabban ◽  
Soad Shaker Ali ◽  
Jehan Al-Amri ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Hela Cell ◽  
Cell Lines ◽  
Nigella Sativa ◽  
In Vitro Study ◽  
Volatile Oil ◽  
Vitro Study ◽  
Hela Cell Lines ◽  
Black Seeds

Synthesis and Cytotoxicity of New Mannich Bases of 6-[3-(3,4,5-Trimetoxyphenyl)-2- propenoyl]-2(3H)-Benzoxazolone

2020 ◽  
Vol 17 (4) ◽  
pp. 512-517
Author(s):  
Ognyan Ivanov Petrov ◽  
Yordanka Borisova Ivanova ◽  
Mariana Stefanova Gerova ◽  
Georgi Tsvetanov Momekov
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Biological Activities ◽  
Human Tumor ◽  
Mannich Bases ◽  
In Vitro Cytotoxicity ◽  
Tumor Cell Lines ◽  
Human Tumor Cell ◽  
Human Tumor Cell Lines

Background: Chemotherapy is one of the mainstays of cancer treatment, despite the serious side effects of the clinically available anticancer drugs. In recent years increasing attention has been directed towards novel agents with improved efficacy and selectivity. Compounds with chalcone backbone have been reported to possess various biological activities such as anticancer, antimicrobial, anti-inflammatory, analgesic, antioxidant, etc. It was reported that aminomethylation of hydroxy chalcones to the corresponding Mannich bases increased their cytotoxicity. In this context, our interest has been focused on the design and synthesis of the so-called multi-target molecules, containing two or more pharmacophore fragments. Methods: A series of Mannich bases were synthesized by the reaction between 6-[3-(3,4,5- trimethoxyphenyl)-2-propenoyl]-2(3Н)-benzoxazolone, formaldehyde, and a secondary amine. The structures of the compounds were confirmed by elemental analysis, IR and NMR spectra. The new Mannich bases were evaluated for their in vitro cytotoxicity against a panel of human tumor cell lines, including BV-173, SKW-3, K-562, HL-60, HD-MY-Z and MDA-MB-231. The effects of selected compounds on the cellular levels of glutathione (GSH) were determined. Results: The new compounds 4a-e exhibited concentration-dependent cytotoxic effects at micromolar concentrations in MTT-dye reduction assay against a panel of human tumor cell lines, similar to those of starting chalcone 3. The tested agents led to concentration - dependent depletion of cellular GSH levels, whereby the effects of the chalcone prototype 3 and its Mannich base-derivatives were comparable. Conclusion: The highest chemosensitivity to the tested compounds was observed in BV- 173followed by SKW-3 and HL-60 cell lines.

Sign in / Sign up

Export Citation Format

Share Document