Highly Efficient Neutralization by Plasma Antibodies from Human Immunodeficiency Virus Type-1 Infected Individuals on Antiretroviral Drug Therapy

2014 ◽  
Vol 34 (4) ◽  
pp. 504-513 ◽  
Author(s):  
Raiees Andrabi ◽  
M. A. Makhdoomi ◽  
Rajesh Kumar ◽  
Manju Bala ◽  
Hilal Parray ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Drug Therapy ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Highly Efficient ◽  
Antiretroviral Drug ◽  
Immunodeficiency Virus

scholarly journals Antiretroviral Drug Therapy Alters the Profile of Human Immunodeficiency Virus Type 1-Specific T-Cell Responses and Shifts the Immunodominant Cytotoxic T-Lymphocyte Response from Gag to Pol

2007 ◽  
Vol 81 (20) ◽  
pp. 11543-11548 ◽  
Author(s):  
A. C. Karlsson ◽  
J. M. Chapman ◽  
B. D. Heiken ◽  
R. Hoh ◽  
E. G. Kallas ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Drug Therapy ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Cytotoxic T Lymphocyte ◽  
Viral Evolution ◽  
Antiretroviral Drug ◽  
Immunodeficiency Virus ◽  
And Shifts

ABSTRACT Antiretroviral drug therapy and cytotoxic T lymphocytes (CTL) both exert selective pressures on human immunodeficiency virus type 1, which influence viral evolution. Compared to chronically infected, antiretroviral-untreated patients, most chronically infected, treated patients with detectable viremia lack a cellular immune response against the Gag 77-85(SL9) epitope but show a new immunodominant response against an epitope in protease PR 76-84. Hence, mutations induced by antiretroviral therapy likely alter the profile of epitopes presented to T cells and thus the direction of the response. The consequences of dual pressures from treatment and CTL need to be considered in monitoring of drug therapy.

scholarly journals Dynamics of Human Immunodeficiency Virus Type 1 Replication in Vertically Infected Infants

1999 ◽  
Vol 73 (1) ◽  
pp. 362-367 ◽  
Author(s):  
Katherine Luzuriaga ◽  
Hulin Wu ◽  
Margaret McManus ◽  
Paula Britto ◽  
William Borkowsky ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Drug Regimen ◽  
Turnover Rates ◽  
Antiretroviral Drug ◽  
Immunodeficiency Virus ◽  
Hiv 1

ABSTRACT Plasma human immunodeficiency virus type 1 (HIV-1) turnover and kinetics were studied in children aged 15 days to 2 years following the initiation of a triple antiretroviral drug regimen consisting of zidovudine, lamivudine, and nevirapine. HIV-1 turnover was at least as rapid as that previously described in adults; turnover rates were more rapid in infants and children aged 3 months to 2 years than in infants less than 3 months of age. These data confirm the central role of HIV-1 replication in the pathogenesis of vertical HIV-1 infection and reinforce the importance of early, potent combination therapies for the long-term control of HIV-1 replication.

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