Cryopreservation of Porcine Aortic Heart Valve Leaflet-Derived Myofibroblasts

2010 ◽  
Vol 8 (4) ◽  
pp. 211-217 ◽  
Author(s):  
L.H. Campbell ◽  
K.G.M. Brockbank
Keyword(s):  
Heart Valve ◽  
Valve Leaflet ◽  
Aortic Heart Valve

scholarly journals On the biomechanical role of glycosaminoglycans in the aortic heart valve leaflet

2013 ◽  
Vol 9 (1) ◽  
pp. 4653-4660 ◽  
Author(s):  
Chad E. Eckert ◽  
Rong Fan ◽  
Brandon Mikulis ◽  
Mathew Barron ◽  
Christopher A. Carruthers ◽  
...  
Keyword(s):  
Heart Valve ◽  
Valve Leaflet ◽  
Aortic Heart Valve

FEA of displacements and stresses of aortic heart valve leaflets during the opening phase

2019 ◽  
Vol 1-2 (92) ◽  
pp. 29-35
Author(s):  
O. Bialas ◽  
J. Żmudzki
Keyword(s):  
Aortic Valve ◽  
Heart Valve ◽  
Poisson Ratio ◽  
Elastic Behaviour ◽  
Valve Leaflet ◽  
Element Analysis ◽  
Linear Elastic ◽  
Material Thickness ◽  
Aortic Heart Valve ◽  
Opening Phase

Purpose: Modelling of biomechanical behaviour of heart valve materials aids improvement of biofunctional feature. The aim of the work was assessment of influence of material thickness of leaflets of artificial aortic valve on displacements and stresses during opening phase using finite element analysis (FEA). Design/methodology/approach: The model of aortic valve was developed on the basis of average anatomical valve shapes and dimensions. Nonlinear dynamic large displacements analysis with assumption of isotropic linear elastic material behaviour was used in simulation (Solidworks). The modulus of elasticity of 5.0 MPa was assumed and Poisson ratio set to 0.45. The rigidly supported leaflets was loaded by pressure increasing in the range 0-55 mmHg in time 0.1 s. Leaflets with material thickness 0.13 and 0.15 and 0.17 mm were analysed. The thickness was simulated with shell finite elements. Findings: The highest stresses were observed in the areas of fixation of the leaflets near the scaffold and were lower than dangerous value of fatigue of polyurethanes. Increasing the thickness of valve leaflet material in the range of 40 micrometres resulted in reduction of the valve outlet by almost 10 percent. Research limitations/implications: The FEA was limited to the isotropic linear-elastic behaviour of the material albeit can be used to assess leaflet deformation during dynamic load. Practical implications: Leaflets design may be start from efficient FEA which helps estimation of material impact on stress and fold formation which can affect local blood flow. Originality/value: Aortic heart valve leaflet material can be initially tested in dynamic conditions during opening phase with using FEA.

scholarly journals Time-dependent biaxial mechanical behavior of the aortic heart valve leaflet

2007 ◽  
Vol 40 (14) ◽  
pp. 3169-3177 ◽  
Author(s):  
John A. Stella ◽  
Jun Liao ◽  
Michael S. Sacks
Keyword(s):  
Mechanical Behavior ◽  
Heart Valve ◽  
Time Dependent ◽  
Valve Leaflet ◽  
Aortic Heart Valve

scholarly journals The concept of automated functional design of heart valve prostheses

2021 ◽  
Vol 10 (2) ◽  
pp. 63-67
Author(s):  
P. S. Onishchenko ◽  
K. Yu. Klyshnikov ◽  
M. A. Rezvova ◽  
E. A. Ovcharenko
Keyword(s):  
Numerical Modeling ◽  
Heart Valve ◽  
Von Mises Stress ◽  
Radius Of Curvature ◽  
Valve Leaflet ◽  
Functional Design ◽  
Aortic Heart Valve ◽  
Valve Prostheses ◽  
Von Mises ◽  
Matlab Programming

Aim. To develop an algorithm for the automated functional design of the heart valve leaflet apparatus.Methods. The geometry of the aortic valve leaflet was designed in the Matlab programming environment (MathWorks, Massachusetts, USA). Numerical modeling of the opening process was performed using Abaqus/CAE (Dassault Systemes, France).Results. We developed an algorithm, with the help of which a set of models of the leaflet apparatus was designed. 8 models were subjected to numerical modeling of the stress-strain state. The locking pressure simulation has shown that the smallest von Mises stress value was recorded for a sample with a larger surface area of the leaflet belly and it equals 0.422 MPa. The results obtained show that the value of the radius of curvature significantly affects the behavior of the entire valve, which leads to the conclusion that it is necessary to carefully select the design of the valve apparatus for its correct functioning.Conclusion. The study provides the primary confirmation that the concept of the algorithm is efficient for the automated functional design of the aortic heart valve leaflet apparatus. 

scholarly journals Interlayer micromechanics of the aortic heart valve leaflet

2013 ◽  
Vol 13 (4) ◽  
pp. 813-826 ◽  
Author(s):  
Rachel M. Buchanan ◽  
Michael S. Sacks
Keyword(s):  
Heart Valve ◽  
Valve Leaflet ◽  
Aortic Heart Valve

Transcatheter aortic heart valve (THV) implantation of Edwards Sapien™ bioprothesis – using a mobile x-ray-system or a hybrid-OR?

