Functional Connectivity Within the Default Mode Network Is Associated With Saccadic Accuracy in Parkinson's Disease: A Resting-State fMRI and Videooculographic Study

2013 ◽  
Vol 3 (3) ◽  
pp. 265-272 ◽  
Author(s):  
Martin Gorges ◽  
Hans-Peter Müller ◽  
Dorothée Lulé ◽  
Albert C. Ludolph ◽  
Elmar H. Pinkhardt ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Functional Connectivity ◽  
Default Mode Network ◽  
Resting State ◽  
Resting State Fmri ◽  
Default Mode

scholarly journals Altered functional connectivity in default mode network in absence epilepsy: A resting-state fMRI study

2011 ◽  
Vol 32 (3) ◽  
pp. 438-449 ◽  
Author(s):  
Cheng Luo ◽  
Qifu Li ◽  
Yongxiu Lai ◽  
Yang Xia ◽  
Yun Qin ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Default Mode Network ◽  
Resting State ◽  
Resting State Fmri ◽  
Absence Epilepsy ◽  
Default Mode ◽  
Fmri Study

scholarly journals Reduced Default Mode Network Functional Connectivity in Patients with Recurrent Major Depressive Disorder

2018 ◽  
Author(s):  
Chao-Gan Yan ◽  
Xiao Chen ◽  
Le Li ◽  
Francisco Xavier Castellanos ◽  
Tong-Jian Bai ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Functional Connectivity ◽  
Depressive Disorder ◽  
Default Mode Network ◽  
Resting State ◽  
Resting State Fmri ◽  
Research Groups ◽  
Major Depressive ◽  
Default Mode ◽  
Normal Controls

ABSTRACTMajor Depressive Disorder (MDD) is common and disabling, but its neuropathophysiology remains unclear. Most studies of functional brain networks in MDD have had limited statistical power and data analysis approaches have varied widely. The REST-meta-MDD Project of resting-state fMRI (R-fMRI) addresses these issues. Twenty-five research groups in China established the REST-meta-MDD Consortium by contributing R-fMRI data from 1,300 patients with MDD and 1,128 normal controls (NCs). Data were preprocessed locally with a standardized protocol prior to aggregated group analyses. We focused on functional connectivity (FC) within the default mode network (DMN), frequently reported to be increased in MDD. Instead, we found decreased DMN FC when we compared 848 patients with MDD to 794 NCs from 17 sites after data exclusion. We found FC reduction only in recurrent MDD, not in first-episode drug-naïve MDD. Decreased DMN FC was associated with medication usage but not with MDD duration. DMN FC was also positively related to symptom severity but only in recurrent MDD. Exploratory analyses also revealed alterations in FC of visual, sensory-motor and dorsal attention networks in MDD. We confirmed the key role of DMN in MDD but found reduced rather than increased FC within the DMN. Future studies should test whether decreased DMN FC mediates response to treatment. Finally, all resting-state fMRI indices of data contributed by the REST-meta-MDD consortium are being shared publicly via the R-fMRI Maps Project.SIGNIFICANCE STATEMENTFunctional connectivity within the default mode network in major depressive disorder patients has been frequently reported abnormal but with contradicting directions in previous small sample size studies. In creating the REST-meta-MDD consortium containing neuroimaging data of 1,300 depressed patients and 1,128 normal controls from 25 research groups in China, we found decreased default mode network functional connectivity in depressed patients, driven by patients with recurrent depression, and associated with current medication treatment but not with disease duration. These findings suggest that default mode network functional connectivity remains a prime target for understanding the pathophysiology of depression, with particular relevance to revealing mechanisms of effective treatments.

scholarly journals Altered functional connectivity of the default mode network in diffuse gliomas measured with pseudo-resting state fMRI

2013 ◽  
Vol 116 (2) ◽  
pp. 373-379 ◽  
Author(s):  
Robert J. Harris ◽  
Susan Y. Bookheimer ◽  
Timothy F. Cloughesy ◽  
Hyun J. Kim ◽  
Whitney B. Pope ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Default Mode Network ◽  
Resting State ◽  
Resting State Fmri ◽  
Default Mode ◽  
Diffuse Gliomas

Abstract 19: Default Mode Network Alterations in Cerebral Amyloid Angiopathy: A Resting State FMRI Study

Stroke ◽  
2020 ◽  
Vol 51 (Suppl_1) ◽  
Author(s):  
Mitchell J Horn ◽  
Elif Gokcal ◽  
Aina Frau-Pascual ◽  
Kristin M Schwab ◽  
Anand Viswanathan ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Cerebral Amyloid Angiopathy ◽  
Default Mode Network ◽  
Resting State ◽  
Resting State Fmri ◽  
Amyloid Angiopathy ◽  
Healthy Controls ◽  
Default Mode ◽  
Posterior Cingulate ◽  
Cerebral Amyloid

Introduction: Cerebral amyloid angiopathy (CAA) is an established cause of intracerebral hemorrhage and vascular dysfunction leading to ischemia. Functional connectivity analysis using MRI is becoming an important tool to analyze the brain activity during resting state, the default mode network (DMN) representing the prototypical set of connections. As CAA pathology has a posterior predominance, we sought to characterize the functional connectivity of the posterior DMN at resting state in patients with CAA. Methods: Patients with probable CAA diagnosed using Boston Criteria and healthy controls (HC) were prospectively enrolled and received high resolution 3T MRI scans including dedicated resting-state fMRI sequences. Functional seed-to-seed analyses were done using the default processing pipeline in the CONN Toolbox. Correlation maps between the established DMN and specific regions of the posterior DMN, the precuneus and posterior cingulate, were averaged within groups and compared in an ANCOVA model. Results: Study participants consisted of 60 patients with probable CAA and 20 healthy controls [aged 69 ± 7.5 vs 72.3 ± 8 years, P = 0.108]. Seed-to-seed analysis revealed a significantly lower strength of DMN connectivity in CAA when compared to controls in the precuneus [ P = 0.009] and posterior cingulate [ P = 0.003] adjusted for age and sex (Fig 1). Conclusion: Patients with CAA exhibited significant loss of connectivity in the posterior regions of the DMN when compared to controls. The precuneus and posterior cingulate are core regions of the DMN with reportedly high metabolic rates at rest. Disruption of these posterior DMN regions might occur due to vascular amyloid pathology that shows a predominantly posterior distribution.

scholarly journals The default mode network and cognition in Parkinson's disease: A multimodal resting‐state network approach

2021 ◽  
Author(s):  
Marina C. Ruppert ◽  
Andrea Greuel ◽  
Julia Freigang ◽  
Masoud Tahmasian ◽  
Franziska Maier ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Default Mode Network ◽  
Resting State ◽  
Network Approach ◽  
Default Mode ◽  
Resting State Network
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