The High Frequency of HIV Type 1-Specific Cellular Immune Responses in Seronegative Individuals with Parenteral and/or Heterosexual HIV Type 1 Exposure

2012 ◽  
Vol 28 (12) ◽  
pp. 1598-1605 ◽  
Author(s):  
Boris V. Murashev ◽  
Olga V. Nazarenko ◽  
Ekaterina B. Akulova ◽  
Anna K. Artemyeva ◽  
Sergey V. Verevochkin ◽  
...  
Keyword(s):  
Immune Responses ◽  
High Frequency ◽  
Cellular Immune Responses ◽  
Hiv Type 1 ◽  
Cellular Immune

Short Communication Antibody and Cellular Immune Responses in Breakthrough Infection Subjects after HIV Type 1 Glycoprotein 120 Vaccination

1999 ◽  
Vol 15 (18) ◽  
pp. 1685-1689 ◽  
Author(s):  
Christopher P. Locher ◽  
Robert M. Grant ◽  
Eric A. Collisson ◽  
Gustavo Reyes-Teran ◽  
Tarek Elbeik ◽  
...  
Keyword(s):  
Immune Responses ◽  
Short Communication ◽  
Breakthrough Infection ◽  
Cellular Immune Responses ◽  
Hiv Type 1 ◽  
Cellular Immune

scholarly journals No Differences in Cellular Immune Responses between Asymptomatic HIV Type 1– and Type 2–Infected Gambian Patients

2004 ◽  
Vol 189 (3) ◽  
pp. 498-505 ◽  
Author(s):  
Assan Jaye ◽  
Ramu Sarge‐Njie ◽  
Maarten Schim van der Loeff ◽  
Jim Todd ◽  
Abraham Alabi ◽  
...  
Keyword(s):  
Immune Responses ◽  
Cellular Immune Responses ◽  
Hiv Type 1 ◽  
Cellular Immune ◽  
Asymptomatic Hiv

HIV Type 1-Specific Inter- and Intrasubtype Cellular Immune Responses in HIV Type 1-Infected Ugandans

2004 ◽  
Vol 20 (7) ◽  
pp. 763-771 ◽  
Author(s):  
Alleluiah Rutebemberwa ◽  
Betty Auma ◽  
Jill Gilmour ◽  
Gareth Jones ◽  
David Yirrell ◽  
...  
Keyword(s):  
Immune Responses ◽  
Cellular Immune Responses ◽  
Hiv Type 1 ◽  
Cellular Immune

Evaluation of Cellular Immune Responses in Subjects Chronically Infected with HIV Type 1

2007 ◽  
Vol 23 (1) ◽  
pp. 67-76 ◽  
Author(s):  
Tong-Ming Fu ◽  
Sheri A. Dubey ◽  
Devan V. Mehrotra ◽  
Daniel C. Freed ◽  
Wendy L. Trigona ◽  
...  
Keyword(s):  
Immune Responses ◽  
Cellular Immune Responses ◽  
Hiv Type 1 ◽  
Cellular Immune

scholarly journals Cellular Immune Responses of Schistosomiasis Patients Are Altered by Human Immunodeficiency Virus Type 1 Coinfection

2001 ◽  
Vol 184 (4) ◽  
pp. 488-496 ◽  
Author(s):  
Pauline N. M. Mwinzi ◽  
Diana M. S. Karanja ◽  
Daniel G. Colley ◽  
Alloys S. S. Orago ◽  
W. Evan Secor
Keyword(s):  
Human Immunodeficiency Virus ◽  
Immune Responses ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Cellular Immune Responses ◽  
Immunodeficiency Virus ◽  
Cellular Immune

scholarly journals Human Immunodeficiency Virus Type 1-Hepatitis C Virus Coinfection: Intraindividual Comparison of Cellular Immune Responses against Two Persistent Viruses

2002 ◽  
Vol 76 (6) ◽  
pp. 2817-2826 ◽  
Author(s):  
Georg M. Lauer ◽  
Tam N. Nguyen ◽  
Cheryl L. Day ◽  
Gregory K. Robbins ◽  
Theresa Flynn ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Immune Responses ◽  
T Lymphocyte ◽  
Viral Loads ◽  
Cellular Immune Responses ◽  
Immunodeficiency Virus ◽  
Cellular Immune ◽  
Lymphocyte Responses ◽  
Hiv 1

ABSTRACT Both human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) lead to chronic infection in a high percentage of persons, and an expanding epidemic of HIV-1-HCV coinfection has recently been identified. These individuals provide an opportunity for simultaneous assessment of immune responses to two viral infections associated with chronic plasma viremia. In this study we analyzed the breadth and magnitude of the CD8+- and CD4+-T-lymphocyte responses in 22 individuals infected with both HIV-1 and HCV. A CD8+-T-lymphocyte response against HIV-1 was readily detected in all subjects over a broad range of viral loads. In marked contrast, HCV-specific CD8+-T-lymphocyte responses were rarely detected, despite viral loads in plasma that were on average 1,000-fold higher. The few HCV-specific responses that were observed were relatively weak and limited in breadth. CD4-proliferative responses against HIV-1 were detected in about half of the coinfected subjects tested, but no proliferative response against any HCV protein was found in these coinfected persons. These data demonstrate a major discordance in immune responses to two persistent RNA viruses. In addition, they show a consistent and profound impairment in cellular immune responses to HCV compared to HIV-1 in HIV-1-HCV-coinfected persons.

