scholarly journals The default mode network and cognition in Parkinson's disease: A multimodal resting‐state network approach

2021 ◽  
Author(s):  
Marina C. Ruppert ◽  
Andrea Greuel ◽  
Julia Freigang ◽  
Masoud Tahmasian ◽  
Franziska Maier ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Default Mode Network ◽  
Resting State ◽  
Network Approach ◽  
Default Mode ◽  
Resting State Network

scholarly journals Cognitive impairment and resting-state network connectivity in Parkinson's disease

2014 ◽  
Vol 36 (1) ◽  
pp. 199-212 ◽  
Author(s):  
Hugo-Cesar Baggio ◽  
Bàrbara Segura ◽  
Roser Sala-Llonch ◽  
Maria-José Marti ◽  
Francesc Valldeoriola ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Resting State ◽  
Network Connectivity ◽  
Resting State Network

Dopaminergic modulation of the default mode network in Parkinson's disease

2010 ◽  
Vol 20 (11) ◽  
pp. 784-792 ◽  
Author(s):  
Pauline Delaveau ◽  
Pilar Salgado-Pineda ◽  
Philippe Fossati ◽  
Tatiana Witjas ◽  
Jean-Philippe Azulay ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Default Mode Network ◽  
Default Mode ◽  
Dopaminergic Modulation

scholarly journals Effects of dopamine agonist treatment on resting-state network connectivity in Parkinson’s disease

2020 ◽  
Author(s):  
David M. Cole ◽  
Bahram Mohammadi ◽  
Maria Milenkova ◽  
Katja Kollewe ◽  
Christoph Schrader ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Decision Making ◽  
Parkinson's Disease ◽  
Basal Ganglia ◽  
Dopamine Agonist ◽  
Resting State ◽  
Large Scale ◽  
Network Connectivity ◽  
Resting State Network ◽  
Large Scale Networks

ABSTRACTDopamine agonist (DA) medications commonly used to treat, or ‘normalise’, motor symptoms of Parkinson’s disease (PD) may lead to cognitive-neuropsychiatric side effects, such as increased impulsivity in decision-making. Subject-dependent variation in the neural response to dopamine modulation within cortico-basal ganglia circuitry is thought to play a key role in these latter, non-motor DA effects. This neuroimaging study combined resting-state functional magnetic resonance imaging (fMRI) with DA modification in patients with idiopathic PD, investigating whether brain ‘resting-state network’ (RSN) functional connectivity metrics identify disease-relevant effects of dopamine on systems-level neural processing. By comparing patients both ‘On’ and ‘Off’ their DA medications with age-matched, un-medicated healthy control subjects (HCs), we identified multiple non-normalising DA effects on frontal and basal ganglia RSN cortico-subcortical connectivity patterns in PD. Only a single isolated, potentially ‘normalising’, DA effect on RSN connectivity in sensori-motor systems was observed, within cerebro-cerebellar neurocircuitry. Impulsivity in reward-based decision-making was positively correlated with ventral striatal connectivity within basal ganglia circuitry in HCs, but not in PD patients. Overall, we provide brain systems-level evidence for anomalous DA effects in PD on large-scale networks supporting cognition and motivated behaviour. Moreover, findings suggest that dysfunctional striatal and basal ganglia signalling patterns in PD are compensated for by increased recruitment of other cortico-subcortical and cerebro-cerebellar systems.

Primary disruption of the default mode network subsystems in drug-naïve Parkinson’s disease with mild cognitive impairments

2020 ◽  
Vol 62 (6) ◽  
pp. 685-692 ◽  
Author(s):  
Yanbing Hou ◽  
Xiaoqin Yuan ◽  
Qianqian Wei ◽  
Ruwei Ou ◽  
Jing Yang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Default Mode Network ◽  
Cognitive Impairments ◽  
Default Mode ◽  
Drug Naïve

Distinct manifestation of cognitive deficits associate with different resting-state network disruptions in non-demented patients with Parkinson’s disease

2018 ◽  
Vol 265 (3) ◽  
pp. 688-700 ◽  
Author(s):  
Kazuya Kawabata ◽  
Hirohisa Watanabe ◽  
Kazuhiro Hara ◽  
Epifanio Bagarinao ◽  
Noritaka Yoneyama ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Deficits ◽  
Resting State ◽  
Resting State Network ◽  
Network Disruptions
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