scholarly journals Maternal Pre-pregnancy Body Mass Index and Gestational Weight Gain in Relation to Autism Spectrum Disorder and other Developmental Disorders in Offspring

2018 ◽  
Vol 12 (2) ◽  
pp. 316-327 ◽  
Author(s):  
Gayle C. Windham ◽  
Meredith Anderson ◽  
Kristen Lyall ◽  
Julie L. Daniels ◽  
Tanja V.E. Kral ◽  
...  
Autism ◽  
2018 ◽  
Vol 23 (4) ◽  
pp. 954-962
Author(s):  
Tanja VE Kral ◽  
Jesse Chittams ◽  
Chyrise B Bradley ◽  
Julie L Daniels ◽  
Carolyn G DiGuiseppi ◽  
...  

We examined associations between child body mass index at 2–5 years and maternal pre-pregnancy body mass index, gestational weight gain, and rapid weight gain during infancy in children with autism spectrum disorder, developmental delays, or population controls. The Study to Explore Early Development is a multi-site case–control study of children, aged 2–5 years, classified as autism spectrum disorder ( n = 668), developmental delays ( n = 914), or population controls ( n = 884). Maternal gestational weight gain was compared to the Institute of Medicine recommendations. Rapid weight gain was a change in weight-for-age z-scores from birth to 6 months > 0.67 standard deviations. After adjusting for case status, mothers with pre-pregnancy overweight/obesity were 2.38 times (95% confidence interval: 1.96–2.90) more likely, and mothers who exceeded gestational weight gain recommendations were 1.48 times (95% confidence interval: 1.17–1.87) more likely, to have an overweight/obese child than other mothers ( P < 0.001). Children with autism spectrum disorder showed the highest frequency of rapid weight gain (44%) and were 3.47 times (95% confidence interval: 1.85–6.51) more likely to be overweight/obese as children with autism spectrum disorder without rapid weight gain ( P < 0.001). Helping mothers achieve a healthy pre-pregnancy body mass index and gestational weight gain represent important targets for all children. Healthy infant growth patterns carry special importance for children at increased risk for an autism spectrum disorder diagnosis.


2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Sorayya Kheirouri ◽  
Mohammad Alizadeh

Abstract Background Abnormal gestational weight gain (GWG) is a prenatal complication that may contribute to long-term behavioral and neurodevelopmental differences in offspring. This systematic review summarizes research on the association between maternal GWG and risk of autism spectrum disorder (ASD) in offspring. Methods Google and electronic databases, including PubMed, SCOPUS, Embase, Cochrane Library and Google Scholar, were searched for original human studies published in English through June 2020. Articles that examined the association between GWG and risk of ASD in offspring were included. Duplicate and irrelevant studies were removed; and data were obtained through critical analysis. Results Of 96 articles searched, eight studies were included in the final review. All studies (n = 7) investigating the association of maternal excessive GWG with risk of ASD in offspring indicated that high GWG was independently associated with an increased risk of ASD. Of five studies investigating the association of inadequate GWG with the risk of ASD, four indicated that low GWG was not associated with an increased risk of ASD. Of seven studies examining the association of maternal pre-pregnancy BMI or weight with the risk of ASD, five reported that maternal pre-pregnancy BMI or weight did not appear to be independently associated with risk of ASD. The GWG-ASD association is independent of maternal BMI and child’s intellectual disability, but offspring’s genetic susceptibility connection to the GWG-ASD association remains a topic of debate. Conclusions The findings suggest that maternal excessive GWG may be associated with increased risk of ASD in offspring. However, insufficient GWG does not appear to have such association.


Obesity ◽  
2020 ◽  
Vol 28 (11) ◽  
pp. 2224-2231
Author(s):  
Le Su ◽  
Cheng Chen ◽  
Liping Lu ◽  
Anny H. Xiang ◽  
Linda Dodds ◽  
...  

2019 ◽  
Vol 25 ◽  
pp. 268-269
Author(s):  
Bolanle Okunowo ◽  
Ifedayo Odeniyi ◽  
Oluwarotimi Olopade ◽  
Olufemi Fasanmade ◽  
Omololu Adegbola ◽  
...  

2009 ◽  
Vol 90 (5) ◽  
pp. 1288-1294 ◽  
Author(s):  
Ellen A Nohr ◽  
Michael Vaeth ◽  
Jennifer L Baker ◽  
Thorkild IA Sørensen ◽  
Jorn Olsen ◽  
...  

2013 ◽  
Vol 92 (7) ◽  
pp. 809-815 ◽  
Author(s):  
Nils-Halvdan Morken ◽  
Kari Klungsøyr ◽  
Per Magnus ◽  
Rolv Skjaerven

2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Susie Dzakpasu ◽  
John Fahey ◽  
Russell S Kirby ◽  
Suzanne C Tough ◽  
Beverley Chalmers ◽  
...  

PLoS ONE ◽  
2018 ◽  
Vol 13 (10) ◽  
pp. e0206035 ◽  
Author(s):  
Austrida Gondwe ◽  
Per Ashorn ◽  
Ulla Ashorn ◽  
Kathryn G. Dewey ◽  
Kenneth Maleta ◽  
...  

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