Aberrant Upregulation of Compensatory Redox Molecular Machines May Contribute to Sperm Dysfunction in Infertile Men with Unilateral Varicocele: A Proteomic Insight

2020 ◽  
Vol 32 (8) ◽  
pp. 504-521 ◽  
Author(s):  
Nirlipta Swain ◽  
Luna Samanta ◽  
Ashok Agarwal ◽  
Sugandh Kumar ◽  
Anshuman Dixit ◽  
...  
Keyword(s):  
Molecular Machines ◽  
Infertile Men ◽  
Sperm Dysfunction

IVF and male infertility

1992 ◽  
Vol 1 (2) ◽  
pp. 151-164 ◽  
Author(s):  
Susan M Avery
Keyword(s):  
Male Infertility ◽  
Semen Quality ◽  
Semen Analysis ◽  
World Health ◽  
Semen Parameters ◽  
Infertile Men ◽  
Health Organization ◽  
Sperm Dysfunction

Male infertility, while having a variety of causes, is generally discussed in terms of semen parameters. While the World Health Organization (WHO) have been able io set limits for semen parameters below which a male can be considered subfertile (20 million/ml; >50% motility; >50% morphologically normal forms), it is well documented thatin vivoconceptions have been achieved where semen quality falls well outside these limits, and that infertile men may have normal semen parameters. Macleod and Gold in comparing 1000 fertile men and 1000 infertile men, found that significantly more infertile men had sperm densities below 20 million/ml, but also that 60% of infertile men had sperm densities of 60 million or more. Jouannet and Feneaux have shown that the conception ratein vivoonly apparently falls significantly at sperm concentrations of less than five million/ml. Although the cause of subnormal semen analysis is unknown in the majority of cases, there is no reason to suppose that abnormal semen parameters on their own are the cause of infertility. Rather the problem may be caused by failure of sufficient numbers of sperm traversing the female tract and reaching the oocyte. Unfortunately, lack of defined diagnoses lead to a lack of direct treatment for subnormal semen parameters. The development ofin vitrofertilization (IVF) resulted in a method that could be used to circumvent the problem since it requires relatively low numbers of sperm and these are placed in the immediate vicinity of the oocyte. It should also be pointed out that normal semen parameters do not imply fertility, since these parameters cannot directly identify dysfunction. IVF offers the advantage that sperm-oocyte interractions can be observed, and in cases of fertilization failure, the point at which sperm dysfunction manifests itself may potentially be identified – if not the nature of the dysfunction. Techniques have now been developed that may overcome certain types of dysfunction, using both biochemical and mechanical means.

1356: The Reversibility of Hyperthermia Effects on Semen Quality in Infertile Men

2005 ◽  
Vol 173 (4S) ◽  
pp. 368-368
Author(s):  
Shai Shefi ◽  
Phiroz Tarapore ◽  
Paul J. Turek
Keyword(s):  
Semen Quality ◽  
Infertile Men

1574: The Incidence of Testicular Cancer in Infertile Men

2004 ◽  
Vol 171 (4S) ◽  
pp. 415-415
Author(s):  
Deborah M. Spaine ◽  
Renato Fraietta ◽  
Carolina Homsi ◽  
Agnaldo P. Cedenho ◽  
Miguel Srougi
Keyword(s):  
Testicular Cancer ◽  
Infertile Men

1386: Role of Seminal Growth Factors in Infertile Men with Varicocele

2004 ◽  
Vol 171 (4S) ◽  
pp. 365-365
Author(s):  
Tamer M. Said ◽  
Shyam Allamaneni ◽  
Kiran P. Nallella ◽  
Rakesh K. Sharma ◽  
Mohamed A. Bedaiwy ◽  
...  
Keyword(s):  
Growth Factors ◽  
Infertile Men

The correlation between the sociodemographic characteristics and some hormones with the infertility of women and men

10.32947/357 ◽  
2018 ◽  
Vol 18 (1) ◽  
pp. 1-10
Keyword(s):  
Soft Drink ◽  
Serum Prolactin ◽  
Age Group ◽  
Tea Consumption ◽  
Obese Women ◽  
Overweight Women ◽  
Infertile Women ◽  
Infertile Men ◽  
Overweight Group ◽  
Prolactin Hormone

