scholarly journals HIV-1 Transmission Networks Among Men Who Have Sex With Men in Asia

2014 ◽  
Vol 59 (6) ◽  
pp. 910-911 ◽  
Author(s):  
K. T. Ng ◽  
K. Y. Ng ◽  
J. H.-K. Chen ◽  
O. T. Ng ◽  
A. Kamarulzaman ◽  
...  
Keyword(s):  
Transmission Networks ◽  
Sex With Men ◽  
Hiv 1

Transmission networks of HIV-1 among men having sex with men in the Netherlands

AIDS ◽  
2010 ◽  
Vol 24 (2) ◽  
pp. 271-282 ◽  
Author(s):  
Daniela Bezemer ◽  
Ard van Sighem ◽  
Vladimir V Lukashov ◽  
Lia van der Hoek ◽  
Nicole Back ◽  
...  
Keyword(s):  
The Netherlands ◽  
Transmission Networks ◽  
Sex With Men ◽  
Hiv 1

scholarly journals HIV-1 Infection and Transmission Networks of Younger People in Chicago, Illinois, 2005-2011

2016 ◽  
Vol 132 (1) ◽  
pp. 48-55 ◽  
Author(s):  
Ethan Morgan ◽  
Alexandra M. Oster ◽  
Stephanie Townsell ◽  
Donna Peace ◽  
Nanette Benbow ◽  
...  
Keyword(s):  
Hiv Transmission ◽  
Black People ◽  
Multivariable Analysis ◽  
Transmission Networks ◽  
Metropolitan Regions ◽  
Infected People ◽  
Sex With Men ◽  
High Level ◽  
High Degree ◽  
Hiv 1

Objective: Analysis of HIV nucleotide sequences can be used to identify people with highly similar HIV strains and understand transmission patterns. The objective of this study was to identify groups of people highly connected by HIV transmission and the extent to which transmission occurred within and between geographic areas in Chicago, Illinois. Methods: We analyzed genetic sequences in the HIV-1 pol region in samples collected from people participating in the VARHS program in Chicago during 2005-2011. We determined pairwise genetic distance, inferred potential transmission events between HIV-infected people whose sequences were ≤1.5% genetically distant, and identified clusters of connected people. We used multivariable analysis to determine demographic characteristics and risk attributes associated with degree of connectivity. Results: Of 1154 sequences, 177 (15.3%) were tied to at least 1 other sequence. We determined that younger people, men, non-Hispanic black people, and men who have sex with men were more highly connected than other HIV-infected people. We also identified a high degree of geographic heterogeneity—48 of 67 clusters (71.6%) contained people from >1 Chicago region (north, south, or west sides). Conclusion: Our results indicate a need to address HIV transmission through the networks of younger non-Hispanic black men who have sex with men. The high level of geographic heterogeneity observed suggests that HIV prevention programs should be targeted toward networks of younger people rather than geographic areas of high incidence. This study could also guide prevention efforts in other diverse metropolitan regions with characteristics similar to those of Chicago.

Genetic transmission networks reveal the transmission patterns of HIV-1 CRF01_AE in China

2017 ◽  
Vol 94 (2) ◽  
pp. 111-116 ◽  
Author(s):  
Xiaoshan Li ◽  
Rong Gao ◽  
Kexin Zhu ◽  
Feiran Wei ◽  
Kun Fang ◽  
...  
Keyword(s):  
Hiv Transmission ◽  
Risk Groups ◽  
Public Health Issue ◽  
Transmission Networks ◽  
Major Public Health Issue ◽  
Genetic Transmission ◽  
Heterosexual Women ◽  
Sex With Men ◽  
Migrant People ◽  
Hiv 1

ObjectivesThe epidemic of HIV-1 CRF01_AE has become a major public health issue in China. This study aimed to characterise the transmission patterns of genetic networks for CRF01_AE nationwide and elucidate possible opportunities for prevention.MethodsWe isolated and conducted genetic transmission network analysis of all available CRF01_AE pol sequences (n=4704) from China in the Los Alamos HIV sequence database.ResultsA total of 1391 (29.6%) sequences were identified as belonging to 400 separate networks. Of men who have sex with men (MSM) in the networks, 93.8% were linked to other MSM and only 2.4% were linked to heterosexual women. However, 11.8% heterosexual women in the networks were linked to MSM. Lineages composed mainly of MSM had higher transmission than those that were mostly heterosexuals. Of the 1391 individuals in networks, 513 (36.9%) were linked to cases diagnosed in different provinces. The proportion of individuals involved in inter-province links was interrelated with the number of migrant people (Spearman’s r=0.738, p=0.001).ConclusionsThe outcome of this study could help improve our ability to understand HIV transmission among various regions and risk groups in China, and highlighted the importance of targeting MSM and migrants by prevention and intervention efforts.

