Oxidative Stress and Cancer Development: Are Noncoding RNAs the Missing Links?

2020 ◽  
Vol 33 (17) ◽  
pp. 1209-1229 ◽  
Author(s):  
Leonard Clinton D'Souza ◽  
Shruti Mishra ◽  
Anirban Chakraborty ◽  
Anusmita Shekher ◽  
Anurag Sharma ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Noncoding Rnas ◽  
Cancer Development

scholarly journals Role of Pirin, an Oxidative Stress Sensor Protein, in Epithelial Carcinogenesis

Biology ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 116
Author(s):  
Francisco Perez-Dominguez ◽  
Diego Carrillo-Beltrán ◽  
Rancés Blanco ◽  
Juan P. Muñoz ◽  
Grettell León-Cruz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cancer Development ◽  
Biological Factors ◽  
Epithelial Cancers ◽  
Physical Chemical ◽  
Sensor Protein ◽  
Cupin Superfamily ◽  
Functionally Diverse ◽  
Light Chain Enhancer

Pirin is an oxidative stress (OS) sensor belonging to the functionally diverse cupin superfamily of proteins. Pirin is a suggested quercetinase and transcriptional activator of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway. Its biological role in cancer development remains a novel area of study. This review presents accumulating evidence on the contribution of Pirin in epithelial cancers, involved signaling pathways, and as a suggested therapeutic target. Finally, we propose a model in which Pirin is upregulated by physical, chemical or biological factors involved in OS and cancer development.

Noncoding RNAs in the Vascular System Response to Oxidative Stress

2019 ◽  
Vol 30 (7) ◽  
pp. 992-1010 ◽  
Author(s):  
Paola Fuschi ◽  
Biagina Maimone ◽  
Carlo Gaetano ◽  
Fabio Martelli
Keyword(s):  
Oxidative Stress ◽  
Vascular System ◽  
Noncoding Rnas ◽  
System Response

scholarly journals Oxidative stress and antioxidants in the trabecular meshwork

PeerJ ◽  
2019 ◽  
Vol 7 ◽  
pp. e8121 ◽  
Author(s):  
Mingxuan Wang ◽  
Yajuan Zheng
Keyword(s):  
Oxidative Stress ◽  
Trabecular Meshwork ◽  
Noncoding Rnas ◽  
Treatment Strategies ◽  
Stress Alleviation ◽  
New Targets ◽  
Age Dependent ◽  
Exogenous Compounds ◽  
Irreversible Blindness

Glaucoma is an age-dependent disease closely related to oxidative stress and is regarded as the second leading cause of irreversible blindness worldwide. In recent years, many studies have shown that morphological and functional abnormalities of the trabecular meshwork (TM) are closely related to glaucoma, especially with respect to oxidative stress. In this review, the mechanisms of oxidative stress in the TM and treatment strategies for this condition, including strategies involving antioxidants, noncoding RNAs and exogenous compounds, are discussed. Although many questions remain to be answered, the reviewed findings provide insights for further research on oxidative stress alleviation in glaucoma and suggest new targets for glaucoma prevention.

scholarly journals The role of exosomal lncRNAs in cancer biology and clinical management

2021 ◽  
Author(s):  
Wuwen Zhang ◽  
Qinshi Wang ◽  
Yi Yang ◽  
Siyuan Zhou ◽  
Ping Zhang ◽  
...  
Keyword(s):  
Clinical Management ◽  
Cancer Biology ◽  
Cell Communication ◽  
Noncoding Rnas ◽  
Vital Role ◽  
Cancer Development ◽  
Cancer Cell Proliferation ◽  
Diagnosis And Prognosis ◽  
Multiple Processes

AbstractExosomes play a vital role in cell–cell communication within the cancer microenvironment. Exosomal long noncoding RNAs (lncRNAs) are important regulators in cancer development and are involved in multiple processes, including cancer cell proliferation, angiogenesis, metastasis, drug resistance, and immunomodulation. Changes in the levels of exosomal lncRNAs often appear with the occurrence and development of cancer. Therefore, exosomal lncRNAs can be used as biomarkers for cancer diagnosis and prognosis. Exosomal lncRNAs can also indicate the treatment response of patients receiving chemotherapy. Moreover, exosomal lncRNAs are potential therapeutic targets for cancer treatment. In this review, we summarize the role of exosomal lncRNAs in cancer biology as well as in clinical management. A more comprehensive and in-depth understanding of the role of exosomal lncRNAs in cancer may help us better understand the mechanism of cancer development and clinically manage cancer patients.

scholarly journals Role of Pirin, an Oxidative Stress Sensor Protein, in Epithelial Carcinogenesis

