scholarly journals Short Communication: Antiretroviral Therapy Resistance Mutations Present in the HIV Type 1 Subtype C pol and env Regions from Therapy-Naive Patients in Zambia

2010 ◽  
Vol 26 (7) ◽  
pp. 795-803 ◽  
Author(s):  
Sandra Gonzalez ◽  
Clement Gondwe ◽  
Damien C. Tully ◽  
Veenu Minhas ◽  
Danielle Shea ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Short Communication ◽  
Therapy Resistance ◽  
Resistance Mutations ◽  
Subtype C ◽  
Hiv Type 1

scholarly journals Prevalence of HIV Drug Resistance Mutations in HIV Type 1 Isolates in Antiretroviral Therapy Naïve Population from Northern India

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
S. Sinha ◽  
H. Ahmad ◽  
R. C. Shekhar ◽  
N. Kumar ◽  
L. Dar ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Antiretroviral Therapy ◽  
Resistance Mutations ◽  
Subtype C ◽  
Hiv Drug Resistance ◽  
Northern India ◽  
Subtype B ◽  
Hiv Type 1 ◽  
Hiv 1

Objective. The increased use of antiretroviral therapy (ART) has reduced the morbidity and mortality associated with HIV, adversely leading to the emergence of HIV drug resistance (HIVDR). In this study we aim to evaluate the prevalence of HIVDR mutations in ART-naive HIV-1 infected patients from northern India.Design. Analysis was performed using Viroseq genotyping system based on sequencing of entire protease and two-thirds of the Reverse Transcriptase (RT) region ofpolgene.Results. Seventy three chronic HIV-1 infected ART naïve patients eligible for first line ART were enrolled from April 2006 to August 2008. In 68 patients DNA was successfully amplified and sequencing was done. 97% of HIV-1 strains belonged to subtype C, and one each to subtype A1 and subtype B. The overall prevalence of primary DRMs was 2.9% [2/68, 95% confidence interval (CI), 0.3%–10.2%]. One patient had a major RT mutation M184V, known to confer resistance to lamivudine, and another had a major protease inhibitor (PI) mutation D30N that imparts resistance to nelfinavir.Conclusion. Our study shows that primary HIVDR mutations have a prevalence of 2.9% among ART-naive chronic HIV-1 infected individuals.

Short Communication: Non-B HIV Type 1 Subtypes: Replicative Capacity and Response to Antiretroviral Therapy

2004 ◽  
Vol 20 (8) ◽  
pp. 816-818 ◽  
Author(s):  
Emanuele Nicastri ◽  
Loredana Sarmati ◽  
Gabriella D'Ettorre ◽  
Saverio G. Parisi ◽  
Lucia Palmisano ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Short Communication ◽  
Replicative Capacity ◽  
Hiv Type 1

scholarly journals Short Communication: Characterization of Drug-Resistance Mutations in HIV Type 1 Isolates from Drug-Naive and ARV-Treated Patients in Bulgaria

2008 ◽  
Vol 24 (9) ◽  
pp. 1133-1138 ◽  
Author(s):  
Maria Mercedes Santoro ◽  
Massimo Ciccozzi ◽  
Claudia Alteri ◽  
Stefania Montieri ◽  
Ivailo Alexiev ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Short Communication ◽  
Resistance Mutations ◽  
Drug Resistance Mutations ◽  
Drug Naïve ◽  
Hiv Type 1

scholarly journals Drug Resistance Mutations in HIV Type 1 Isolates from Patients Failing Antiretroviral Therapy in Morocco

2012 ◽  
Vol 28 (8) ◽  
pp. 944-948 ◽  
Author(s):  
Hicham El Annaz ◽  
Patricia Recordon-Pinson ◽  
Rida Tagajdid ◽  
Toufik Doblali ◽  
Bouchra Belefquih ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Antiretroviral Therapy ◽  
Resistance Mutations ◽  
Drug Resistance Mutations ◽  
Hiv Type 1
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