Weight Gain Effects of Second-Generation Antipsychotic Treatment in Autism Spectrum Disorder

2016 ◽  
Vol 26 (9) ◽  
pp. 822-827 ◽  
Author(s):  
Yesie Yoon ◽  
Logan K. Wink ◽  
Ernest V. Pedapati ◽  
Paul S. Horn ◽  
Craig A. Erickson
Keyword(s):  
Autism Spectrum Disorder ◽  
Weight Gain ◽  
Second Generation ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Antipsychotic Treatment ◽  
Second Generation Antipsychotic

scholarly journals Risk Factors for Unhealthy Weight Gain and Obesity among Children with Autism Spectrum Disorder

2019 ◽  
Vol 20 (13) ◽  
pp. 3285 ◽  
Author(s):  
Khushmol K. Dhaliwal ◽  
Camila E. Orsso ◽  
Caroline Richard ◽  
Andrea M. Haqq ◽  
Lonnie Zwaigenbaum
Keyword(s):  
Risk Factors ◽  
Autism Spectrum Disorder ◽  
Weight Gain ◽  
Autism Spectrum ◽  
Lifestyle Factors ◽  
Repetitive Behaviors ◽  
Spectrum Disorder ◽  
Future Research ◽  
Children With Asd ◽  
Unhealthy Weight

Autism Spectrum Disorder (ASD) is a developmental disorder characterized by social and communication deficits and repetitive behaviors. Children with ASD are also at a higher risk for developing overweight or obesity than children with typical development (TD). Childhood obesity has been associated with adverse health outcomes, including insulin resistance, diabetes, heart disease, and certain cancers. Importantly some key factors that play a mediating role in these higher rates of obesity include lifestyle factors and biological influences, as well as secondary comorbidities and medications. This review summarizes current knowledge about behavioral and lifestyle factors that could contribute to unhealthy weight gain in children with ASD, as well as the current state of knowledge of emerging risk factors such as the possible influence of sleep problems, the gut microbiome, endocrine influences and maternal metabolic disorders. We also discuss some of the clinical implications of these risk factors and areas for future research.

scholarly journals Early life influences on child weight outcomes in the Study to Explore Early Development

Autism ◽  
2018 ◽  
Vol 23 (4) ◽  
pp. 954-962
Author(s):  
Tanja VE Kral ◽  
Jesse Chittams ◽  
Chyrise B Bradley ◽  
Julie L Daniels ◽  
Carolyn G DiGuiseppi ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Autism Spectrum Disorder ◽  
Weight Gain ◽  
Confidence Interval ◽  
Gestational Weight Gain ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Rapid Weight Gain ◽  
Gestational Weight

We examined associations between child body mass index at 2–5 years and maternal pre-pregnancy body mass index, gestational weight gain, and rapid weight gain during infancy in children with autism spectrum disorder, developmental delays, or population controls. The Study to Explore Early Development is a multi-site case–control study of children, aged 2–5 years, classified as autism spectrum disorder ( n = 668), developmental delays ( n = 914), or population controls ( n = 884). Maternal gestational weight gain was compared to the Institute of Medicine recommendations. Rapid weight gain was a change in weight-for-age z-scores from birth to 6 months > 0.67 standard deviations. After adjusting for case status, mothers with pre-pregnancy overweight/obesity were 2.38 times (95% confidence interval: 1.96–2.90) more likely, and mothers who exceeded gestational weight gain recommendations were 1.48 times (95% confidence interval: 1.17–1.87) more likely, to have an overweight/obese child than other mothers ( P < 0.001). Children with autism spectrum disorder showed the highest frequency of rapid weight gain (44%) and were 3.47 times (95% confidence interval: 1.85–6.51) more likely to be overweight/obese as children with autism spectrum disorder without rapid weight gain ( P < 0.001). Helping mothers achieve a healthy pre-pregnancy body mass index and gestational weight gain represent important targets for all children. Healthy infant growth patterns carry special importance for children at increased risk for an autism spectrum disorder diagnosis.

Case of paediatric catatonia precipitated by antipsychotic withdrawal in a child with autism spectrum disorder

2021 ◽  
Vol 14 (4) ◽  
pp. e240785
Author(s):  
Mohd Faisal ◽  
Vishnu Pradeep ◽  
Susan O'Hanrahan
Keyword(s):  
Autism Spectrum Disorder ◽  
Altered Mental Status ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Total Daily Dose ◽  
Antipsychotic Treatment ◽  
Disruptive Behaviour ◽  
High Dependency ◽  
Prolonged Duration ◽  
History Of

A 13-year-old girl with moderate intellectual disability and autism spectrum disorder (ASD) was admitted to the paediatric high-dependency unit following an 8-week history of altered mental status and motor behaviour. Her symptoms emerged followed shortly after discontinuation of risperidone, an atypical antipsychotic previously commenced to manage disruptive behaviour associated with ASD. On physical examination, the patient presented with negativism, grimacing, automatic obedience, waxy flexibility and ambitendency. Blood tests, neuroimaging and lumbar puncture failed to reveal an acute infectious or neurological precipitant. She responded immediately to a trial of intramuscular lorazepam titrated to a total daily dose of 12 mg. This case presents challenges of accurately diagnosing and managing catatonic symptoms in adolescent patients with ASD. We also discuss the potential risk of precipitating catatonia following the discontinuation of antipsychotic treatment that has been prescribed for a prolonged duration.

scholarly journals Prenatal Exposure to Diethylstilbestrol and Multigenerational Psychiatric Disorders: An Informative Family

