A Phase 2a Randomized, Parallel Group, Dose-Ranging Study of Molindone in Children with Attention-Deficit/Hyperactivity Disorder and Persistent, Serious Conduct Problems

2012 ◽  
Vol 22 (2) ◽  
pp. 102-111 ◽  
Author(s):  
Jennifer Dugan Stocks ◽  
Baldeo K. Taneja ◽  
Paolo Baroldi ◽  
Robert L. Findling
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Conduct Problems ◽  
Attention Deficit ◽  
Hyperactivity Disorder ◽  
Parallel Group ◽  
Dose Ranging

scholarly journals Conduct problems, gender and adult psychiatric outcome of children with attention-deficit hyperactivity disorder

2002 ◽  
Vol 181 (5) ◽  
pp. 416-421 ◽  
Author(s):  
Søren Dalsgaard ◽  
Preben Bo Mortensen ◽  
Morten Frydenberg ◽  
Per Hove Thomsen
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Conduct Problems ◽  
Attention Deficit ◽  
Psychiatric Admission ◽  
Case Register ◽  
Hyperactivity Disorder ◽  
Psychiatric Admissions ◽  
Girls With Adhd ◽  
Psychiatric Outcome

BackgroundAttention-deficit hyperactivity disorder (ADHD) is a common childhood condition, and is more prevalent in boys. The adult outcome of girls with ADHD has never been studied.AimsTo identify predictors for adult psychiatric outcome of children with ADHD, including gender and comorbidity.MethodChildren aged 4–15 years, referred for hyperactivity/inattention and treated with stimulants were included (n=208). The Psychiatric Case Register provided follow-up data on psychiatric admissions in adulthood until a mean age of 31 years.ResultsA total of 47 cases (22.6%) had a psychiatric admission in adulthood. Conduct problems in childhood were predictive (hazard ratio HR=2.3; 95% CI 1.22–4.33). Girls had a higher risk compared with boys (HR=2.4; 95% CI 1.1–5.6).ConclusionsGirls with ADHD had a higher risk of adult psychiatric admission than boys. Conduct problems were also associated with a higher risk. Girls with ADHD with conduct problems had a very high risk of a psychiatric admission in adulthood.

Are Psychotherapies for Young People Growing Stronger? Tracking Trends Over Time for Youth Anxiety, Depression, Attention-Deficit/Hyperactivity Disorder, and Conduct Problems

2018 ◽  
Vol 14 (2) ◽  
pp. 216-237 ◽  
Author(s):  
John R. Weisz ◽  
Sofie Kuppens ◽  
Mei Yi Ng ◽  
Rachel A. Vaughn-Coaxum ◽  
Ana M. Ugueto ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Conduct Problems ◽  
Attention Deficit ◽  
Mental Health Problems ◽  
Temporal Trends ◽  
Treatment Needs ◽  
Multiple Study ◽  
Hyperactivity Disorder ◽  
Anxiety Depression ◽  
Over Time

With the development of empirically supported treatments over the decades, have youth psychotherapies grown stronger? To investigate, we examined changes over time in treatment effects for four frequently treated youth mental-health problems: anxiety, depression, attention-deficit hyperactivity disorder (ADHD), and conduct disorders. We used PubMed and PsycINFO to search for randomized controlled trials (RCTs) that were published between January 1960 and May 2017 involving youths between the ages of 4 and 18 years. We also searched reviews and meta-analyses of youth psychotherapy research, followed reference trails in the reports we identified, and obtained additional studies identified by therapy researchers whom we contacted. We identified 453 RCTs (31,933 participants) spanning 53 years (1963–2016). Effect sizes for the problem-relevant outcome measures were synthesized via multilevel meta-analysis. We tracked temporal trends for each problem domain and then examined multiple study characteristics that might moderate those trends. Mean effect size increased nonsignificantly for anxiety, decreased nonsignificantly for ADHD, and decreased significantly for depression and conduct problems. Moderator analyses involving multiple study subgroups showed only a few exceptions to these surprising patterns. The findings suggest that new approaches to treatment design and intervention science may be needed, especially for depression and conduct problems. We suggest intensifying the search for mechanisms of change, making treatments more transdiagnostic and personalizable, embedding treatments within youth ecosystems, adapting treatments to the social and technological changes that alter youth dysfunction and treatment needs, and resisting old habits that can make treatments unduly skeuomorphic.

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