2020 ◽  
Author(s):  
Francisco Perez-Dominguez ◽  
Diego Carrillo-Beltrán ◽  
Rancés Blanco ◽  
Juan P. Muñoz ◽  
Grettell León-Cruz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cancer Development ◽  
Biological Factors ◽  
Epithelial Cancers ◽  
Physical Chemical ◽  
Sensor Protein ◽  
Cupin Superfamily ◽  
Functionally Diverse ◽  
Light Chain Enhancer

Pirin is an oxidative stress (OS) sensor belonging to the functionally diverse cupin superfamily of proteins. Pirin is a suggested quercetinase and transcriptional activator of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway. Its biological role in cancer development remains as a novel area of study. This review shows accumulating evidence on the contribution of Pirin in epithelial cancers, signaling pathways involved, and as a suggested therapeutic target. Finally, we propose a model in which Pirin is upregulated by physical, chemical or biological factors involved in OS and cancer development.

scholarly journals Cytoglobin Deficiency Promotes Liver Cancer Development from Hepatosteatosis through Activation of the Oxidative Stress Pathway

2015 ◽  
Vol 185 (4) ◽  
pp. 1045-1060 ◽  
Author(s):  
Le Thi Thanh Thuy ◽  
Yoshinari Matsumoto ◽  
Tuong Thi Van Thuy ◽  
Hoang Hai ◽  
Maito Suoh ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Cancer ◽  
Cancer Development ◽  
Oxidative Stress Pathway ◽  
Stress Pathway

scholarly journals The role of heme oxygenase in metastatic melanoma tumorigenicity

2015 ◽  
Author(s):  
◽  
Kimberly J. Jasmer
Keyword(s):  
Oxidative Stress ◽  
Metastatic Melanoma ◽  
Heme Oxygenase ◽  
Focal Adhesion ◽  
Target Genes ◽  
Cancer Development ◽  
Heme Oxygenase Activity ◽  
Oxygenase Activity ◽  
Receptor Interactions

Reactive oxygen species (ROS) are highly reactive, tumorigenic molecules. In response to ROS accumulation, or oxidative stress, the transcription factor Nrf2 promotes expression by binding antioxidant response elements (AREs) found in the promoter of target genes. Traditionally, Nrf2 has been considered inhibitory of cancer by promoting the expression of phase II detoxifying enzymes, drug transporters, anti-apoptotic proteins, and proteasomes, which facilitate the removal of ROS and promote cell survival. Recently, however, overexpression of Nrf2-target genes has been implicated in promoting several cancer hallmarks and facilitating cancer development. Significant focus has been given to the role of Keap1/Nrf2 as a sensor for oxidative stress. Much less attention has been paid to the role of Bach1, a transcriptional repressor that competes with Nrf2 for ARE binding. The best-characterized Bach1 target is Heme Oxygenase-1 (HMOX1). While heme oxygenase inhibits cancer by preventing ROS-induced damage, mounting evidence suggests that HMOX1 overexpression at later stages in cancer development may promote cancer progression. Heme oxygenase catalyzes the degradation of heme and has two isozymes. HMOX1 is inducible by heme and oxidative stress while HMOX2 is constitutively expressed. Stage IV metastatic melanoma has a median survival of only 6 to 10 months. Unfortunately, current therapeutic approaches provide limited benefit in overall survival, highlighting the need for the identification of novel therapeutic targets. Activating mutations in B-Raf are found in approximately 70% of malignant melanomas. Using an anchorage-independent melanosphere assay, which is indicative of the tumorigenicity of melanoma cells, we found that activation of B-Raf, but not N-Ras, is a driver of melanosphere formation. We provide evidence that derepression of Bach1 by treatment with cobalt protoporphyrin IX (CoPP) is sufficient for melanosphere formation, and that melanosphere formation induced by either CoPP treatment or B-Raf activation is dependent on heme oxygenase activity. Global transcriptome analysis revealed enrichment for genes involved in focal adhesion and extracellular matrix (ECM)-receptor interactions following either B-Raf activation or treatment with CoPP. We propose a mechanism by which heme oxygenase promotes melanosphere formation, and by extension, enhanced tumorigenicity, by modulating expression of genes involved in focal adhesion and ECM-receptor interactions. Heme oxygenase activity may provide a novel therapeutic target for the treatment of metastatic melanoma.

scholarly journals Regulation Mechanism of Long Noncoding RNAs in Colon Cancer Development and Progression

2019 ◽  
Vol 60 (4) ◽  
pp. 319 ◽  
Author(s):  
Xiaohuan Tang ◽  
Xiaofang Qiao ◽  
Chao Chen ◽  
Yuanda Liu ◽  
Jiaming Zhu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas ◽  
Cancer Development ◽  
Regulation Mechanism
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