scholarly journals Expanding HIV-1 subtype B transmission networks among men who have sex with men in Poland

PLoS ONE ◽  
2017 ◽  
Vol 12 (2) ◽  
pp. e0172473 ◽  
Author(s):  
Miłosz Parczewski ◽  
Magdalena Leszczyszyn-Pynka ◽  
Magdalena Witak-Jędra ◽  
Bartosz Szetela ◽  
Jacek Gąsiorowski ◽  
...  
Keyword(s):  
Transmission Networks ◽  
Subtype B ◽  
Sex With Men ◽  
Hiv 1

Genetic diversity and transmission networks of HIV-1 strains among men having sex with men (MSM) in Lomé, Togo

2016 ◽  
Vol 46 ◽  
pp. 279-285 ◽  
Author(s):  
Abla A. Konou ◽  
Nicole Vidal ◽  
Mounerou Salou ◽  
Simplice Anato ◽  
Assetina Singo-Tokofaï ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Transmission Networks ◽  
Sex With Men ◽  
Hiv 1

scholarly journals The Central Role of Nondisclosed Men Who Have Sex With Men in Human Immunodeficiency Virus-1 Transmission Networks in Guangzhou, China

2020 ◽  
Vol 7 (5) ◽  
Author(s):  
Huanchang Yan ◽  
Weiyun He ◽  
Liping Huang ◽  
Hao Wu ◽  
Yuanhao Liang ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Hiv Transmission ◽  
Central Position ◽  
Sex Behavior ◽  
Transmission Networks ◽  
Immunodeficiency Virus ◽  
Sex With Men ◽  
Centrality Analysis ◽  
Hiv 1

Abstract Background Men who have sex with men (MSM) are vulnerable risk group for human immunodeficiency virus (HIV)-1 infection. However, some MSM do not disclose their same-sex behavior and could impact the transmission and prevention of HIV-1 infection. Here, we evaluated the role of nondisclosed MSM in HIV-1 transmission in Guangzhou, China. Methods The HIV-1 pol sequences were obtained from HIV-infected subjects from 2008 to 2015. A transmission network was constructed using HIV TRAnsmission Cluster Engine (HIV-TRACE) at a pairwise genetic distance of 0.5%. The position of nondisclosed MSM in the network was determined by centrality analysis. Results Nondisclosed MSM were inferred in 9.92% (61 of 615) of slightly older, self-reported non-MSM (P = .006). They were more likely to be married (P = .002) and less educated (P < .001) than the MSM with whom they clustered. Closeness centrality was bigger for nondisclosed MSM than for MSM (P < .001), indicating the central position of nondisclosed MSM in the networks. The average shortest path length was smaller for nondisclosed MSM than for MSM (P < .001), whereas radiality was bigger for nondisclosed MSM than for MSM, suggesting a relatively greater contribution of nondisclosed MSM in transmitting HIV-1 than MSM. Assortativity analysis indicated that nondisclosed MSM were more likely to link each other with coefficient of 0.025. Conclusions Nondisclosed MSM are a specific group, and they play an important role in HIV-1 transmission. They could be bisexual and might increase the risk of HIV-1 infection to their sex partners. Therefore, specific prevention and intervention targeting nondisclosed MSM are urgently needed.

scholarly journals Shared HCV Transmission Networks Among HIV-1–Positive and HIV-1–Negative Men Having Sex With Men by Ultradeep Sequencing

2019 ◽  
Vol 82 (1) ◽  
pp. 105-110 ◽  
Author(s):  
Thuy Nguyen ◽  
Constance Delaugerre ◽  
Marc-Antoine Valantin ◽  
Corinne Amiel ◽  
Emmanuelle Netzer ◽  
...  
Keyword(s):  
Transmission Networks ◽  
Hcv Transmission ◽  
Sex With Men ◽  
Hiv 1

scholarly journals First Detection of a Cluster Novel HIV-1 Second-Generation Recombinant (CRF01_AE/CRF07_BC) among Men Who Have Sex with Men in Nanjing, Eastern China

