scholarly journals Dysregulation in Genital Tract Soluble Immune Mediators in Postmenopausal Women Is Distinct by HIV Status

2019 ◽  
Vol 35 (3) ◽  
pp. 251-259
Author(s):  
Mimi Ghosh ◽  
Mariel Jais ◽  
Josie Delisle ◽  
Naji Younes ◽  
Ifeyinwa Benyeogor ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Genital Tract ◽  
Hiv Status ◽  
Immune Mediators

Alterations in Genital Tract Soluble Immune Mediators in HIV Positive Postmenopausal Women: Implications for HIV Acquisition and Transmission

2014 ◽  
Vol 30 (S1) ◽  
pp. A231-A231
Author(s):  
Josie Delisle ◽  
Ifeyinwa Benyeogor ◽  
Mariel Jais ◽  
Naji Younes ◽  
Mary Young ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Genital Tract ◽  
Hiv Positive ◽  
Immune Mediators ◽  
Hiv Acquisition

scholarly journals Human papillomavirus infection rate, distribution characteristics, and risk of age in pre- and postmenopausal women

2020 ◽  
Author(s):  
Yan Shen ◽  
Jing Xia ◽  
Hui hui Li ◽  
Yang Xu ◽  
San ping Xu
Keyword(s):  
Cervical Cancer ◽  
High Risk ◽  
Postmenopausal Women ◽  
Infection Rate ◽  
Genital Tract ◽  
Hpv Infection ◽  
Distribution Characteristics ◽  
Lower Genital Tract ◽  
Significant Difference ◽  
High Risk Hpv

Abstract BackgroundThe incidence rate of cervical cancer is increasing yearly. The persistent infection of high-risk Human Papillomavirus (HPV) is the main factor leading to cervical cancer. HPV infection is double peak type. This study aimed at analyzing the HPV distribution characteristics, infection rate, and risk of age in pre- and postmenopausal women. So as to provide reference for the prevention of HPV infection and cervical cancer screening strategy.MethodsA retrospective analysis of 4614 women who underwent cervical cytology, and HPV examination from January 2018 to October 2019 at the healthcare department of Wuhan Union Hospital was done. We explored the characteristics and distribution of HPV infections around the menopause, then comparing the infection rate of HPV in postmenopause and over 65 years old, in order to analyze the influence of different ages on HPV infection.ResultsGenerally, the HPV infection rate was 13.10% (539 / 4115), whereby the high-risk subtype constituted 73.84% (398 / 539) of all positive cases. On the other hand, the HPV39 infection was more common in postmenopausal women; however, there was no significant difference in the distribution of the other types in the pre- and postmenopausal women (Insert p value). The first four subtypes were 52 / 53 / 58 / 16, respectively. The infection rate of HPV in patients with lower genital tract inflammation was significantly higher, P = 0.000, 95% CI: 1.911 (1.416, 2.580) compared with those without lower genital tract inflammation. The results further showed that there was no significant difference between pre- and postmenopausal women in terms of HPV infection rate, but more susceptible to high-risk HPV infection after the age of 65 (P = 0.041). Except for 40 years old to menopause, the infection rate of high-risk HPV in this age group was different from that in postmenopause(P = 0.023,0.729(0.555,0.957)), other age groups had no significant effect on high-risk HPV infection.ConclusionsIt was concluded that whether menopause has nothing to do with HPV infection. Moreover, the infection rate of high-risk HPV increases after 65 years of age; hence the cutoff screening age should be appropriately prolonged.Trial registration: Retrospectively registered.

scholarly journals Cross-Sectional Analysis of Selected Genital Tract Immunological Markers and Molecular Vaginal Microbiota in Sub-Saharan African Women, with Relevance to HIV Risk and Prevention

2015 ◽  
Vol 22 (5) ◽  
pp. 526-538 ◽  
Author(s):  
Jordan K. Kyongo ◽  
Tania Crucitti ◽  
Joris Menten ◽  
Liselotte Hardy ◽  
Piet Cools ◽  
...  
Keyword(s):  
Proinflammatory Cytokines ◽  
Genital Tract ◽  
Bacterial Species ◽  
Vaginal Microbiota ◽  
African Women ◽  
Sexually Active ◽  
Cross Sectional ◽  
Content Type ◽  
Immune Mediators ◽  
Sub Saharan

