Molecular Genotyping of HIV-1 Strains from Newly Infected Men Who Have Sex with Men in Harbin, China

2016 ◽  
Vol 32 (6) ◽  
pp. 595-600 ◽  
Author(s):  
Qing-Hai Li ◽  
Fu-Xiang Wang ◽  
Chao Yue ◽  
Jia-Ye Wang ◽  
Gang Jin ◽  
...  
2020 ◽  
Vol 18 ◽  
Author(s):  
Yin Yueqi ◽  
Zhou Ying ◽  
Lu Jing ◽  
Guo Hongxiong ◽  
Chen Jianshuang ◽  
...  

Background: CRF01_AE and CRF07_BC are the two major HIV-1 virus strains circulating in China. The proportion of dominant subtypes (CRF01_AE and CRF07_BC) among MSM in Jiangsu province was over 80%. A large number of URFs have been found in China in recently years. Objective: This study aimed to report on novel HIV-1 recombinants. Method: We constructed Phylogenetic trees using the maximum likelihood (ML) method with 1000 bootstrap replicates in IQ-TREE 1.6.8 software and determined recombination break points using SimPlot 3.5.1. Results: We identified a novel, second-generation HIV-1 recombinant (JS020202) between CRF01_AE and CRF07_BC. The analysis of near full-length genome (NFLG) showed there were at least 8 breakpoints inner virus, which differed from any previously identified CRF and URF around the world. Conclusion: Novel diverse CRF01_AE/07_BC suggested the complexity trends of HIV-1 genetics. The emergency situation of diverse recombinant strains should be monitored continuously.


2019 ◽  
Vol 14 (12) ◽  
pp. 791-798
Author(s):  
Ivailo Alexiev ◽  
Elitsa Golkocheva-Markova ◽  
Asya Kostadinova ◽  
Reneta Dimitrova ◽  
Lora Nikolova ◽  
...  

Aim: To evaluate hepatitis B virus (HBV) and hepatitis C virus (HCV) among individuals with HIV/AIDS in Bulgaria diagnosed between 2010 and 2015. Materials & methods: A total of 1158 individuals were diagnosed with HIV/AIDS during the study period. Different transmission groups were tested with ELISA and real-time PCR for HBV and HCV markers. Results: Hepatitis B surface antigen and hepatitis C virus antiboby were found in 9.3 and 23.2% of the tested. HBV DNA and HCV RNA has been found in 47.4 and 69.6%. Hepatitis B and C co-infections were predominant in multiple risk behavior groups, including people who inject drugs, men who have sex with men, prisoners and Roma individuals. Conclusion: HIV prevalence in Bulgaria is low but the rates of hepatitis B and C co-infections among these patients fall within the upper range reported in Europe.


2014 ◽  
Vol 59 (6) ◽  
pp. 910-911 ◽  
Author(s):  
K. T. Ng ◽  
K. Y. Ng ◽  
J. H.-K. Chen ◽  
O. T. Ng ◽  
A. Kamarulzaman ◽  
...  

2015 ◽  
Vol 2 (2) ◽  
pp. e64-e70 ◽  
Author(s):  
Frits van Griensven ◽  
Timothy H Holtz ◽  
Warunee Thienkrua ◽  
Wannee Chonwattana ◽  
Wipas Wimonsate ◽  
...  

2011 ◽  
Vol 48 (1) ◽  
pp. 94-99 ◽  
Author(s):  
Lisa B. Hightow-Weidman ◽  
Christopher B. Hurt ◽  
Gregory Phillips ◽  
Karen Jones ◽  
Manya Magnus ◽  
...  

This chapter provides background information to the events that led to the discovery of HIV. Previously fit young men who have sex with men presented with certain infections and cancers, coupled with severe immune deficiency, which was later given the name acquired immune deficiency syndrome (AIDS). This chapter gives information about the origin of HIV and its link to simian immunodeficiency viruses (SIVs). This chapter provides information on the geographical, and the epidemiological differences between HIV-1 and HIV-2. The chapter also explains the biological implications of HIV types and subtypes. Risk factors and transmission routes are also discussed, in addition to UK and worldwide HIV prevalence data.


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