Genotypic and Phenotypic Analyses of Human Immunodeficiency Virus Type 1 in Antiretroviral Drug-Naive Nigerian Patients

2006 ◽  
Vol 22 (1) ◽  
pp. 22-26 ◽  
Author(s):  
Simon M. Agwale ◽  
Clement Zeh ◽  
Ellen Paxinos ◽  
Lilian Odama ◽  
Danuta Pienazek ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Antiretroviral Drug ◽  
Immunodeficiency Virus ◽  
Drug Naïve

scholarly journals Dynamics of Human Immunodeficiency Virus Type 1 Replication in Vertically Infected Infants

1999 ◽  
Vol 73 (1) ◽  
pp. 362-367 ◽  
Author(s):  
Katherine Luzuriaga ◽  
Hulin Wu ◽  
Margaret McManus ◽  
Paula Britto ◽  
William Borkowsky ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Drug Regimen ◽  
Turnover Rates ◽  
Antiretroviral Drug ◽  
Immunodeficiency Virus ◽  
Hiv 1

ABSTRACT Plasma human immunodeficiency virus type 1 (HIV-1) turnover and kinetics were studied in children aged 15 days to 2 years following the initiation of a triple antiretroviral drug regimen consisting of zidovudine, lamivudine, and nevirapine. HIV-1 turnover was at least as rapid as that previously described in adults; turnover rates were more rapid in infants and children aged 3 months to 2 years than in infants less than 3 months of age. These data confirm the central role of HIV-1 replication in the pathogenesis of vertical HIV-1 infection and reinforce the importance of early, potent combination therapies for the long-term control of HIV-1 replication.

scholarly journals Three-Class-Resistant Human Immunodeficiency Virus Type 1 Variant in a Drug-Naive Heterosexual Couple

2008 ◽  
Vol 46 (11) ◽  
pp. 3856-3859 ◽  
Author(s):  
F. Razzolini ◽  
F. Saladini ◽  
L. Malincarne ◽  
I. Vicenti ◽  
N. Palladino ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Heterosexual Couple ◽  
Immunodeficiency Virus ◽  
Drug Naïve

scholarly journals Antiretroviral Drug Therapy Alters the Profile of Human Immunodeficiency Virus Type 1-Specific T-Cell Responses and Shifts the Immunodominant Cytotoxic T-Lymphocyte Response from Gag to Pol

2007 ◽  
Vol 81 (20) ◽  
pp. 11543-11548 ◽  
Author(s):  
A. C. Karlsson ◽  
J. M. Chapman ◽  
B. D. Heiken ◽  
R. Hoh ◽  
E. G. Kallas ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Drug Therapy ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Cytotoxic T Lymphocyte ◽  
Viral Evolution ◽  
Antiretroviral Drug ◽  
Immunodeficiency Virus ◽  
And Shifts

ABSTRACT Antiretroviral drug therapy and cytotoxic T lymphocytes (CTL) both exert selective pressures on human immunodeficiency virus type 1, which influence viral evolution. Compared to chronically infected, antiretroviral-untreated patients, most chronically infected, treated patients with detectable viremia lack a cellular immune response against the Gag 77-85(SL9) epitope but show a new immunodominant response against an epitope in protease PR 76-84. Hence, mutations induced by antiretroviral therapy likely alter the profile of epitopes presented to T cells and thus the direction of the response. The consequences of dual pressures from treatment and CTL need to be considered in monitoring of drug therapy.

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