B- to Plasma-Cell Terminal Differentiation Entails Oxidative Stress and Profound Reshaping of the Antioxidant Responses

2010 ◽  
Vol 13 (8) ◽  
pp. 1133-1144 ◽  
Author(s):  
Milena Bertolotti ◽  
Sun Hee Yim ◽  
Jose M. Garcia-Manteiga ◽  
Silvia Masciarelli ◽  
Yoo-Jin Kim ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Plasma Cell ◽  
Terminal Differentiation ◽  
Antioxidant Responses

scholarly journals Uterine Deletion of Trp53 Compromises Antioxidant Responses in the Mouse Decidua

Endocrinology ◽  
2012 ◽  
Vol 153 (9) ◽  
pp. 4568-4579 ◽  
Author(s):  
Kristin E. Burnum ◽  
Yasushi Hirota ◽  
Erin S. Baker ◽  
Mikihiro Yoshie ◽  
Yehia M. Ibrahim ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Enzymes ◽  
Preterm Birth ◽  
Global Health ◽  
P53 Protein ◽  
Terminal Differentiation ◽  
Down Regulation ◽  
Antioxidant Responses ◽  
Global Health Issue ◽  
Potential Factors

Preterm birth is a global health issue impacting millions of mothers and babies. However, the etiology of preterm birth is not clearly understood. Our recent finding that premature decidual senescence with terminal differentiation is a cause of preterm birth in mice with uterine Trp53 deletion, encoding p53 protein, led us to explore other potential factors that are related to preterm birth. Using proteomics approaches, here, we show that 183 candidate proteins show significant changes in deciduae with Trp53 deletion as compared with normal deciduae. Functional categorization of these proteins unveiled new pathways that are influenced by p53. In particular, down-regulation of a cluster of antioxidant enzymes in p53-deficient deciduae suggests that increased oxidative stress could be one cause of preterm birth in mice harboring uterine deletion of Trp53.

scholarly journals N-acetyl-cysteine increases cellular dysfunction in progressive chronic kidney damage after acute kidney injury by dampening endogenous antioxidant responses

2018 ◽  
Vol 314 (5) ◽  
pp. F956-F968 ◽  
Author(s):  
David M. Small ◽  
Washington Y. Sanchez ◽  
Sandrine F. Roy ◽  
Christudas Morais ◽  
Heddwen L. Brooks ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Acute Kidney Injury ◽  
Mitochondrial Dysfunction ◽  
Transforming Growth Factor ◽  
Multiphoton Microscopy ◽  
Kidney Injury ◽  
Peroxisome Proliferator ◽  
Fluorescence Lifetime Imaging ◽  
Antioxidant Responses ◽  
Acetyl Cysteine

Oxidative stress and mitochondrial dysfunction exacerbate acute kidney injury (AKI), but their role in any associated progress to chronic kidney disease (CKD) remains unclear. Antioxidant therapies often benefit AKI, but their benefits in CKD are controversial since clinical and preclinical investigations often conflict. Here we examined the influence of the antioxidant N-acetyl-cysteine (NAC) on oxidative stress and mitochondrial function during AKI (20-min bilateral renal ischemia plus reperfusion/IR) and progression to chronic kidney pathologies in mice. NAC (5% in diet) was given to mice 7 days prior and up to 21 days post-IR (21d-IR). NAC treatment resulted in the following: prevented proximal tubular epithelial cell apoptosis at early IR (40-min postischemia), yet enhanced interstitial cell proliferation at 21d-IR; increased transforming growth factor-β1 expression independent of IR time; and significantly dampened nuclear factor-like 2-initiated cytoprotective signaling at early IR. In the long term, NAC enhanced cellular metabolic impairment demonstrated by increased peroxisome proliferator activator-γ serine-112 phosphorylation at 21d-IR. Intravital multiphoton microscopy revealed increased endogenous fluorescence of nicotinamide adenine dinucleotide (NADH) in cortical tubular epithelial cells during ischemia, and at 21d-IR that was not attenuated with NAC. Fluorescence lifetime imaging microscopy demonstrated persistent metabolic impairment by increased free/bound NADH in the cortex at 21d-IR that was enhanced by NAC. Increased mitochondrial dysfunction in remnant tubular cells was demonstrated at 21d-IR by tetramethylrhodamine methyl ester fluorimetry. In summary, NAC enhanced progression to CKD following AKI not only by dampening endogenous cellular antioxidant responses at time of injury but also by enhancing persistent kidney mitochondrial and metabolic dysfunction.

Salt tolerance of the halophyte Limonium delicatulum is more associated with antioxidant enzyme activities than phenolic compounds

2016 ◽  
Vol 43 (7) ◽  
pp. 607 ◽  
Author(s):  
Souid Aymen ◽  
Gabriele Morena ◽  
Longo Vincenzo ◽  
Pucci Laura ◽  
Bellani Lorenza ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Photosynthetic Performance ◽  
Polyphenolic Compounds ◽  
Antioxidant Enzyme Activities ◽  
Strongly Correlated ◽  
Growth Responses ◽  
Antioxidant Responses ◽  
Stress Markers ◽  
Biochemical Assays ◽  
Nacl Concentration

In this work we studied the effect of salinity (ranging from 50 to 500 mM NaCl) on the physiological and the antioxidant responses of the local halophyte Limonium delicatulum Kuntze. We based our analysis on 12 biochemical assays that are commonly used to measure the antioxidant responses under stress such as oxidative stress markers, enzymes activities and polyphenolic compounds. Our aim was to study parameters that are strongly correlated with the growth response to salinity. Results showed two different growth responses depending on the concentration of NaCl in the medium. Under 50 to 200 mM, the growth was stimulated before it decreased significantly at 300–500 mM. L. delicatulum revealed a good aptitude to maintain photosynthetic machinery by increasing the concentrations of photosynthetic pigments, which is essential for the stabilisation of photosystems and the photosynthesis process under optimal NaCl concentration. Their breakdown at higher salinity decreased the photosynthetic performance of plants resulting in growth inhibition. Moreover, to reduce the damaging effect of oxidative stress and to tolerate the accumulation of salt ions, L. delicatulum induced the activities of their antioxidant enzymes more than their contents in polyphenolic compounds.

