The Default Mode Network in Healthy Individuals: A Systematic Review and Meta-Analysis

2017 ◽  
Vol 7 (1) ◽  
pp. 25-33 ◽  
Author(s):  
Lauren E. Mak ◽  
Luciano Minuzzi ◽  
Glenda MacQueen ◽  
Geoffrey Hall ◽  
Sidney H. Kennedy ◽  
...  
Keyword(s):  
Systematic Review ◽  
Default Mode Network ◽  
Meta Analysis ◽  
Healthy Individuals ◽  
Default Mode

scholarly journals Resting State Abnormalities of the Default Mode Network in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 70 (1) ◽  
pp. 107-120 ◽  
Author(s):  
Lisa T. Eyler ◽  
Jeremy A. Elman ◽  
Sean N. Hatton ◽  
Sarah Gough ◽  
Anna K. Mischel ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Default Mode Network ◽  
Resting State ◽  
Meta Analysis ◽  
Default Mode

Voxel-wise functional connectivity of the default mode network in epilepsies: a systematic review and meta-analysis

2021 ◽  
Vol 19 ◽  
Author(s):  
Sisi Jiang ◽  
Hechun Li ◽  
Linli Liu ◽  
Dezhong Yao ◽  
Cheng Luo
Keyword(s):  
Systematic Review ◽  
Functional Connectivity ◽  
Temporal Lobe ◽  
Default Mode Network ◽  
Focal Epilepsy ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Potential Candidate ◽  
Default Mode

Background: Default mode network (DMN) is recognized to be involved in generation and propagation of epileptic activities in various epilepsies. Converging evidence has suggested disturbed functional connectivity (FC) in epilepsies, which was inferred to be related to underlying pathological mechanisms. However, abnormal changes of FC in DMN revealed by different studies are controversial, which obscures the role of DMN in distinct epilepsies. Objective: The present work aims to investigate the voxel-wise FC in DMN across epilepsies. Methods: A systematic review was conducted on 22 published articles before October 2020 indexed in PubMed and Web of Science. A meta-analysis with a random-effect model was performed using the effect-size signed differential mapping approach. Subgroup analyses were performed in three groups: idiopathic generalized epilepsy (IGE), mixed temporal lobe epilepsy (TLE), and mixed focal epilepsy (FE) with different foci. Results: The meta-analysis suggested common decreased FC in mesial prefrontal cortices across different epilepsies. Additional decreased FC in posterior DMN was observed in IGE. The TLE showed decreased FC in temporal lobe regions and increased FC in dorsal posterior cingulate cortex. Interestingly, an opposite finding in ventral and dorsal middle frontal gyrus was observed in TLE. The FE demonstrated increased FC in cuneus. Conclusion: The current findings revealed both common and specific alterations of FC in DMN across different epilepsies, highlighting the contribution of these dysfunctions to epileptic activities and cognitive behaviors in patients. Furthermore, the current study provided powerful evidence to support DMN as a potential candidate for effective intervention in epilepsy.

scholarly journals Rumination and the default mode network: Meta-analysis of brain imaging studies and implications for depression

NeuroImage ◽  
2020 ◽  
Vol 206 ◽  
pp. 116287 ◽  
Author(s):  
Hui-Xia Zhou ◽  
Xiao Chen ◽  
Yang-Qian Shen ◽  
Le Li ◽  
Ning-Xuan Chen ◽  
...  
Keyword(s):  
Brain Imaging ◽  
Default Mode Network ◽  
Meta Analysis ◽  
Imaging Studies ◽  
Default Mode

scholarly journals Transdiagnostic and disease-specific abnormalities in the default-mode network hubs in psychiatric disorders: A meta-analysis of resting-state functional imaging studies

2020 ◽  
Vol 63 (1) ◽  
Author(s):  
Gaelle E. Doucet ◽  
Delfina Janiri ◽  
Rebecca Howard ◽  
Madeline O’Brien ◽  
Jessica R. Andrews-Hanna ◽  
...  
Keyword(s):  
Anxiety Disorders ◽  
Psychiatric Disorders ◽  
Default Mode Network ◽  
Resting State ◽  
Meta Analysis ◽  
Functional Integration ◽  
Likelihood Estimation ◽  
Default Mode ◽  
Mood And Anxiety Disorders ◽  
Disease Specific

Abstract Background. The default mode network (DMN) dysfunction has emerged as a consistent biological correlate of multiple psychiatric disorders. Specifically, there is evidence of alterations in DMN cohesiveness in schizophrenia, mood and anxiety disorders. The aim of this study was to synthesize at a fine spatial resolution the intra-network functional connectivity of the DMN in adults diagnosed with schizophrenia, mood and anxiety disorders, capitalizing on powerful meta-analytic tools provided by activation likelihood estimation. Methods. Results from 70 whole-brain resting-state functional magnetic resonance imaging articles published during the last 15 years were included comprising observations from 2,789 patients and 3,002 healthy controls. Results. Specific regional changes in DMN cohesiveness located in the anteromedial and posteromedial cortex emerged as shared and trans-diagnostic brain phenotypes. Disease-specific dysconnectivity was also identified. Unmedicated patients showed more DMN functional alterations, highlighting the importance of interventions targeting the functional integration of the DMN. Conclusion. This study highlights functional alteration in the major hubs of the DMN, suggesting common abnormalities in self-referential mental activity across psychiatric disorders.

Systematic review and meta-analysis investigating moderators of long-term effects of exercise on cognition in healthy individuals

2020 ◽  
Vol 4 (6) ◽  
pp. 603-612 ◽  
Author(s):  
Sebastian Ludyga ◽  
Markus Gerber ◽  
Uwe Pühse ◽  
Vera N. Looser ◽  
Keita Kamijo
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Healthy Individuals ◽  
Long Term Effects
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