scholarly journals Hyperoxia, Endothelial Progenitor Cell Mobilization, and Diabetic Wound Healing

2008 ◽  
Vol 10 (11) ◽  
pp. 1869-1882 ◽  
Author(s):  
Zhao-Jun Liu ◽  
Omaida C. Velazquez
Keyword(s):  
Wound Healing ◽  
Endothelial Progenitor Cell ◽  
Progenitor Cell ◽  
Diabetic Wound ◽  
Endothelial Progenitor ◽  
Diabetic Wound Healing ◽  
Cell Mobilization

535-P: Neurotensin Improves Endothelial Progenitor Cell Function in Diabetic Wound Healing

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 535-P
Author(s):  
ERMELINDO C. LEAL ◽  
ANA FIGUEIREDO ◽  
EUGENIA CARVALHO
Keyword(s):  
Wound Healing ◽  
Endothelial Progenitor Cell ◽  
Progenitor Cell ◽  
Cell Function ◽  
Diabetic Wound ◽  
Endothelial Progenitor ◽  
Diabetic Wound Healing

Insulin modulates ischemia-induced endothelial progenitor cell mobilization and neovascularization in diabetic mice

2011 ◽  
Vol 82 (3) ◽  
pp. 227-236 ◽  
Author(s):  
Li Dong ◽  
Lina Kang ◽  
Liang Ding ◽  
Qin Chen ◽  
Jian Bai ◽  
...  
Keyword(s):  
Endothelial Progenitor Cell ◽  
Progenitor Cell ◽  
Diabetic Mice ◽  
Endothelial Progenitor ◽  
Cell Mobilization

scholarly journals Platelet-Rich Plasma with Endothelial Progenitor Cells Accelerates Diabetic Wound Healing in Rats by Upregulating the Notch1 Signaling Pathway

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Cheng Zhang ◽  
Yu Zhu ◽  
Shengdi Lu ◽  
Wanrun Zhong ◽  
Yanmao Wang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Growth Factors ◽  
Signaling Pathway ◽  
Platelet Rich Plasma ◽  
Diabetic Wound ◽  
Endothelial Progenitor ◽  
Notch1 Signaling ◽  
Diabetic Wound Healing ◽  
Notch1 Signaling Pathway ◽  
Diabetic Wounds

Diabetic wounds, as a kind of refractory wound, are very difficult to heal. Both endothelial progenitor cell (EPC) transplantation and platelet-rich plasma (PRP) can improve diabetic wound healing to some extent. However, PRP application cannot provide reparative cells, while EPC transplantation cannot replenish the required growth factors for wound healing. Thus, when applied alone, neither of these factors is sufficient for effective wound healing. Furthermore, the proliferation, differentiation, and fate of the transplanted EPCs are not well known. Therefore, in this study, we examined the efficacy of combined PRP application with EPC transplantation in diabetic wound healing. Our results indicated that PRP application improved EPC proliferation and migration. The Notch signaling pathway plays a key role in the regulation of the proliferation and differentiation of stem cells and angiogenesis in wound healing. The application of PRP upregulated the Notch pathway-related gene and protein expression in EPCs. Furthermore, experiments with shNotch1-transfected EPCs indicated that PRP enhanced the function of EPCs by upregulating the Notch1 signaling pathway. In vivo studies further indicated that the combination of PRP and EPC transplantation increased neovascularization, reduced wound size, and improved healing in rat wound models. Thus, PRP application can provide the necessary growth factors for wound healing, while EPC transplantation offers the required cells, indicating that the combination of both is a potent novel approach for treating diabetic wounds.

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