Intervirology ◽  
2021 ◽  
Vol 64 (2) ◽  
pp. 81-87 ◽  
Author(s):  
Yueqi Yin ◽  
Ying Zhou ◽  
Jing Lu ◽  
Hongxiong Guo ◽  
Jianshuang Chen ◽  
...  
Keyword(s):  
Phylogenetic Trees ◽  
Second Generation ◽  
Eastern China ◽  
Northern China ◽  
Small Scale ◽  
Transmission Networks ◽  
Nanjing City ◽  
Sex With Men ◽  
Full Length Genome ◽  
Hiv 1

<b><i>Introduction:</i></b> A large number of unique recombinant forms have been found in China in recent years. This study aimed to report on a cluster of novel HIV-1 recombinants. <b><i>Methods:</i></b> We constructed phylogenetic trees using the maximum likelihood (ML) method with 1,000 bootstrap replicates in IQ-TREE 1.6.8 software and determined recombination break points using SimPlot 3.5.1. <b><i>Results:</i></b> Overall, 9 near-full-length genome (NFLG) sequences were reported in this study, including 1 circulation recombinant form (CRF)01_AE NFLG sequence and 8 highly similar novel HIV-1 second-generation recombinants composed of CRF01_AE and CRF07_BC (CRF105_0107) isolated from a cluster HIV-positive male subjects infected among men who have sex with men (MSM) in Nanjing, eastern China. The phylogenetic analysis of NFLG showed 1 sequence named “nj16” to have at least 11 breakpoints inner virus and 7 other sequences to have at least 10 breakpoints inner virus. Our findings further showed as follows: first, this is the first time that a cluster of novel CRF105_0107 HIV-1 strains were identified among MSM in Nanjing, Jiangsu. Second, the Chinese “4a” cluster of CRF01_AE which mainly circulating in northern China has spread in Jiangsu for more than 15 years. Third, HIV-1 recombination events were active in Nanjing city, and novel recombinants could spread rapidly through some small-scale transmission networks. <b><i>Conclusion:</i></b> The continued emergence of novel recombinant HIV-1 strains in Nanjing suggests dynamics and complexity in the HIV epidemic among MSM in Jiangsu province. Further investigations and molecular epidemiological research should be taken to monitor and understand transmission networks among MSM.

scholarly journals Characterisation of HIV-1 transmission clusters and drug-resistant mutations in Denmark, 2004 to 2016

2018 ◽  
Vol 23 (44) ◽  
Author(s):  
Andreas Petersen ◽  
Susan A Cowan ◽  
Jens Nielsen ◽  
Thea K Fischer ◽  
Jannik Fonager
Keyword(s):  
Drug Resistance ◽  
Drug Resistant ◽  
Resistance Mutations ◽  
Transmission Networks ◽  
Late Presenters ◽  
Drug Resistance Mutations ◽  
Hiv Epidemic ◽  
Immunodeficiency Virus ◽  
Sex With Men ◽  
Hiv 1

This study describes the prevalence of human immunodeficiency virus (HIV) drug resistance mutations among 1,815 patients in Denmark from 2004 to 2016 and characterises transmission clusters. POL sequences were analysed for subtype, drug resistance mutations and phylogenetic relationship. The prevalence of surveillance drug resistance mutations (SDRM) was 6.7%, while the prevalence of drug resistance mutations (DRM) with a clinical impact was 12.3%. We identified 197 transmission clusters with 706 patients. Patients 40 years or older were less likely to be members of a transmission cluster and patients in transmission clusters were less likely to be infected abroad. The proportion of late presenters (LP) was lower in active compared with inactive clusters. Large active clusters consisted of more men who have sex with men (MSM), had members more frequently infected in Denmark and contained a significantly lower proportion of LP and significantly fewer patients with DRM than small active clusters. Subtyping demonstrated that the Danish HIV epidemic is gradually becoming more composed of non-B subtypes/circulating recombinant forms. This study shows that active HIV-1 transmission has become increasingly MSM-dominated and that the recent increase in SDRM and DRM prevalence is not associated with more sustained transmission within identified transmission networks or clusters.

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