scholarly journals Characterization of TransgenicGfrpKnock-In Mice: Implications for Tetrahydrobiopterin in Modulation of Normal Tissue Radiation Responses

2014 ◽  
Vol 20 (9) ◽  
pp. 1436-1446 ◽  
Author(s):  
Rupak Pathak ◽  
Snehalata A. Pawar ◽  
Qiang Fu ◽  
Prem K. Gupta ◽  
Maaike Berbée ◽  
...  
Keyword(s):  
Normal Tissue

scholarly journals T2*-weighted fMRI time-to-peak of oxygen challenge in ischemic stroke

2015 ◽  
Vol 36 (2) ◽  
pp. 283-291 ◽  
Author(s):  
Qiang Shen ◽  
Shiliang Huang ◽  
Timothy Q Duong
Keyword(s):  
At Risk ◽  
Ischemic Stroke ◽  
Normal Tissue ◽  
Time Course ◽  
Initial Increase ◽  
Vascular Density ◽  
Time To Peak ◽  
Ischemic Tissue ◽  
Apparent Diffusion

T2*-weighted MRI of transient oxygen challenge (OC) showed exaggerated OC percent changes in the ischemic tissue at risk compared to normal tissue. One ambiguity is that regions with high vascular density also showed exaggerated OC percent changes. This study explored time-to-peak (TTP) of the OC percent changes to improve the utility of T2*-weighted OC MRI. Experiments were performed longitudinally at 30 min, 150 min and 24 h after transient (60-min) stroke in rats. Ischemic core, normal, and mismatch tissue were classified pixel-by-pixel based on apparent diffusion coefficient and cerebral blood flow. Major findings were: (i) Delayed OC TTP was localized to and corresponded well with the perfusion-diffusion mismatch. (ii) By contrast, the exaggerated OC percent changes were less localized, with changes not only in the at-risk tissue but also in some areas of the contralesional hemisphere with venous vessel origins. (iii) The OC time-course of the mismatch tissue was biphasic, with a faster initial increase followed by a slower increase. (iv) At-risk tissue with delayed TTP and exaggerated OC was normal after reperfusion and the at-risk tissue was mostly (83 ± 18%) rescued by reperfusion as indicated by normal 24-h T2. OC TTP offers unique information toward better characterization of at-risk tissue in ischemic stroke.

Characterization of the Human Tumor and Normal Tissue Reactivity of the KS1/4 Monoclonal Antibody

Hybridoma ◽  
1988 ◽  
Vol 7 (4) ◽  
pp. 407-415 ◽  
Author(s):  
THOMAS F. BUMOL ◽  
PHILIP MARDER ◽  
SONJA V. DeHERDT ◽  
MICHAEL J. BOROWITZ ◽  
LYNN D. APELGREN
Keyword(s):  
Monoclonal Antibody ◽  
Normal Tissue ◽  
Human Tumor ◽  
Tissue Reactivity

Characterization of cancer and normal tissue fluorescence through wavelet transform and singular value decomposition

2008 ◽  
Author(s):  
Anita H. Gharekhan ◽  
Nrusingh C. Biswal ◽  
Sharad Gupta ◽  
Asima Pradhan ◽  
M. B. Sureshkumar ◽  
...  
Keyword(s):  
Wavelet Transform ◽  
Singular Value Decomposition ◽  
Normal Tissue ◽  
Singular Value ◽  
Tissue Fluorescence ◽  
Value Decomposition

scholarly journals Characterization of four subtypes in morphologically normal tissue excised proximal and distal to breast cancer

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Emanuela Gadaleta ◽  
Pauline Fourgoux ◽  
Stefano Pirró ◽  
Graeme J. Thorn ◽  
Rachel Nelan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Normal Tissue

Differentiating human cervical dysplastic and normal tissue through wavelet domain characterization of intrinsic fluorescence

2011 ◽  
Author(s):  
Rajatesh Gudibande ◽  
Meghdoot Mozumder ◽  
Rajbeer Singh ◽  
Prasanta K. Panigrahi ◽  
Sharad Gupta ◽  
...  
Keyword(s):  
Normal Tissue ◽  
Intrinsic Fluorescence ◽  
Wavelet Domain

scholarly journals CpG Island Methylation in Colorectal Cancer: Past, Present and Future

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Karen Curtin ◽  
Martha L. Slattery ◽  
Wade S. Samowitz
Keyword(s):  
Colorectal Cancer ◽  
Normal Tissue ◽  
Cpg Island ◽  
Cpg Island Methylator Phenotype ◽  
New Directions ◽  
Widespread Acceptance ◽  
Cpg Island Methylation ◽  
Methylator Phenotype ◽  
Cancer Studies

The concept of a CpG island methylator phenotype, or CIMP, quickly became the focus of several colorectal cancer studies describing its clinical and pathological features after its introduction in 1999 by Toyota and colleagues. Further characterization of CIMP in tumors lead to widespread acceptance of the concept, as expressed by Shen and Issa in their 2005 editorial, “CIMP, at last.” Since that time, extensive research efforts have brought great insights into the epidemiology and prognosis of CIMP+ tumors and other epigenetic mechanisms underlying tumorigenesis. With the advances in technology and subsequent cataloging of the human methylome in cancer and normal tissue, new directions in research to understand CIMP and its role in complex biological systems yield hope for future epigenetically based diagnostics and treatments.

Quantitative characterization of airspace enlargement in emphysema

2006 ◽  
Vol 100 (1) ◽  
pp. 186-193 ◽  
Author(s):  
Harikrishnan Parameswaran ◽  
Arnab Majumdar ◽  
Satoru Ito ◽  
Adriano M. Alencar ◽  
Béla Suki
Keyword(s):  
Normal Tissue ◽  
Equivalent Diameter ◽  
Quantitative Characterization ◽  
Large Variability ◽  
Tissue Sections ◽  
Automated Method ◽  
Linear Dimensions ◽  
Mean Linear Intercept ◽  
The Mean

The mean linear intercept ( Lm) can be used to estimate the surface area for gas exchange in the lung. However, in recent years, it is most commonly used as an index for characterizing the enlargement of airspaces in emphysema and the associated severity of structural destruction in the lung. Specifically, an increase in Lm is thought to result from an increase in airspace sizes. In this paper, we examined how accurately Lm measures the linear dimensions of airspaces from histological sections and a variety of computer-generated test images. To this end, we developed an automated method for measuring linear intercepts from digitized images of tissue sections and calculate Lm as their mean. We examined how the shape of airspaces and the variability of their sizes influence Lm as well as the distribution of linear intercepts. We found that, for a relatively homogeneous enlargement of airspaces, Lm was a reliable index for detecting emphysema. However, in the presence of spatial heterogeneities with a large variability of airspace sizes, Lm did not significantly increase and sometimes even decreased compared with its value in normal tissue. We also developed an automated method for measuring the area and computed an equivalent diameter of each individual airspace that is independent of shape. Finally, we introduced new indexes based on the moments of diameter that we found to be more reliable than Lm to characterize airspace enlargement in the presence of heterogeneities.

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