Humoral and cellular immune responses to proinsulin in adults with newly diagnosed type 1 diabetes

2003 ◽  
Vol 19 (1) ◽  
pp. 52-59 ◽  
Author(s):  
Parth Narendran ◽  
Alistair J. Williams ◽  
Kathryn Elsegood ◽  
Nicola J. Leech ◽  
Colin M. Dayan
Keyword(s):  
Type 1 Diabetes ◽  
Immune Responses ◽  
Newly Diagnosed ◽  
Cellular Immune Responses ◽  
Cellular Immune

scholarly journals Enhancement of Primary and Secondary Cellular Immune Responses against Human Immunodeficiency Virus Type 1 Gag by Using DNA Expression Vectors That Target Gag Antigen to the Secretory Pathway

2000 ◽  
Vol 74 (13) ◽  
pp. 5997-6005 ◽  
Author(s):  
Jian-Tai Qiu ◽  
Bindong Liu ◽  
Chunjuan Tian ◽  
George N. Pavlakis ◽  
Xiao-Fang Yu
Keyword(s):  
Human Immunodeficiency Virus ◽  
Immune Responses ◽  
Human Immunodeficiency Virus Type ◽  
Expression Vectors ◽  
Cellular Immune Responses ◽  
Immunodeficiency Virus ◽  
Dna Vector ◽  
Cellular Immune ◽  
Hiv 1

ABSTRACT In this study, we have investigated the influence of antigen targeting after DNA vaccination upon the induction of cellular immune responses against human immunodeficiency virus type 1 (HIV-1) Gag. In addition to the standard version of HIV-1 Gag, we constructed Gag expression vectors that encode a secreted (Sc-Gag) and a cytoplasmic (Cy-Gag) Gag molecule. Although all three HIV-1 Gag expression vectors induced detectable humoral and cellular immune responses, after intramuscular injection the DNA vector encoding the Sc-Gag generated the highest primary cytotoxic T-lymphocyte (CTL) and T-helper responses. Mice immunized with one of the HIV-1 Gag DNA vectors (but not with the control vector pcDNA3.1) developed a protective immune response against infection with recombinant vaccinia virus expressing HIV-1 Gag, and this response persisted for 125 days. The magnitude of the protection correlated with the levels of Gag-specific ex vivo CTL activity and the number of CD8+ T cells producing gamma interferon. The DNA vector encoding the Sc-Gag induced higher levels of protection and greater secondary CTL responses than did the DNA vector encoding Cy-Gag.

scholarly journals Cellular Immune Responses against Simian T-Lymphotropic Virus Type 1 Target Tax in Infected Baboons

2016 ◽  
Vol 90 (11) ◽  
pp. 5280-5291 ◽  
Author(s):  
Iris Castro ◽  
Teresa M. Giret ◽  
Diogo M. Magnani ◽  
Helen S. Maxwell ◽  
Oliver Umland ◽  
...  
Keyword(s):  
Immune Responses ◽  
Virus Type ◽  
T Cell Response ◽  
Content Type ◽  
T Lymphotropic Virus ◽  
Cellular Immune Responses ◽  
Tax Protein ◽  
Baboon Model ◽  
Cellular Immune

ABSTRACTThere are currently 5 million to 10 million human T-lymphotropic virus type 1 (HTLV-1)-infected people, and many of them will develop severe complications resulting from this infection. A vaccine is urgently needed in areas where HTLV-1 is endemic. Many vaccines are best tested in nonhuman primate animal models. As a first step in designing an effective HTLV-1 vaccine, we defined the CD8+and CD4+T cell response against simian T-lymphotropic virus type 1 (STLV-1), a virus closely related to HTLV-1, in olive baboons (Papioanubis). Consistent with persistent antigenic exposure, we observed that STLV-1-specific CD8+T cells displayed an effector memory phenotype and usually expressed CD107a, gamma interferon (IFN-γ), and tumor necrosis factor alpha (TNF-α). To assess the viral targets of the cellular immune response in STLV-1-infected animals, we used intracellular cytokine staining to detect responses against overlapping peptides covering the entire STLV-1 proteome. Our results show that, similarly to humans, the baboon CD8+T cell response narrowly targeted the Tax protein. Our findings suggest that the STLV-1-infected baboon model may recapitulate some of the important aspects of the human response against HTLV-1 and could be an important tool for the development of immune-based therapy and prophylaxis.IMPORTANCEHTLV-1 infection can lead to many different and often fatal conditions. A vaccine deployed in areas of high prevalence might reduce the incidence of HTLV-1-induced disease. Unfortunately, there are very few animal models of HTLV-1 infection useful for testing vaccine approaches. Here we describe cellular immune responses in baboons against a closely related virus, STLV-1. We show for the first time that the immune response against STLV-1 in naturally infected baboons is largely directed against the Tax protein. Similar findings in humans and the sequence similarity between the human and baboon viruses suggest that the STLV-1-infected baboon model might be useful for developing a vaccine against HTLV-1.

Sign in / Sign up

Export Citation Format

Share Document