scholarly journals Cystathionine γ-Lyase–Hydrogen Sulfide Induces Runt-Related Transcription Factor 2 Sulfhydration, Thereby Increasing Osteoblast Activity to Promote Bone Fracture Healing

2017 ◽  
Vol 27 (11) ◽  
pp. 742-753 ◽  
Author(s):  
Yang Zheng ◽  
Feng Liao ◽  
Xianjuan Lin ◽  
Fengjiao Zheng ◽  
Jinghui Fan ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Hydrogen Sulfide ◽  
Fracture Healing ◽  
Bone Fracture ◽  
Bone Fracture Healing ◽  
Osteoblast Activity ◽  
Related Transcription Factor

scholarly journals Sonic Hedgehog Regulates Bone Fracture Healing

2020 ◽  
Vol 21 (2) ◽  
pp. 677 ◽  
Author(s):  
Hiroaki Takebe ◽  
Nazmus Shalehin ◽  
Akihiro Hosoya ◽  
Tsuyoshi Shimo ◽  
Kazuharu Irie
Keyword(s):  
Fracture Healing ◽  
Sonic Hedgehog ◽  
Bone Fracture ◽  
Endochondral Ossification ◽  
Bone Matrix ◽  
Sprague Dawley ◽  
Bone Fracture Healing ◽  
Related Transcription Factor ◽  
The Right ◽  
Osteoblast Markers

Bone fracture healing involves the combination of intramembranous and endochondral ossification. It is known that Indian hedgehog (Ihh) promotes chondrogenesis during fracture healing. Meanwhile, Sonic hedgehog (Shh), which is involved in ontogeny, has been reported to be involved in fracture healing, but the details had not been clarified. In this study, we demonstrated that Shh participated in fracture healing. Six-week-old Sprague–Dawley rats and Gli-CreERT2; tdTomato mice were used in this study. The right rib bones of experimental animals were fractured. The localization of Shh and Gli1 during fracture healing was examined. The localization of Gli1 progeny cells and osterix (Osx)-positive cells was similar during fracture healing. Runt-related transcription factor 2 (Runx2) and Osx, both of which are osteoblast markers, were observed on the surface of the new bone matrix and chondrocytes on day seven after fracture. Shh and Gli1 were co-localized with Runx2 and Osx. These findings suggest that Shh is involved in intramembranous and endochondral ossification during fracture healing.

Ultrasonic Diagnosis for Bone Fracture Healing Process

2020 ◽  
Author(s):  
Satoshi Kimura ◽  
Keisuke Oe ◽  
Yohei Kumabe ◽  
Tomoaki Fukui ◽  
Takahiro Niikura ◽  
...  
Keyword(s):  
Fracture Healing ◽  
Bone Fracture ◽  
Healing Process ◽  
Ultrasonic Diagnosis ◽  
Bone Fracture Healing

scholarly journals Diminished Callus Size and Cartilage Synthesis in α1β1 Integrin-Deficient Mice during Bone Fracture Healing

2002 ◽  
Vol 160 (5) ◽  
pp. 1779-1785 ◽  
Author(s):  
Erika Ekholm ◽  
Kurt D. Hankenson ◽  
Hannele Uusitalo ◽  
Ari Hiltunen ◽  
Humphrey Gardner ◽  
...  
Keyword(s):  
Fracture Healing ◽  
Bone Fracture ◽  
Bone Fracture Healing ◽  
Callus Size ◽  
Deficient Mice ◽  
And Cartilage

scholarly journals Differentiation mechanisms of regeneration blastema cells during bone fracture healing

2018 ◽  
Vol 0 (2) ◽  
pp. 78-86
Author(s):  
Alexey Popsuishapka ◽  
Valeriy Litvishko ◽  
Nataliya Ashukina ◽  
Vitaliy Grigoryev ◽  
Olga Pidgaiska
Keyword(s):  
Fracture Healing ◽  
Bone Fracture ◽  
Bone Fracture Healing ◽  
Regeneration Blastema
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