Protective Role of Heme Oxygenase-1 Against Liver Damage Caused by Hepatic Ischemia and Reperfusion in Rats

2010 ◽  
Vol 13 (10) ◽  
pp. 1503-1512 ◽  
Author(s):  
Nari Yun ◽  
Hyun-Ae Eum ◽  
Sun-Mee Lee
Keyword(s):  
Heme Oxygenase ◽  
Liver Damage ◽  
Protective Role ◽  
Heme Oxygenase 1 ◽  
Ischemia And Reperfusion ◽  
Hepatic Ischemia

scholarly journals A Dual Role of Heme Oxygenase-1 in Cancer Cells

2018 ◽  
Vol 20 (1) ◽  
pp. 39 ◽  
Author(s):  
Shih-Kai Chiang ◽  
Shuen-Ei Chen ◽  
Ling-Chu Chang
Keyword(s):  
Cell Death ◽  
Heme Oxygenase ◽  
Cancer Progression ◽  
Critical Role ◽  
Causative Factor ◽  
Protective Role ◽  
Dark Side ◽  
Heme Oxygenase 1 ◽  
Cellular Iron

Heme oxygenase (HO)-1 is known to metabolize heme into biliverdin/bilirubin, carbon monoxide, and ferrous iron, and it has been suggested to demonstrate cytoprotective effects against various stress-related conditions. HO-1 is commonly regarded as a survival molecule, exerting an important role in cancer progression and its inhibition is considered beneficial in a number of cancers. However, increasing studies have shown a dark side of HO-1, in which HO-1 acts as a critical mediator in ferroptosis induction and plays a causative factor for the progression of several diseases. Ferroptosis is a newly identified iron- and lipid peroxidation-dependent cell death. The critical role of HO-1 in heme metabolism makes it an important candidate to mediate protective or detrimental effects via ferroptosis induction. This review summarizes the current understanding on the regulatory mechanisms of HO-1 in ferroptosis. The amount of cellular iron and reactive oxygen species (ROS) is the determinative momentum for the role of HO-1, in which excessive cellular iron and ROS tend to enforce HO-1 from a protective role to a perpetrator. Despite the dark side that is related to cell death, there is a prospective application of HO-1 to mediate ferroptosis for cancer therapy as a chemotherapeutic strategy against tumors.

scholarly journals Autophagic proteins regulate cigarette smoke induced apoptosis: Protective role of heme oxygenase-1

Autophagy ◽  
2008 ◽  
Vol 4 (7) ◽  
pp. 887-895 ◽  
Author(s):  
Hong Pyo Kim ◽  
Xue Wang ◽  
Seon-Jin Lee ◽  
Min-Hsin Huang ◽  
Yong Wan ◽  
...  
Keyword(s):  
Cigarette Smoke ◽  
Heme Oxygenase ◽  
Protective Role ◽  
Heme Oxygenase 1 ◽  
Induced Apoptosis ◽  
Autophagic Proteins

PROTECTIVE ROLE OF HEME OXYGENASE 1 IN THE INTESTINAL TISSUE INJURY IN HEMORRHAGIC SHOCK IN RATS

Shock ◽  
2008 ◽  
Vol 29 (2) ◽  
pp. 252-261 ◽  
Author(s):  
Kazuyoshi Inoue ◽  
Toru Takahashi ◽  
Kenji Uehara ◽  
Hiroko Shimuzu ◽  
Kana Ido ◽  
...  
Keyword(s):  
Hemorrhagic Shock ◽  
Heme Oxygenase ◽  
Tissue Injury ◽  
Protective Role ◽  
Heme Oxygenase 1 ◽  
Intestinal Tissue

scholarly journals Inductive transcription and protective role of fish heme oxygenase-1 under hypoxic stress

2008 ◽  
Vol 211 (16) ◽  
pp. 2700-2706 ◽  
Author(s):  
D. Wang ◽  
X.-P. Zhong ◽  
Z.-X. Qiao ◽  
J.-F. Gui
Keyword(s):  
Heme Oxygenase ◽  
Protective Role ◽  
Heme Oxygenase 1 ◽  
Hypoxic Stress
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