Oxidative stress and enzymic–non-enzymic antioxidant responses in children with acute pneumonia

2006 ◽  
Vol 24 (3) ◽  
pp. 269-273 ◽  
Author(s):  
Mustafa Cemek ◽  
Hüseyin Çaksen ◽  
Fahri Bayiroğlu ◽  
Fatma Cemek ◽  
Semiha Dede
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Responses ◽  
Acute Pneumonia

Sublethal toxicity of quinalphos on oxidative stress and antioxidant responses in a freshwater fishCyprinus carpio

2015 ◽  
Vol 31 (11) ◽  
pp. 1399-1406 ◽  
Author(s):  
Devan Hemalatha ◽  
Antony Amala ◽  
Basuvannan Rangasamy ◽  
Bojan Nataraj ◽  
Mathan Ramesh
Keyword(s):  
Oxidative Stress ◽  
Sublethal Toxicity ◽  
Antioxidant Responses

scholarly journals Antioxidant responses and plasma biochemical characteristics in the freshwater rainbow trout, Oncorhynchus mykiss, after acute exposure to the fungicide propiconazole

2011 ◽  
Vol 56 (No. 2) ◽  
pp. 61-69 ◽  
Author(s):  
Z.-H. Li ◽  
V. Zlabek ◽  
J. Velíšek ◽  
R. Grabic ◽  
J. Machová ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rainbow Trout ◽  
Oncorhynchus Mykiss ◽  
Control Group ◽  
Antioxidant Responses ◽  
Stress Indices ◽  
Rainbow Trout Oncorhynchus Mykiss ◽  
Plasma Enzymes ◽  
Plasma Characteristics ◽  
The Brain

In this study, the toxic effects of PCZ, a triazole fungicide present in aquatic environment, were studied in rainbow trout, Oncorhynchus mykiss, by an acute toxicity test. Compared to the control group, fish exposed to PCZ (96-h-LC50, 5.04 mg/l) showed significantly higher (P < 0.05) plasma NH3 and GLU concentration and the activities of plasma enzymes including CK, ALT, AST, LDH, but the TP content was not significantly different (P > 0.05). The oxidative stress indices (levels of LPO and CP) of brain and muscle in the experimental group were higher compared to the control group, especially for a significant change (P < 0.05) in the brain. SOD, CAT, GPx and GR activity in the brain of experimental groups was significantly lower (P < 0.05), however, an opposite tendency was found out in muscle. In addition, there are significant correlations between TBARS and CAT, TBARS and GPx, CP, and CAT, GR, and GPx in the fish brain. Thus, PCZ exposure changed the oxidative stress indices and plasma characteristics, and these changes may be used as potential bioindicators of the exposure and effect of PCZ in the controlled experiment. The use in monitoring of PCZ exposure under natural field conditions is possible, but it needs further investigations.

Effects of the acute exposition to glyphosate-based herbicide on oxidative stress parameters and antioxidant responses in a hybrid Amazon fish surubim (Pseudoplatystoma sp)

2014 ◽  
Vol 106 ◽  
pp. 181-187 ◽  
Author(s):  
Valéria Dornelles Gindri Sinhorin ◽  
Adilson Paulo Sinhorin ◽  
Jhonnes Marcos dos Santos Teixeira ◽  
Kelly Márcia Lazarotto Miléski ◽  
Paula Carine Hansen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Responses ◽  
Oxidative Stress Parameters ◽  
Amazon Fish ◽  
Stress Parameters

scholarly journals Effect of Chromium on Antioxidant Potential ofCatharanthus roseusVarieties and Production of Their Anticancer Alkaloids: Vincristine and Vinblastine

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Vartika Rai ◽  
Pramod Kumar Tandon ◽  
Sayyada Khatoon
Keyword(s):  
Oxidative Stress ◽  
Indole Alkaloids ◽  
Culture Conditions ◽  
Antioxidant Potential ◽  
Terpenoid Indole Alkaloids ◽  
Protective Mechanisms ◽  
Important Place ◽  
Antioxidant Responses ◽  
Active Constituents ◽  
Pot Culture

Catharanthus roseus(L.) G. Don, a medicinal plant, has a very important place in the traditional as well as modern pharmaceutical industry. Two common varieties of this plantroseaandalbaare named so because of pink and white coloured flowers, respectively. This plant comprises of about 130 terpenoid indole alkaloids and two of them, vincristine and vinblastine, are common anticancer drugs. The effect of chromium (Cr) on enzymatic and non-enzymatic antioxidant components and on secondary metabolites vincristine and vinblastine was studied under pot culture conditions of both varieties ofC. roseus. Antioxidant responses of these varieties were analyzed under 0, 10, 50, and 100 μM chromium (Cr) level in order to investigate the plant’s protective mechanisms against Cr induced oxidative stress. The results indicated that Cr affects all the studied parameters and decreases growth performance. However, vincristine and vinblastine contents were increased under Cr stress. Results are quite encouraging, as this plant shows good antioxidant potential and increased the level of active constituents under Cr stress.

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