2010 ◽  
Vol 58 (S 01) ◽  
Author(s):  
H Schröfel ◽  
G Schymik ◽  
A Würth ◽  
V Elsner ◽  
BD Gonska ◽  
...  
Keyword(s):  
Heart Valve ◽  
X Ray ◽  
Aortic Heart Valve ◽  
Edwards Sapien

scholarly journals Mechanical and Degradation Properties of Hybrid Scaffolds for Tissue Engineered Heart Valve (TEHV)

2021 ◽  
Vol 12 (1) ◽  
pp. 20
Author(s):  
Rabia Nazir ◽  
Arne Bruyneel ◽  
Carolyn Carr ◽  
Jan Czernuszka
Keyword(s):  
Heart Valve ◽  
Crosslinking Density ◽  
Biomechanical Properties ◽  
Collagen Type I ◽  
Type I ◽  
Aortic Heart Valve ◽  
Tissue Engineered Heart Valve ◽  
Human Aortic Valve ◽  
Degradation Properties ◽  
Hybrid Scaffolds

In addition to biocompatibility, an ideal scaffold for the regeneration of valvular tissue should also replicate the natural heart valve extracellular matrix (ECM) in terms of biomechanical properties and structural stability. In our previous paper, we demonstrated the development of collagen type I and hyaluronic acid (HA)-based scaffolds with interlaced microstructure. Such hybrid scaffolds were found to be compatible with cardiosphere-derived cells (CDCs) to potentially regenerate the diseased aortic heart valve. This paper focused on the quantification of the effect of crosslinking density on the mechanical properties under dry and wet conditions as well as degradation resistance. Elastic moduli increased with increasing crosslinking densities, in the dry and wet state, for parent networks, whereas those of interlaced scaffolds were higher than either network alone. Compressive and storage moduli ranged from 35 ± 5 to 95 ± 5 kPa and 16 ± 2 kPa to 113 ± 6 kPa, respectively, in the dry state. Storage moduli, in the dry state, matched and exceeded those of human aortic valve leaflets (HAVL). Similarly, degradation resistance increased with increasing the crosslinking densities for collagen-only and HA-only scaffolds. Interlaced scaffolds showed partial degradation in the presence of either collagenase or hyaluronidase as compared to when exposed to both enzymes together. These results agree with our previous findings that interlaced scaffolds were composed of independent collagen and HA networks without crosslinking between them. Thus, collagen/HA interlaced scaffolds have the potential to fill in the niche for designing an ideal tissue engineered heart valve (TEHV).

The Influence of the Aortic Root Geometry on Flow Characteristics of a Prosthetic Heart Valve

2015 ◽  
Vol 137 (5) ◽  
Author(s):  
Oleksandr Barannyk ◽  
Peter Oshkai
Keyword(s):  
Aortic Valve ◽  
Heart Valve ◽  
Aortic Root ◽  
Reynolds Shear Stress ◽  
Prosthetic Heart Valve ◽  
Flow Characteristics ◽  
Aortic Pressure ◽  
Valve Prosthesis ◽  
Aortic Heart Valve ◽  
Valve Diseases

In this paper, performance of aortic heart valve prosthesis in different geometries of the aortic root is investigated experimentally. The objective of this investigation is to establish a set of parameters, which are associated with abnormal flow patterns due to the flow through a prosthetic heart valve implanted in the patients that had certain types of valve diseases prior to the valve replacement. Specific valve diseases were classified into two clinical categories and were correlated with the corresponding changes in aortic root geometry while keeping the aortic base diameter fixed. These categories correspond to aortic valve stenosis and aortic valve insufficiency. The control case that corresponds to the aortic root of a patient without valve disease was used as a reference. Experiments were performed at test conditions corresponding to 70 beats/min, 5.5 L/min target cardiac output, and a mean aortic pressure of 100 mmHg. By varying the aortic root geometry, while keeping the diameter of the orifice constant, it was possible to investigate corresponding changes in the levels of Reynolds shear stress and establish the possibility of platelet activation and, as a result of that, the formation of blood clots.

Sign in / Sign up

Export Citation Format

Share Document