Using CForest to Analyze Diffusion Tensor Imaging Data: A Study of White Matter Integrity in Healthy Aging

2016 ◽  
Vol 6 (10) ◽  
pp. 747-758 ◽  
Author(s):  
Sean R. McWhinney ◽  
Antoine Tremblay ◽  
Thérèse M. Chevalier ◽  
Vanessa K. Lim ◽  
Aaron J. Newman
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Healthy Aging ◽  
Diffusion Tensor ◽  
White Matter Integrity ◽  
Imaging Data ◽  
Diffusion Tensor Imaging Data

scholarly journals P.034 Eye movement assessment and diffusion tensor imaging in patients with post concussion syndrome

2016 ◽  
Vol 43 (S2) ◽  
pp. S29-S30
Author(s):  
F Taghdiri ◽  
SL Irwin ◽  
N Multani ◽  
M Eizenman ◽  
A Tarazi ◽  
...  
Keyword(s):  
Executive Function ◽  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Eye Tracking ◽  
Diffusion Tensor ◽  
White Matter Integrity ◽  
Matching Task ◽  
Imaging Data ◽  
Post Concussion Syndrome ◽  
Number Of Visits

Background: Post concussion syndrome (PCS) can affect up to 30% of patients with concussion. Biomarkers of this condition would be beneficial for diagnosis and management. We hypothesized that eye tracking parameters would correlate with microstructural changes of white matter integrity, as measured by diffusion tensor imaging (DTI), in patients with PCS. Methods: Sixty patients with PCS and at least 2 concussions participated in our prospective study. Attention and executive function were tested using Visual Attention Scanning Technology (VAST). In a matching task, the normalized number of visits to master image before making the first selection is used as a surrogate of working memory. We related performance on VAST to white matter integrity using Tract-Based Spatial Statistics of diffusion tensor imaging data. Results: 60 participants (mean age 34.3 years, SD 13.8) had a mean of 4 concussions. There were negative correlations between fractional anisotropy (FA) of the genu, body, and splenium of the corpus callosum and normalized number of visits to master image before first selection (r=-0.432, p=0.001; r=-0.504, p<0.001; and r=-0.388, p=0.002; respectively). A negative correlation was also seen between right cingulum FA and the global processing index (r=-0.349, p=0.006). Conclusions: Impaired performance on eye tracking measures of attention and executive function may reflect alterations in white matter tracts.

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