Effect of HIV Type 1 Subtype on Virological and Immunological Response to Combination Antiretroviral Therapy: Evidence for a More Rapid Viral Suppression for Subtype A Than Subtype B-Infected Greek Individuals

2013 ◽  
Vol 29 (3) ◽  
pp. 461-469 ◽  
Author(s):  
Dimirios Paraskevis ◽  
Giota Touloumi ◽  
Giorgos Bakoyannis ◽  
Vassilios Paparizos ◽  
Marios Lazanas ◽  
...  
2010 ◽  
Vol 15 (6) ◽  
pp. 871-879 ◽  
Author(s):  
Anouk M Kesselring ◽  
Luuk Gras ◽  
Ferdinand W Wit ◽  
Colette Smit ◽  
Suzanne E Geerlings ◽  
...  

2005 ◽  
Vol 40 (4) ◽  
pp. 604-608 ◽  
Author(s):  
P. L. A. Fraaij ◽  
G. Verweel ◽  
A. M. C. van Rossum ◽  
E. G. van Lochem ◽  
M. Schutten ◽  
...  

1998 ◽  
Vol 14 (8) ◽  
pp. 669-676 ◽  
Author(s):  
ALEKSEI BOBKOV ◽  
ELENA KAZENNOVA ◽  
LUDMILA SELIMOVA ◽  
MARINA BOBKOVA ◽  
TATYANA KHANINA ◽  
...  

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
S. Sinha ◽  
H. Ahmad ◽  
R. C. Shekhar ◽  
N. Kumar ◽  
L. Dar ◽  
...  

Objective. The increased use of antiretroviral therapy (ART) has reduced the morbidity and mortality associated with HIV, adversely leading to the emergence of HIV drug resistance (HIVDR). In this study we aim to evaluate the prevalence of HIVDR mutations in ART-naive HIV-1 infected patients from northern India.Design. Analysis was performed using Viroseq genotyping system based on sequencing of entire protease and two-thirds of the Reverse Transcriptase (RT) region ofpolgene.Results. Seventy three chronic HIV-1 infected ART naïve patients eligible for first line ART were enrolled from April 2006 to August 2008. In 68 patients DNA was successfully amplified and sequencing was done. 97% of HIV-1 strains belonged to subtype C, and one each to subtype A1 and subtype B. The overall prevalence of primary DRMs was 2.9% [2/68, 95% confidence interval (CI), 0.3%–10.2%]. One patient had a major RT mutation M184V, known to confer resistance to lamivudine, and another had a major protease inhibitor (PI) mutation D30N that imparts resistance to nelfinavir.Conclusion. Our study shows that primary HIVDR mutations have a prevalence of 2.9% among ART-naive chronic HIV-1 infected individuals.


2005 ◽  
Vol 21 (9) ◽  
pp. 830-833 ◽  
Author(s):  
Natallia V. Lazouskaya ◽  
Vladimir F. Eremin ◽  
Karen W. Adema ◽  
Elena L. Gasich ◽  
Elly Baan ◽  
...  

1999 ◽  
Vol 15 (1) ◽  
pp. 3-9 ◽  
Author(s):  
Dennis L. Ellenberger ◽  
Danuta Pieniazek ◽  
John Nkengasong ◽  
Chi-Cheng Luo ◽  
Sushil Devare ◽  
...  

2004 ◽  
Vol 39 (4) ◽  
pp. 575-578 ◽  
Author(s):  
O. Akinsete ◽  
D. Hirigoyen ◽  
C. Cartwright ◽  
R. Schut ◽  
R. Kantor ◽  
...  

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