2021 ◽  
Vol 18 (19) ◽  
pp. 9965
Author(s):  
Marie-Odile Soyer-Gobillard ◽  
Laura Gaspari ◽  
Françoise Paris ◽  
Nicolas Kalfa ◽  
Samir Hamamah ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Eating Disorders ◽  
Psychiatric Disorders ◽  
Second Generation ◽  
Psychiatric Symptoms ◽  
In Utero ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Informative Family ◽  
The Impact

Background: Psychiatric disorders in children exposed in utero to diethylstilbestrol (DES) are still debated. We report here the impact of DES prescribed to suppress lactation on the children born after such treatment and their progeny, focusing particularly on psychiatric disorders. Case presentation: We report here an informative family in which one or more psychiatric problems (e.g., bipolarity, suicide attempts and suicide, eating disorders) were detected in all children of second-generation (DES-exposed children; n = 9), but for II-2 who died at the age of 26 years due to rupture of a congenital brain aneurysm, and were associated with non-psychiatric disorders (particularly, endometriosis and hypospadias). In the third generation, 10 out of 19 DES-exposed grandchildren had psychiatric disorders (autism spectrum disorder, bipolar disorder, dyspraxia and learning disabilities, mood and behavioral disorders, and eating disorders), often associated with comorbidities. In the fourth generation (7 DES-exposed great-grandchildren, aged between 0 and 18 years), one child had dyspraxia and autism spectrum disorder. The first daughter of the second generation (not exposed to DES) and her children and grandchildren did not have any psychiatric symptoms or comorbidities. Conclusions: To our knowledge, the high prevalence of psychiatric disorders of various severities in two, and likely three generations, including DES-free pregnancies and DES-exposed pregnancies from the same family, has never been reported. This work strengthens the hypothesis that in utero exposure to DES contributes to the pathogenesis of psychiatric disorders. It also highlights a multigenerational, and possibly transgenerational, effect of DES in neurodevelopment and psychiatric disorders.

scholarly journals Maternal Pre-pregnancy Body Mass Index and Gestational Weight Gain in Relation to Autism Spectrum Disorder and other Developmental Disorders in Offspring

2018 ◽  
Vol 12 (2) ◽  
pp. 316-327 ◽  
Author(s):  
Gayle C. Windham ◽  
Meredith Anderson ◽  
Kristen Lyall ◽  
Julie L. Daniels ◽  
Tanja V.E. Kral ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Autism Spectrum Disorder ◽  
Weight Gain ◽  
Gestational Weight Gain ◽  
Body Mass ◽  
Developmental Disorders ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Gestational Weight

scholarly journals Response to Second Generation Antipsychotics in Youth with Comorbid Bipolar Disorder and Autism Spectrum Disorder

2010 ◽  
Vol 18 (1) ◽  
pp. 28-33 ◽  
Author(s):  
Gagan Joshi ◽  
Joseph Biederman ◽  
Janet Wozniak ◽  
Robert Doyle ◽  
Paul Hammerness ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Bipolar Disorder ◽  
Second Generation ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Second Generation Antipsychotics

scholarly journals 98 Monitoring the Safety of Second Generation Antipsychotics in Children and Adolescents with Autism Spectrum Disorder

2019 ◽  
Vol 24 (Supplement_2) ◽  
pp. e37-e38
Author(s):  
Jillian Filliter ◽  
Mikayla Kerr ◽  
Sarah Shea ◽  
Isabel Smith ◽  
Jillian MacCuspie ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Children And Adolescents ◽  
Second Generation ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Second Generation Antipsychotics ◽  
Adolescents With Autism

scholarly journals Associations between autism spectrum disorder and eating disorders with and without self-induced vomiting: an empirical study

2020 ◽  
Author(s):  
Noriko Numata ◽  
Akiko Nakagawa ◽  
Kazuko Yoshioka ◽  
Kayoko Isomura ◽  
Daisuke Matsuzawa ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Eating Disorders ◽  
Eating Disorder ◽  
Weight Gain ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Autism Spectrum Quotient ◽  
Essential Difference ◽  
Illness Duration ◽  
Significant Difference

Abstract Background: Although approximately 23% of anorexia nervosa (AN) patients have concomitant autism spectrum disorder (ASD), it is clinically difficult to determine ASD coexistence in patients with eating disorders. Restrictive AN is more common in younger patients and self-induced vomiting usually appears during adolescence/young adulthood with the collapse of control. Some patients state that they “would never want to vomit” and are tolerant of weight gain even if they start overeating. It is important to understand the essential difference between those who vomit and those who do not vomit. In this study, we hypothesised that the absence of self-induced vomiting may be associated with the presence of ASD and aimed to assess the presence of ASD tendencies in each eating disorder (EDs). Clarifying this association helps to consider the coexistence of ASD in the clinical setting and can lead to the next detailed ASD evaluation, and as a result, helps to determine the appropriate treatment and support individually.Methods: We retrospectively evaluated 43 females aged 15–45 years who attended Chiba University Hospital between 2012 and 2016 using the Eating Disorder Examination Questionnaire(EDE-Q) and Autism Spectrum Quotient (AQ) to quantify the severity of the eating disorder and to identify whether ASD tendency were present. Results: There was no difference in the AQ score between binging-purging type AN and restricting type AN. However, there was significant difference in the AQ score between bulimia nervosa and binge eating disorder (BED). Of the 4 ED subtypes, BED had the highest ASD tendency. The non-vomiting group with illness duration <4 years had a significantly higher AQ communication score than the vomiting group with illness duration ≥ 4 years.Conclusions: There was a difference in the AQ score by the presence or absence of self-induced vomiting. The present results may help us understand why those with BED do not vomit even if they gain weight and why BED is admissive even if there is weight gain. Thus, evaluation of patients for the absence of self-induced vomiting while assessing them for EDs may help us to understand the association with ASD tendencies.

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