Akkermansia Muciniphila Promotes Bone Fracture Healing by Enhancing Preosteoclast-Associated Type H Vessel Formation

2019 ◽  
Author(s):  
Jiang-Hua Liu ◽  
Tao Yue ◽  
Zhong-Wei Luo ◽  
Jia Cao ◽  
Zi-Qi Yan ◽  
...  
Keyword(s):  
Fracture Healing ◽  
Bone Fracture ◽  
Bone Fracture Healing ◽  
Vessel Formation ◽  
Akkermansia Muciniphila

scholarly journals Akkermansia muciniphila promotes type H vessel formation and bone fracture healing by reducing gut permeability and inflammation

2020 ◽  
Vol 13 (11) ◽  
pp. dmm043620 ◽  
Author(s):  
Jiang-Hua Liu ◽  
Tao Yue ◽  
Zhong-Wei Luo ◽  
Jia Cao ◽  
Zi-Qi Yan ◽  
...  
Keyword(s):  
Fracture Healing ◽  
Systemic Inflammation ◽  
Bone Healing ◽  
Bone Fracture ◽  
Early Stage ◽  
Gut Permeability ◽  
Bone Fracture Healing ◽  
Gut Barrier ◽  
Vessel Formation ◽  
Akkermansia Muciniphila

ABSTRACTImproving revascularization is one of the major measures in fracture treatment. Moderate local inflammation triggers angiogenesis, whereas systemic inflammation hampers angiogenesis. Previous studies showed that Akkermansia muciniphila, a gut probiotic, ameliorates systemic inflammation by tightening the intestinal barrier. In this study, fractured mice intragastrically administrated with A. muciniphila were found to display better fracture healing than mice treated with vehicle. Notably, more preosteclasts positive for platelet-derived growth factor-BB (PDGF-BB) were induced by A. muciniphila at 2 weeks post fracture, coinciding with increased formation of type H vessels, a specific vessel subtype that couples angiogenesis and osteogenesis, and can be stimulated by PDGF-BB. Moreover, A. muciniphila treatment significantly reduced gut permeability and inflammation at the early stage. Dextran sulfate sodium (DSS) was used to disrupt the gut barrier to determine its role in fracture healing and whether A. muciniphila still can stimulate bone fracture healing. As expected, A. muciniphila evidently improved gut barrier, reduced inflammation and restored the impaired bone healing and angiogenesis in DSS-treated mice. Our results suggest that A. muciniphila reduces intestinal permeability and alleviates inflammation, which probably induces more PDGF-BB+ preosteoclasts and type H vessel formation in callus, thereby promoting fracture healing. This study provides the evidence for the involvement of type H vessels in fracture healing and suggests the potential of A. muciniphila as a promising strategy for bone healing.This article has an associated First Person interview with the first author of the paper.

Ultrasonic Diagnosis for Bone Fracture Healing Process

2020 ◽  
Author(s):  
Satoshi Kimura ◽  
Keisuke Oe ◽  
Yohei Kumabe ◽  
Tomoaki Fukui ◽  
Takahiro Niikura ◽  
...  
Keyword(s):  
Fracture Healing ◽  
Bone Fracture ◽  
Healing Process ◽  
Ultrasonic Diagnosis ◽  
Bone Fracture Healing

scholarly journals Diminished Callus Size and Cartilage Synthesis in α1β1 Integrin-Deficient Mice during Bone Fracture Healing

2002 ◽  
Vol 160 (5) ◽  
pp. 1779-1785 ◽  
Author(s):  
Erika Ekholm ◽  
Kurt D. Hankenson ◽  
Hannele Uusitalo ◽  
Ari Hiltunen ◽  
Humphrey Gardner ◽  
...  
Keyword(s):  
Fracture Healing ◽  
Bone Fracture ◽  
Bone Fracture Healing ◽  
Callus Size ◽  
Deficient Mice ◽  
And Cartilage

scholarly journals Differentiation mechanisms of regeneration blastema cells during bone fracture healing

2018 ◽  
Vol 0 (2) ◽  
pp. 78-86
Author(s):  
Alexey Popsuishapka ◽  
Valeriy Litvishko ◽  
Nataliya Ashukina ◽  
Vitaliy Grigoryev ◽  
Olga Pidgaiska
Keyword(s):  
Fracture Healing ◽  
Bone Fracture ◽  
Bone Fracture Healing ◽  
Regeneration Blastema

scholarly journals Effect of ultrasound on bone fracture healing: A computational bioregulatory model

2018 ◽  
Vol 100 ◽  
pp. 74-85 ◽  
Author(s):  
Maria G. Vavva ◽  
Konstantinos N. Grivas ◽  
Aurélie Carlier ◽  
Demosthenes Polyzos ◽  
Liesbet Geris ◽  
...  
Keyword(s):  
Fracture Healing ◽  
Bone Fracture ◽  
Bone Fracture Healing
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