scholarly journals Whole brain white matter histogram analysis of diffusion tensor imaging data detects microstructural damage in mild cognitive impairment and alzheimer's disease patients

2018 ◽  
Vol 48 (3) ◽  
pp. 767-779 ◽  
Author(s):  
Giovanni Giulietti ◽  
Mario Torso ◽  
Laura Serra ◽  
Barbara Spanò ◽  
Camillo Marra ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Diffusion Tensor Imaging ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
Diffusion Tensor ◽  
Histogram Analysis ◽  
Imaging Data ◽  
Microstructural Damage ◽  
Brain White Matter ◽  
Diffusion Tensor Imaging Data

Two and Three-dimensional Analyses of Brain White Matter Architecture Using Diffusion Imaging

CNS Spectrums ◽  
2002 ◽  
Vol 7 (7) ◽  
pp. 529-534 ◽  
Author(s):  
Susumu Mori
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Magnetic Resonance ◽  
Fiber Orientation ◽  
Diffusion Tensor ◽  
Three Dimensional ◽  
Imaging Data ◽  
Brain White Matter ◽  
Orientation Information ◽  
Diffusion Tensor Imaging Data

ABSTRACTThe raw diffusion tensor imaging data obtained after tensor calculations contain six tensor elements in each pixel. This unique data structure poses difficulties in visualizing and analyzing diffusion tensor imaging data. One of the most commonly used visualization techniques is the use of color-coded maps. This presents fiber orientation information as a mixture of three principal colors. These maps can reveal white matter substructures that may not be visible in conventional magnetic resonance imaging. By extending the fiber-orientation information into three-dimensional space, three-dimensional trajectories of white matter tracts can then be estimated. Once locations and trajectories of tracts of interest are identified, this technique allows for the utilization of tract-specific magnetic resonance analyses and/or macroscopic characterization of white matter anatomy. As an example, anatomical deformation of the white matter resultant of brain tumor is demonstrated. The potentials and limitations of the three-dimensional tract reconstruction techniques are also highlighted.

Olfactory Function and Diffusion Tensor Imaging as Markers of Mild Cognitive Impairment in Early Stages of Parkinson's Disease

2021 ◽  
pp. 155005942110582
Author(s):  
Sophie A. Stewart ◽  
Laura Pimer ◽  
John D. Fisk ◽  
Benjamin Rusak ◽  
Ron A. Leslie ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Diffusion Tensor Imaging ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
Neurodegenerative Disorder ◽  
Diffusion Tensor ◽  
Early Stage ◽  
White Matter Integrity

Parkinson's disease (PD) is a neurodegenerative disorder that is typified by motor signs and symptoms but can also lead to significant cognitive impairment and dementia Parkinson's Disease Dementia (PDD). While dementia is considered a nonmotor feature of PD that typically occurs later, individuals with PD may experience mild cognitive impairment (PD-MCI) earlier in the disease course. Olfactory deficit (OD) is considered another nonmotor symptom of PD and often presents even before the motor signs and diagnosis of PD. We examined potential links among cognitive impairment, olfactory functioning, and white matter integrity of olfactory brain regions in persons with early-stage PD. Cognitive tests were used to established groups with PD-MCI and with normal cognition (PD-NC). Olfactory functioning was examined using the University of Pennsylvania Smell Identification Test (UPSIT) while the white matter integrity of the anterior olfactory structures (AOS) was examined using magnetic resonance imaging (MRI) diffusion tensor imaging (DTI) analysis. Those with PD-MCI demonstrated poorer olfactory functioning and abnormalities based on all DTI parameters in the AOS, relative to PD-NC individuals. OD and microstructural changes in the AOS of individuals with PD may serve as additional biological markers of PD-MCI.

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