scholarly journals Autophagic proteins regulate cigarette smoke induced apoptosis: Protective role of heme oxygenase-1

Autophagy ◽  
2008 ◽  
Vol 4 (7) ◽  
pp. 887-895 ◽  
Author(s):  
Hong Pyo Kim ◽  
Xue Wang ◽  
Seon-Jin Lee ◽  
Min-Hsin Huang ◽  
Yong Wan ◽  
...  
Keyword(s):  
Cigarette Smoke ◽  
Heme Oxygenase ◽  
Protective Role ◽  
Heme Oxygenase 1 ◽  
Induced Apoptosis ◽  
Autophagic Proteins

scholarly journals A Dual Role of Heme Oxygenase-1 in Cancer Cells

2018 ◽  
Vol 20 (1) ◽  
pp. 39 ◽  
Author(s):  
Shih-Kai Chiang ◽  
Shuen-Ei Chen ◽  
Ling-Chu Chang
Keyword(s):  
Cell Death ◽  
Heme Oxygenase ◽  
Cancer Progression ◽  
Critical Role ◽  
Causative Factor ◽  
Protective Role ◽  
Dark Side ◽  
Heme Oxygenase 1 ◽  
Cellular Iron

Heme oxygenase (HO)-1 is known to metabolize heme into biliverdin/bilirubin, carbon monoxide, and ferrous iron, and it has been suggested to demonstrate cytoprotective effects against various stress-related conditions. HO-1 is commonly regarded as a survival molecule, exerting an important role in cancer progression and its inhibition is considered beneficial in a number of cancers. However, increasing studies have shown a dark side of HO-1, in which HO-1 acts as a critical mediator in ferroptosis induction and plays a causative factor for the progression of several diseases. Ferroptosis is a newly identified iron- and lipid peroxidation-dependent cell death. The critical role of HO-1 in heme metabolism makes it an important candidate to mediate protective or detrimental effects via ferroptosis induction. This review summarizes the current understanding on the regulatory mechanisms of HO-1 in ferroptosis. The amount of cellular iron and reactive oxygen species (ROS) is the determinative momentum for the role of HO-1, in which excessive cellular iron and ROS tend to enforce HO-1 from a protective role to a perpetrator. Despite the dark side that is related to cell death, there is a prospective application of HO-1 to mediate ferroptosis for cancer therapy as a chemotherapeutic strategy against tumors.

PROTECTIVE ROLE OF HEME OXYGENASE 1 IN THE INTESTINAL TISSUE INJURY IN HEMORRHAGIC SHOCK IN RATS

Shock ◽  
2008 ◽  
Vol 29 (2) ◽  
pp. 252-261 ◽  
Author(s):  
Kazuyoshi Inoue ◽  
Toru Takahashi ◽  
Kenji Uehara ◽  
Hiroko Shimuzu ◽  
Kana Ido ◽  
...  
Keyword(s):  
Hemorrhagic Shock ◽  
Heme Oxygenase ◽  
Tissue Injury ◽  
Protective Role ◽  
Heme Oxygenase 1 ◽  
Intestinal Tissue

scholarly journals Inductive transcription and protective role of fish heme oxygenase-1 under hypoxic stress

2008 ◽  
Vol 211 (16) ◽  
pp. 2700-2706 ◽  
Author(s):  
D. Wang ◽  
X.-P. Zhong ◽  
Z.-X. Qiao ◽  
J.-F. Gui
Keyword(s):  
Heme Oxygenase ◽  
Protective Role ◽  
Heme Oxygenase 1 ◽  
Hypoxic Stress

scholarly journals The Protective Role of Heme Oxygenase-1 in Atherosclerotic Diseases

2019 ◽  
Vol 20 (15) ◽  
pp. 3628 ◽  
Author(s):  
Yoshimi Kishimoto ◽  
Kazuo Kondo ◽  
Yukihiko Momiyama
Keyword(s):  
Animal Models ◽  
Heme Oxygenase ◽  
Protective Role ◽  
Heme Oxygenase 1 ◽  
Intracellular Enzyme ◽  
Anti Oxidant ◽  
Low Levels ◽  
Artery Disease ◽  
Accelerate Atherosclerosis

Heme oxygenase-1 (HO-1) is an intracellular enzyme that catalyzes the oxidation of heme to generate ferrous iron, carbon monoxide (CO), and biliverdin, which is subsequently converted to bilirubin. These products have anti-inflammatory, anti-oxidant, anti-apoptotic, and anti-thrombotic properties. Although HO-1 is expressed at low levels in most tissues under basal conditions, it is highly inducible in response to various pathophysiological stresses/stimuli. HO-1 induction is thus thought to be an adaptive defense system that functions to protect cells and tissues against injury in many disease settings. In atherosclerosis, HO-1 may play a protective role against the progression of atherosclerosis, mainly due to the degradation of pro-oxidant heme, the generation of anti-oxidants biliverdin and bilirubin and the production of vasodilator CO. In animal models, a lack of HO-1 was shown to accelerate atherosclerosis, whereas HO-1 induction reduced atherosclerosis. It was also reported that HO-1 induction improved the cardiac function and postinfarction survival in animal models of heart failure or myocardial infarction. Recently, we and others examined blood HO-1 levels in patients with atherosclerotic diseases, e.g., coronary artery disease (CAD) and peripheral artery disease (PAD). Taken together, these findings to date support the notion that HO-1 plays a protective role against the progression of atherosclerotic diseases. This review summarizes the roles of HO-1 in atherosclerosis and focuses on the clinical studies that examined the relationships between HO-1 levels and atherosclerotic diseases.

Expression and Protective Role of Heme Oxygenase-1 in Delayed Myocardial Preconditioning

2007 ◽  
Vol 1095 (1) ◽  
pp. 251-261 ◽  
Author(s):  
G. JANCSO ◽  
B. CSEREPES ◽  
B. GASZ ◽  
L. BENKO ◽  
B. BORSICZKY ◽  
...  
Keyword(s):  
Heme Oxygenase ◽  
Protective Role ◽  
Heme Oxygenase 1 ◽  
Myocardial Preconditioning

The Protective Role of Heme Oxygenase-1 in Cerebral Ischemia

2010 ◽  
Vol 10 (4) ◽  
pp. 310-316 ◽  
Author(s):  
Emmanuel Aztatzi-Santillan ◽  
Felipe Eduardo Nares-Lopez ◽  
Berenice Marquez-Valadez ◽  
Penelope Aguilera ◽  
Maria Elena Chanez-Cardenas
Keyword(s):  
Cerebral Ischemia ◽  
Heme Oxygenase ◽  
Protective Role ◽  
Heme Oxygenase 1
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