scholarly journals A systematic review of resting state functional MRI connectivity changes and cognitive impairment in multiple sclerosis

2021 ◽  
Author(s):  
Danka Jandric ◽  
Anisha Doshi ◽  
Richelle Scott ◽  
David Paling ◽  
David Rog ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Systematic Review ◽  
Cognitive Impairment ◽  
Functional Mri ◽  
Resting State

scholarly journals A systematic review of resting state functional MRI connectivity changes and cognitive impairment in multiple sclerosis

2021 ◽  
Author(s):  
Danka Jandric ◽  
Anisha Doshi ◽  
Richelle Scott ◽  
David Paling ◽  
David Rog ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Systematic Review ◽  
Cognitive Impairment ◽  
Functional Mri ◽  
Resting State ◽  
Narrative Synthesis ◽  
Clear Link ◽  
Study Methodology ◽  
Definition Of ◽  
Substantial Heterogeneity

Cognitive impairment is common in multiple sclerosis (MS) and resting state functional MRI (rs-fMRI) functional connectivity (FC) is increasingly used to study its pathophysiology. However, results remain difficult to interpret, showing both high and low FC associated with cognitive impairment. We conducted a systematic review of rs-fMRI studies in MS to understand whether the direction of FC change relates to cognitive dysfunction, and how this may be influenced by the choice of methodology. Embase, Medline and PsycINFO were searched for studies assessing cognitive function and rs-fMRI FC in adults with MS. Fifty-seven studies were included in a narrative synthesis. Of these, 50 found an association between cognitive impairment and FC abnormalities. Worse cognition was linked to high FC in 18 studies, and to low FC in 17 studies. Nine studies found patterns of both high and low FC related to poor cognitive performance, in different regions or for different MR metrics. There was no clear link to increased FC during early stages of MS and reduced FC in later stages, as predicted by common models of MS pathology. Throughout, we found substantial heterogeneity in study methodology, and carefully consider how this may impact on the observed findings. These results indicate an urgent need for greater standardisation in the field, in the choice of MRI analysis and the definition of cognitive impairment. Through this we will be closer to using rsfMRI FC as a biomarker in clinical studies, and as a tool to understand mechanisms underpinning cognitive symptoms in MS.

Unraveling the substrates of cognitive impairment in multiple sclerosis: A multiparametric structural and functional MRI study

2021 ◽  
Author(s):  
Lorenzo Conti ◽  
Paolo Preziosa ◽  
Alessandro Meani ◽  
Elisabetta Pagani ◽  
Paola Valsasina ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Functional Mri ◽  
Mri Study

Detecting cognitive impairment in HIV-infected individuals using mutual connectivity analysis of resting state functional MRI

2020 ◽  
Vol 26 (2) ◽  
pp. 188-200
Author(s):  
Anas Z. Abidin ◽  
Adora M. DSouza ◽  
Giovanni Schifitto ◽  
Axel Wismüller
Keyword(s):  
Cognitive Impairment ◽  
Functional Mri ◽  
Resting State ◽  
Connectivity Analysis

scholarly journals Mechanisms of Network Changes in Cognitive Impairment in Multiple Sclerosis

Neurology ◽  
2021 ◽  
pp. 10.1212/WNL.0000000000012834
Author(s):  
Danka Jandric ◽  
Ilona Lipp ◽  
David Paling ◽  
David Rog ◽  
Gloria Castellazzi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cognitive Impairment ◽  
Functional Connectivity ◽  
Resting State ◽  
Structural Connectivity ◽  
Cognitively Impaired ◽  
Anatomical Connectivity ◽  
Cross Sectional

Background and Objectives:Cognitive impairment in multiple sclerosis (MS) is associated with functional connectivity abnormalities. While there have been calls to use functional connectivity measures as biomarkers there remains to be a full understanding of why they are affected in MS. In this cross-sectional study we tested the hypothesis that functional network regions may be susceptible to disease-related ‘wear-and-tear’ and that this can be observable on co-occuring abnormalities on other MR metrics. We tested whether functional connectivity abnormalities in cognitively impaired MS patients co-occur with either 1) overlapping, 2) local, or 3) distal changes in anatomical connectivity and cerebral blood flow abnormalities.Methods:Multimodal 3T MRI and assessment with the Brief Repeatable Battery of Neuropsychological tests was performed in 102 relapsing-remitting MS patients and 27 healthy controls. MS patients were classified as cognitively impaired if they scored ≥1.5 standard deviations below the control mean on ≥2 tests (n=55), or else cognitively preserved (n=47). Functional connectivity was assessed with Independent Component Analysis and dual regression of resting-state fMRI images. Cerebral blood flow maps were estimated and anatomical connectivity was assessed with anatomical connectivity mapping and fractional anisotropy of diffusion-weighted MRI. Changes in cerebral blood flow and anatomical connectivity were assessed within resting state networks that showed functional connectivity abnormalities in cognitively impaired MS patients.Results:Functional connectivity was significantly decreased in the anterior and posterior default mode networks and significantly increased in the right and left frontoparietal networks in cognitively impaired relative to cognitively preserved MS patients (TFCE-corrected at p≤0.05, two-sided). Networks showing functional abnormalities showed altered cerebral blood flow and anatomical connectivity locally and distally but not in overlapping locations.Discussion:We provide the first evidence that FC abnormalities are accompanied with local cerebral blood flow and structural connectivity abnormalities but also demonstrate that these effects do not occur in exactly the same location. Our findings suggest a possibly shared pathological mechanism for altered functional connectivity in brain networks in MS.

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