Identification of a Novel HIV-1 Recombinant Form (B/C) in Men Who Have Sex with Men in Shaanxi, China

2018 ◽  
Vol 34 (5) ◽  
pp. 467-470 ◽  
Author(s):  
Mengyan Zhang ◽  
Ruolei Xin ◽  
Wenhui Chang
Keyword(s):  
Recombinant Form ◽  
Sex With Men ◽  
Hiv 1

scholarly journals Identification and Characterization of a Novel HIV-1 Circulating Recombinant Form (CRF59_01B) Identified among Men-Who-Have-Sex-with-Men in China

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e99693 ◽  
Author(s):  
Weiqing Zhang ◽  
Xiaoxu Han ◽  
Minghui An ◽  
Bin Zhao ◽  
Qinghai Hu ◽  
...  
Keyword(s):  
Recombinant Form ◽  
Sex With Men ◽  
Identification And Characterization ◽  
Hiv 1

Identification of a Novel HIV-1 Unique Recombinant Form Between B, CRF01_AE and CRF07_BC in Men Who Have Sex with Men in Guangxi, China

2018 ◽  
Vol 34 (3) ◽  
pp. 319-323 ◽  
Author(s):  
Desheng Kong ◽  
Yan Wang ◽  
Chen Wang ◽  
Shujia Liang ◽  
Yi Feng ◽  
...  
Keyword(s):  
Recombinant Form ◽  
Unique Recombinant Form ◽  
Sex With Men ◽  
Hiv 1

Characterization of a Novel HIV-1 Second-Generation Recombinant Form in Men Who Have Sex with Men in Beijing, China

2017 ◽  
Vol 33 (11) ◽  
pp. 1175-1179 ◽  
Author(s):  
Chen Wang ◽  
Yan Wang ◽  
Desheng Kong ◽  
Ruolei Xin ◽  
Weisi Xu ◽  
...  
Keyword(s):  
Second Generation ◽  
Recombinant Form ◽  
Sex With Men ◽  
Beijing China ◽  
Hiv 1

Genetic characterization of a novel HIV-1 CRF01_AE/CRF07_BC recombinant form among men who have sex with men in Guangdong, China

2018 ◽  
Vol 163 (11) ◽  
pp. 3093-3097 ◽  
Author(s):  
Yun Lan ◽  
Wenchang Zhu ◽  
Fengyu Hu ◽  
Shixing Tang ◽  
Linghua Li ◽  
...  
Keyword(s):  
Genetic Characterization ◽  
Recombinant Form ◽  
Sex With Men ◽  
Hiv 1

scholarly journals Characterization of a novel HIV-1 second-generation circulating recombinant form (CRF102_0107) among men who have sex with men in Anhui, China

2019 ◽  
Vol 79 (6) ◽  
pp. 612-625 ◽  
Author(s):  
Xi Li ◽  
Jianjun Wu ◽  
Yu Zhang ◽  
Yuelan Shen ◽  
Hanping Li ◽  
...  
Keyword(s):  
Second Generation ◽  
Recombinant Form ◽  
Sex With Men ◽  
Hiv 1

Identification of a new HIV-1 BC circulating recombinant form (CRF60_BC) in Italian young men having sex with men

2014 ◽  
Vol 23 ◽  
pp. 176-181 ◽  
Author(s):  
Francesco Roberto Simonetti ◽  
Alessia Lai ◽  
Laura Monno ◽  
Francesca Binda ◽  
Gaetano Brindicci ◽  
...  
Keyword(s):  
Young Men ◽  
Recombinant Form ◽  
Sex With Men ◽  
Hiv 1

scholarly journals Cuban history of CRF19 recombinant subtype of HIV-1

2021 ◽  
Author(s):  
Anna Zhukova ◽  
Jakub Voznica ◽  
Miraine Dávila Felipe ◽  
Thu-Hien To ◽  
Lissette Pérez ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Temporal Analysis ◽  
Recombinant Form ◽  
Rapid Progression ◽  
Resistance Mutations ◽  
Data Set ◽  
Early Introduction ◽  
The World ◽  
Sex With Men ◽  
Hiv 1

AbstractCRF19 is a recombinant form of HIV-1 subtypes D, A1 and G, which was first sampled in Cuba in 1999, but was already present there in 1980s. CRF19 was reported almost uniquely in Cuba, where it accounts for ~25% of new HIV-positive patients and causes rapid progression to AIDS (~ 3 years).We analyzed a large data set comprising ~ 350 pol and env sequences sampled in Cuba over the last 15 years and ~ 350 from Los Alamos database. This data set contained both CRF19 (~ 315), and A1, D and G sequences. We performed and combined analyses for the three A1, G and D regions, using fast maximum likelihood approaches, including: (1) phylogeny reconstruction, (2) spatio-temporal analysis of the virus spread, and ancestral character reconstruction for (3) transmission mode and (4) drug resistance mutations (DRMs). This allowed us to acquire new insights on the CRF19 origin and transmission patterns. We showed that CRF19 recombined between 1966 and 1977, most likely in Cuban community stationed in Congo region. We further investigated CRF19 spread on the Cuban province level, and discovered that the epidemic started in 1970s, most probably in Villa Clara, that it was at first carried by heterosexual transmissions, and then quickly spread in the 1980s within the “men having sex with men” (MSM) community, with multiple transmissions back to heterosexuals. The analysis of the transmission patterns of common DRMs showed mostly acquired drug resistance rather than transmitted one.Our results show a very early introduction of CRF19 in Cuba, which could explain its local epidemiological success. Ignited by a major founder event, the epidemic then followed a similar pattern as other subtypes and CRFs in Cuba. The reason for the short time to AIDS remains to be understood and requires specific surveillance, in Cuba and elsewhere.Author summaryCRF19 is a recombinant form of HIV-1, which causes rapid progression to AIDS (~ 3 years versus 5 – 10 years for other subtypes and CRFs). CRF19 is reported almost uniquely in Cuba, where it is highly prevalent (~ 25%) among newly detected HIV-1 patients. In this study, we found that CRF19 most likely recombined around the 1970s in the Cuban community that was stationed in Democratic Republic of the Congo and Angola at that time. It was introduced very early into the Cuban province of Villa Clara, from where it had several introductions to La Habana in the 1980s and then further spread to other Cuban provinces. The CRF19 epidemic most probably started with heterosexual transmissions, followed in the 1980s by multiple introductions into “men having sex with men” (MSM) community, followed by multiple transmissions back to heterosexuals (often females). The early introduction of CRF19 into Cuba most likely explains its success, not observed in other parts of the world. However, importantly, its rapid progression to AIDS makes it crucial to survey CRF19 sub-epidemics not only in Cuba, but also in other parts of the world having regular exchanges with Cuba.

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