scholarly journals Unique V3 Loop Sequence Derived from the R2 Strain of HIV-Type 1 Elicits Broad Neutralizing Antibodies

2004 ◽  
Vol 20 (11) ◽  
pp. 1259-1268 ◽  
Author(s):  
Kelly R. Young ◽  
Benjamin E. Teal ◽  
Yvonne Brooks ◽  
Thomas D. Green ◽  
Joseph F. Bower ◽  
...  
Keyword(s):  
Neutralizing Antibodies ◽  
V3 Loop ◽  
Loop Sequence ◽  
Hiv Type 1

HIV Type 1 Subtype E-Infected Patients with Broadened, Dual (B/E) V3 Loop Serology Have Increased Cross-Neutralizing Antibodies

2001 ◽  
Vol 17 (1) ◽  
pp. 69-79 ◽  
Author(s):  
Victoria R. Polonis ◽  
Mark S. de Souza ◽  
Penprapa Chanbancherd ◽  
Somsak Chantakulkij ◽  
Achara Jugsudee ◽  
...  
Keyword(s):  
Neutralizing Antibodies ◽  
V3 Loop ◽  
Hiv Type 1

Contrasting IgA and IgG Neutralization Capacities and Responses to HIV Type 1 gp120 V3 Loop in HIV-Infected Individuals

1994 ◽  
Vol 10 (7) ◽  
pp. 813-822 ◽  
Author(s):  
PAMELA A. KOZLOWSKI ◽  
DEXIANG CHEN ◽  
JOHN H. ELDRIDGE ◽  
SUSAN JACKSON
Keyword(s):  
V3 Loop ◽  
Hiv Type 1

scholarly journals Structural Conservation Predominates Over Sequence Variability in the Crown of HIV Type 1's V3 Loop

2010 ◽  
Vol 26 (6) ◽  
pp. 717-723 ◽  
Author(s):  
David Almond ◽  
Tetsuya Kimura ◽  
XiangPeng Kong ◽  
James Swetnam ◽  
Susan Zolla-Pazner ◽  
...  
Keyword(s):  
V3 Loop ◽  
Sequence Variability ◽  
Hiv Type 1 ◽  
Structural Conservation

Tin Protoporphyrin IX Used in Control of Heme Metabolism in Humans Effectively Inhibits HIV-1 Infection

1994 ◽  
Vol 5 (5) ◽  
pp. 322-330 ◽  
Author(s):  
A. R. Neurath ◽  
N. Strick ◽  
K. Lin ◽  
A. K. Debnath ◽  
S. Jiang
Keyword(s):  
Protoporphyrin Ix ◽  
V3 Loop ◽  
Gp 120 ◽  
Loop Sequence ◽  
Immunodeficiency Virus ◽  
Cd4 Binding Site ◽  
Glycoprotein Gp120 ◽  
Tin Protoporphyrin ◽  
Hiv 1

Recent observations indicated that several porphyrins bound to the V3 loop of the envelope glycoprotein gp120 of the human immunodeficiency virus type 1 (HIV-1) and inhibited infection of cells by HIV-1. The tin derivative of protoporphyrin IX (Sn-PTP-IX) has already been used clinically in humans to suppress hyperbilirubinemia. It was therefore of interest to determine whether Sn-PTP-IX has anti-HIV-1 activity. It is demonstrated here that Sn-PTP-IX effectively inhibited infection by several HIV-1 isolates (HIB, MN, RF, SF-2 and two isolates resistant to azidothymidine). This was surprising, since earlier studies indicated that incorporation of other metals into porphyrins markedly decreased their antiviral activity. Sn-PTP-IX blocked the binding to gp120 of anti-V3-loop-specific antibodies and of monoclonal antibodies specific for the CD4 binding site on gp120. The latter effect appeared to be allosteric and was not observed with a deletion mutant of gp 120 lacking the V3 loop sequence. This suggests that Sn-PTP-IX binds to the V3 loop and distorts the native conformation of the HIV-1 envelope, thereby preventing infection. These results merit the consideration of Sn-PTP-IX as a prophylactic and chemotherapeutic agent against HIV-1.

Short Communication: In VitroSynergy between Peptides or Neutralizing Antibodies Targeting the N- and C-Terminal Heptad Repeats of HIV Type 1 gp41

2008 ◽  
Vol 24 (12) ◽  
pp. 1537-1544 ◽  
Author(s):  
Renee Hrin ◽  
Donna L. Montgomery ◽  
Fubao Wang ◽  
Jon H. Condra ◽  
Zhiqiang An ◽  
...  
Keyword(s):  
Neutralizing Antibodies ◽  
Short Communication ◽  
Hiv Type 1 ◽  
Heptad Repeats
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