ABSTRACTData on immune mediators in the genital tract and the factors that modulate them in sub-Saharan women are limited. Cervicovaginal lavage (CVL) samples from 430 sexually active women from Kenya, South Africa, and Rwanda were analyzed for 12 soluble immune mediators using Bio-Plex and Meso Scale Discovery multiplex platforms, as well as single enzyme-linked immunosorbent assays. Ten bacterial species were quantified in vaginal swab samples. Bacterial vaginosis (BV) was defined by Nugent scoring. CVL samples from HIV-infected women showed a clear-cut proinflammatory profile. Pregnant women, adolescents, and women engaging in traditional vaginal practices differed in specific soluble markers compared to reference groups of adult HIV-negative women. Cervical mucus, cervical ectopy, abnormal vaginal discharge, and having multiple sex partners were each associated with an increase in inflammatory mediators. The levels of interleukin-1α (IL-1α), IL-1β, IL-6, IL-12(p70), and IL-8 were elevated, whereas the IL-1RA/IL-1(α+β) ratio decreased in women with BV. The level of gamma interferon-induced protein 10 was lower in BV-positive than in BV-negative women, suggesting its suppression as a potential immune evasion mechanism by BV-associated bacteria.Lactobacillus crispatusandLactobacillus vaginaliswere associated with decreased proinflammatory cytokines and each BV-associated species with increased proinflammatory cytokines. Remarkably, thein vitroanti-HIV activity of CVL samples from BV-positive women was stronger than that of BV-negative women. In conclusion, we found significant associations of factors, including vaginal microbiota, which can influence immune mediators in the vaginal environment in sexually active women. These factors need to be considered when establishing normative levels or pathogenic cutoffs of biomarkers of inflammation and associated risks in African women.

PRO 2000 elicits a decline in genital tract immune mediators without compromising intrinsic antimicrobial activity

AIDS ◽  
2007 ◽  
Vol 21 (4) ◽  
pp. 467-476 ◽  
Author(s):  
Marla J Keller ◽  
Esmeralda Guzman ◽  
Ehsan Hazrati ◽  
Andrea Kasowitz ◽  
Natalia Cheshenko ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Genital Tract ◽  
Immune Mediators

scholarly journals Verrucous Carcinoma of the Vulva: A Case Report

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Ioannis Boutas ◽  
Chrisostomos Sofoudis ◽  
Emmanouil Kalampokas ◽  
Christos Anastasopoulos ◽  
Theodoros Kalampokas ◽  
...  
Keyword(s):  
Case Report ◽  
Postmenopausal Women ◽  
Genital Tract ◽  
Verrucous Carcinoma ◽  
Female Genital Tract ◽  
University Hospital ◽  
Specialist Doctor ◽  
Rare Lesion ◽  
Female Genital

Verrucous carcinoma of the female genital tract is a rare lesion, primarily affecting postmenopausal women. We present a 78-year-old patient with verrucous carcinoma of the vulva, who was admitted to the “Aretaieion” Athens University Hospital. She had complained of vulvar itching during the last two years without visiting a specialist doctor.

Pyometra and estrous cycle modulate the uterine expression of the Kisspeptin system and angiogenic and immune factors in cats

2020 ◽  
Author(s):  
Luciano Cardoso Santos ◽  
Jeane Martinha Anjos Cordeiro ◽  
Larissa Silva Santana ◽  
Larissa Rodrigues Santana ◽  
Bianca Reis Santos ◽  
...  
Keyword(s):  
Estrous Cycle ◽  
Genital Tract ◽  
Functional Relationship ◽  
Female Genital Tract ◽  
Domestic Cat ◽  
Immune Mediators ◽  
Gene And Protein Expression ◽  
Gene Correlation

ABSTRACT Failures in hypothalamic kisspeptin/Kiss1r signaling are associated with infertility, and in vitro studies have shown that kisspeptin can modulate angiogenesis and immune activity. Because there is no in vivo research on the functional relationship between these factors in the reproductive system, especially in domestic cats, we evaluated the expression profile of kisspeptin/Kiss1r and angiogenic and immunological mediators in the genital tract of cyclic cats and of those with pyometra. The uterus of cats in diestrus exhibited greater gene and protein expression of Kiss1, as well as Vegf, Pigf, Mif, and Il6. In contrast, Kiss1r presented greater expression in proestrus/estrus, similarly to that observed for the immunostaining of INFγ, MIF, TNFα, and IL10. These factors were positively correlated with Kiss1 and/or Kiss1r, and a positive correlation between Kiss1 and Kiss1r was also observed in the uterus of cats during the estrous cycle. Cats with pyometra showed greater immunostaining of Kiss1 and Kiss1r on the endometrial surface and reduced immunostaining of Kiss1 in deep glands, whereas there was a significant reduction in Vegf, Pigf, Mif, and Il6 mRNA, and an increase in Tnf mRNA. The findings reveal that there is a gene correlation between kisspeptin/Kiss1r and angiogenic and immune mediators in the uterus of the domestic cat, which are modulated by the estrous cycle, and that pyometra affects the expression of these mediators. This study suggests, for the first time, a functional relationship between the Kiss/Kiss1r system and angiogenic and immune mediators in the female genital tract.

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