scholarly journals miRNA-221-3p in Endothelial Progenitor Cell-Derived Exosomes Accelerates Skin Wound Healing in Diabetic Mice

2020 ◽  
Vol Volume 13 ◽  
pp. 1259-1270 ◽  
Author(s):  
Juan Xu ◽  
Suwen Bai ◽  
Yadi Cao ◽  
Lei Liu ◽  
Yang Fang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Endothelial Progenitor Cell ◽  
Progenitor Cell ◽  
Skin Wound ◽  
Diabetic Mice ◽  
Endothelial Progenitor ◽  
Skin Wound Healing

CCL5–CCR5 axis mediates skin wound healing by promoting endothelial progenitor cell accumulation

Cytokine ◽  
2009 ◽  
Vol 48 (1-2) ◽  
pp. 115
Author(s):  
Yuko Ishida ◽  
Akihiko Kimura ◽  
Masanori Inui ◽  
Yumi Kuninaka ◽  
Kouji Matsushima ◽  
...  
Keyword(s):  
Wound Healing ◽  
Endothelial Progenitor Cell ◽  
Progenitor Cell ◽  
Skin Wound ◽  
Endothelial Progenitor ◽  
Skin Wound Healing ◽  
Cell Accumulation

scholarly journals Keratin Scaffolds Containing Casomorphin Stimulate Macrophage Infiltration and Accelerate Full-Thickness Cutaneous Wound Healing in Diabetic Mice

Molecules ◽  
2021 ◽  
Vol 26 (9) ◽  
pp. 2554
Author(s):  
Marek Konop ◽  
Anna K. Laskowska ◽  
Mateusz Rybka ◽  
Ewa Kłodzińska ◽  
Dorota Sulejczak ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Healing Process ◽  
Skin Wound ◽  
Wound Healing Process ◽  
Diabetic Mice ◽  
Full Thickness ◽  
Skin Wound Healing ◽  
Impaired Wound Healing

Impaired wound healing is a major medical challenge, especially in diabetics. Over the centuries, the main goal of tissue engineering and regenerative medicine has been to invent biomaterials that accelerate the wound healing process. In this context, keratin-derived biomaterial is a promising candidate due to its biocompatibility and biodegradability. In this study, we evaluated an insoluble fraction of keratin containing casomorphin as a wound dressing in a full-thickness surgical skin wound model in mice (n = 20) with iatrogenically induced diabetes. Casomorphin, an opioid peptide with analgesic properties, was incorporated into keratin and shown to be slowly released from the dressing. An in vitro study showed that keratin-casomorphin dressing is biocompatible, non-toxic, and supports cell growth. In vivo experiments demonstrated that keratin-casomorphin dressing significantly (p < 0.05) accelerates the whole process of skin wound healing to the its final stage. Wounds covered with keratin-casomorphin dressing underwent reepithelization faster, ending up with a thicker epidermis than control wounds, as confirmed by histopathological and immunohistochemical examinations. This investigated dressing stimulated macrophages infiltration, which favors tissue remodeling and regeneration, unlike in the control wounds in which neutrophils predominated. Additionally, in dressed wounds, the number of microhemorrhages was significantly decreased (p < 0.05) as compared with control wounds. The dressing was naturally incorporated into regenerating tissue during the wound healing process. Applied keratin dressing favored reconstruction of more regular skin structure and assured better cosmetic outcome in terms of scar formation and appearance. Our results have shown that insoluble keratin wound dressing containing casomorphin supports skin wound healing in diabetic mice.

Insulin modulates ischemia-induced endothelial progenitor cell mobilization and neovascularization in diabetic mice

2011 ◽  
Vol 82 (3) ◽  
pp. 227-236 ◽  
Author(s):  
Li Dong ◽  
Lina Kang ◽  
Liang Ding ◽  
Qin Chen ◽  
Jian Bai ◽  
...  
Keyword(s):  
Endothelial Progenitor Cell ◽  
Progenitor Cell ◽  
Diabetic Mice ◽  
Endothelial Progenitor ◽  
Cell Mobilization

scholarly journals The bone marrow-derived endothelial progenitor cell response is impaired in delayed wound healing from ischemia

2006 ◽  
Vol 43 (1) ◽  
pp. 134-141 ◽  
Author(s):  
Stephen M. Bauer ◽  
Lee J. Goldstein ◽  
Richard J. Bauer ◽  
Haiying Chen ◽  
Mary Putt ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Wound Healing ◽  
Endothelial Progenitor Cell ◽  
Cell Response ◽  
Progenitor Cell ◽  
Endothelial Progenitor ◽  
Delayed Wound Healing

Mechanism of angiopoietin-1 mediated endothelial progenitor cell recruitment in wound healing

2004 ◽  
Vol 199 (3) ◽  
pp. 60
Author(s):  
Sundeep G. Keswani ◽  
Jignesh K. Parvadia ◽  
David Stitelman ◽  
Elliot D. Kozin ◽  
Antoneta P. Radu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Endothelial Progenitor Cell ◽  
Progenitor Cell ◽  
Endothelial Progenitor ◽  
Cell Recruitment ◽  
Angiopoietin 1

scholarly journals CCL2-Mediated Reversal of Impaired Skin Wound Healing in Diabetic Mice by Normalization of Neovascularization and Collagen Accumulation

2019 ◽  
Vol 139 (12) ◽  
pp. 2517-2527.e5 ◽  
Author(s):  
Yuko Ishida ◽  
Yumi Kuninaka ◽  
Mizuho Nosaka ◽  
Machi Furuta ◽  
Akihiko Kimura ◽  
...  
Keyword(s):  
Wound Healing ◽  
Skin Wound ◽  
Diabetic Mice ◽  
Skin Wound Healing ◽  
Collagen Accumulation
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