Thirty three infertile women were divided into two groups according to their BMI (21 obese and 12 overweight) there age ranges between (16-41) years, with their husbands twenty one infertile men and twelve fertile men and their ages range between (23-46) years. In the present study we observed that several indicators affect the fertility such as BMI in infertile obese women which was 34.65 kg/m2. That is higher than that of overweight infertile women that recorded 24.87 kg/m2. obese housewives scored the highest percentage (85.71%) compared with the overweight group (25%), In addition the obese age group between 30-41 years scored (66.67%) compared with the overweight group whose members’ age 16-29.9 years scored 75%. However, drinking cola (soft drink) percentage in obese infertile women was (85.71%) and the tea consumption was higher in overweight group (66.67%). The hormones FSH and LH decrease in obese women but serum prolactin hormone increased twice about 29.27 ng/ml in comparison with overweight group. Testosterone hormone decreased in obese women but Leptin in obese women (19.52 μg/L) was higher than that of overweight women (11.03 μg/L). Infertile unemployed men got the highest percentage of 66.67%. Besides, the smoker infertile men were higher in percentage (80.95%) compared with fertile men 41.67%. The elevated LH, FSH and prolactin values are significantly high (p<0.01) (7.895 mlU/ml, 9.89 mlU/ml and 13.33 ng/ml) respectively, but the testosterone was significantly low (3.91 ng/dl) in comparison with fertile men(21.76ng/dl). Whileleptin significantly increased in infertile men more than the fertile ones. These changes in hormones have a great correlation with semen characteristics as the abnormalities in sperms increased to (64.52) and the percentage of rapid, progressive and non -progressive motility decreased, but the immotile motility was highly significant (65.71) in infertile men. As a result this indicates that the reason of infertility is shared between the wife and husband.

PATTERN OF 17-KETOSTEROID URINARY EXCRETION IN INFERTILE MEN

1963 ◽  
Vol 42 (1) ◽  
pp. 97-100
Author(s):  
Mirjam Furuhjelm ◽  
Birgit Johnson ◽  
C.-G. Lagergren
Keyword(s):  
Urinary Excretion ◽  
Sperm Cells ◽  
Infertile Men ◽  
Abnormal Cells

ABSTRACT The pattern of the 17-ketosteroid excretion determined according to Johnsen (1956) in a group of 33 sterile men was compared with that in another group of 14 men with proved fertility, and no difference was found. No correlation between 17-ketosteroid excretion and the concentration of sperm cells or the percentage of abnormal cells could be detected. The results are discussed.

Molecular Machines

2018 ◽  
Author(s):  
Giovanni Zocchi
Keyword(s):  
Molecular Machines

Molecular Typing of Toxoplasma Gondii Isolated from Infertile Men and Its Effect on the Reproduction

2018 ◽  
Vol 14 (1) ◽  
pp. 141-152
Author(s):  
Nazar Mohammed ◽  
◽  
Farhan Risan ◽  
Salwa Muhsin
Keyword(s):  
Toxoplasma Gondii ◽  
Molecular Typing ◽  
Infertile Men

Detection Y Chromosome Microdeletions Among Iraq Population in Infertile Patients with Azoospermia and Severe Oligospermia

2019 ◽  
Vol 9 (02) ◽  
Author(s):  
Samah A Hammood ◽  
Alaauldeen S M AL-Sallami ◽  
Saleh M Al-Khafaji
Keyword(s):  
Y Chromosome ◽  
Karyotype Analysis ◽  
Semen Analysis ◽  
Obstructive Azoospermia ◽  
Severe Oligozoospermia ◽  
Infertile Men ◽  
Y Chromosome Microdeletions ◽  
Detailed Evaluation ◽  
Health Organization ◽  
Infertile Patients

Objective: To detection of microdeletions of Y chromosome and study the frequency of microdeletions in infertile men with non-obstructive azoospermia or severe oligozoospermia(Middle Euphrates center)in Iraq population. Material and methods: 153 males were included in the study, the casesweredivided into groups according to the infertility etiology and semen analysis according to Word health organization, the frequencies and the characteristicsof Y chromosome microdeletions were investigated in groups. Multiplex PCR was applied to detect the microdeletions. Results:Y chromosome microdeletion was detected in 42 (40.7%) of 153 cases ,Microdeletions in azoospermia showed more frequently detected 28 (52.8%), followed by severe oligospermia 14 (28 %),Microdeletions in the AZFc region were the most common 12 (22.64%), followed by AZFb 11(20.75%) and AZFa 5(9.43%) in azoospermia compared to severe oligospermisAZFc 6 (12%) AZFb 4 (8 %) and AZFa 4 (8%). Conclusion: Y chromosome microdeletions were detected quite frequently in certain infertility subgroups. Therefore, detailed evaluation of an infertile man by physical examination, semen analysis, hormonal evaluationsand when required, karyotype analysis may predict the patients for whom Y chromosome microdeletionanalysis is necessary and also prevent cost increases. Recommendation: This study emphasizes that analysis of microdeletions should be carried out for all patients with idiopathic azoospermia and severe oligospermia who are candidates for intracytoplasmic sperm injection

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