Free and Acid-Labile Hydrogen Sulfide Concentrations in Mouse Tissues: Anomalously High Free Hydrogen Sulfide in Aortic Tissue

2011 ◽  
Vol 15 (2) ◽  
pp. 373-378 ◽  
Author(s):  
Michael D. Levitt ◽  
Mohamed Saber Abdel-Rehim ◽  
Julie Furne
Keyword(s):  
Hydrogen Sulfide ◽  
Aortic Tissue ◽  
Labile Hydrogen ◽  
Mouse Tissues ◽  
Free Hydrogen ◽  
Acid Labile

Stimulation of the endogenous hydrogen sulfide synthesis suppresses oxidative–nitrosative stress and restores endothelial-dependent vasorelaxation in old rats

2020 ◽  
Vol 98 (5) ◽  
pp. 275-281 ◽  
Author(s):  
L.A. Mys ◽  
N.A. Strutynska ◽  
Y.V. Goshovska ◽  
V.F. Sagach
Keyword(s):  
Nitric Oxide ◽  
Hydrogen Sulfide ◽  
Nitric Oxide Synthase ◽  
Vascular Reactivity ◽  
Nitrosative Stress ◽  
Rat Aorta ◽  
Aortic Tissue ◽  
Old Rats ◽  
Oxide Synthase ◽  
Stimulation Of

Hydrogen sulfide (H2S) is an endogenous gas transmitter with profound effects on the cardiovascular system. We hypothesized that stimulation of H2S synthesis might alleviate age-associated changes in vascular reactivity. Pyridoxal-5-phosphate (PLP), the coenzyme of H2S-synthesizing enzymes, was administrated to old male Wistar rats per os at a dose of 0.7 mg/kg body mass once a day for 2 weeks. H2S content in the aortic tissue, markers of oxidative stress, inducible nitric oxide synthase (iNOS) and constitutive nitric oxide synthase (cNOS), arginase activities, and endothelium-dependent vasorelaxation of the aortic rings were studied. Our results showed that PLP restored endogenous H2S and low molecular weight S-nitrosothiol levels in old rat aorta to the levels detected in adults. PLP significantly reduced diene conjugate content, hydrogen peroxide and peroxynitrite generation rates, and iNOS and arginase activity in the aortic tissue of old rats. PLP also greatly improved acetylcholine-induced relaxation of old rat aorta (47.7% ± 4.8% versus 18.4% ± 4.1% in old rats, P < 0.05) that was abolished by NO inhibition with N-nitro-l-arginine methyl ester hydrochloride (L-NAME) or H2S inhibition with O-carboxymethylhydroxylamine (O-CMH). Thus, PLP might be used for stimulation of endogenous H2S synthesis and correction of oxidative and nitrosative stress and vessel tone dysfunction in aging and age-associated diseases.

Effects of aspirin on the levels of hydrogen sulfide and sulfane sulfur in mouse tissues

2010 ◽  
Vol 62 (2) ◽  
pp. 304-310 ◽  
Author(s):  
Anna Bilska ◽  
Małgorzata Iciek ◽  
Inga Kwiecień ◽  
Karol Kaniecki ◽  
Magdalena Paliborek ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Sulfane Sulfur ◽  
Mouse Tissues

Plasma Free Hydrogen Sulfide is a Biomarker for Vascular Disease Incidence Compared to Nitric Oxide Metabolites

2012 ◽  
Vol 53 ◽  
pp. S174
Author(s):  
Elvis Peter ◽  
Xinggui Shen ◽  
Shivang Shah ◽  
Sibile Pardue ◽  
John D. Glawe ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Hydrogen Sulfide ◽  
Vascular Disease ◽  
Disease Incidence ◽  
Free Hydrogen ◽  
Nitric Oxide Metabolites

Relation of free hydrogen sulfide concentration and relaxation in rat small arteries

Nitric Oxide ◽  
2015 ◽  
Vol 47 ◽  
pp. S56
Author(s):  
Elise R. Hedegaard ◽  
Anja Gouliaev ◽  
Mathilde Aalling ◽  
Nirthika Sivasubramaniam ◽  
Nini Skovgaard ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Sulfide Concentration ◽  
Small Arteries ◽  
Free Hydrogen ◽  
Hydrogen Sulfide Concentration

Nickel-Free Hydrogen Sulfide Control Technology for European Applications

1993 ◽  
Author(s):  
R. G. Bending ◽  
M. R. Albert ◽  
M. J. D'Aniello ◽  
S. E. Golunski ◽  
A. F. Diwell ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Control Technology ◽  
Free Hydrogen ◽  
Sulfide Control

Microplate-Based Colorimetric Detection of Free Hydrogen Sulfide

2013 ◽  
Vol 85 (7) ◽  
pp. 3638-3643 ◽  
Author(s):  
Artur P. Jarosz ◽  
Terence Yep ◽  
Bulent Mutus
Keyword(s):  
Hydrogen Sulfide ◽  
Colorimetric Detection ◽  
Free Hydrogen
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