V3 Loop of Human Immunodeficiency Virus Type 1 Reduces Cyclin E Expression and Induces G1Arrest in Interleukin 2-Dependent T Cells

1998 ◽  
Vol 14 (1) ◽  
pp. 31-38 ◽  
Author(s):  
HITOSHI SAKAIDA ◽  
SHIN KAWAMATA ◽  
TOSHIO HATTORI ◽  
TAKASHI UCHIYAMA
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cells ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Cyclin E ◽  
Interleukin 2 ◽  
V3 Loop ◽  
Immunodeficiency Virus

scholarly journals Human Immunodeficiency Virus Type 1-Specific Immune Responses in Primates upon Sequential Immunization with Adenoviral Vaccine Carriers of Human and Simian Serotypes

2004 ◽  
Vol 78 (14) ◽  
pp. 7392-7399 ◽  
Author(s):  
A. Reyes-Sandoval ◽  
J. C. Fitzgerald ◽  
R. Grant ◽  
S. Roy ◽  
Z. Q. Xiang ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cells ◽  
Immune Responses ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Interleukin 2 ◽  
Cell Subset ◽  
Immunodeficiency Virus ◽  
Adenoviral Vaccine

ABSTRACT Two triple immunization vaccine regimens with adenoviral vectors with E1 deleted expressing Gag of human immunodeficiency virus type 1 were tested for induction of T- and B-cell-mediated-immune responses in mice and in nonhuman primates. The vaccine carriers were derived from distinct serotypes of human and simian adenoviruses that fail to elicit cross-neutralizing antibodies expected to dampen the effect of booster immunizations. Both triple immunization regimens induced unprecedented frequencies of gamma interferon-producing CD8+ T cells to Gag in mice and monkeys that remained remarkably stable over time. In addition, monkeys developed Gag-specific interleukin-2-secreting T cells, presumably belonging to the CD4+ T-cell subset, and antibodies to both Gag and the adenoviral vaccine carriers.

V3 Loop of Human Immunodeficiency Virus Type 1 Suppresses Interleukin 2-Induced T Cell Growth

1997 ◽  
Vol 13 (2) ◽  
pp. 151-159 ◽  
Author(s):  
HITOSHI SAKAIDA ◽  
TOSHIO MURAKAMI ◽  
SHIN KAWAMATA ◽  
TOSHIO HATTORI ◽  
TAKASHI UCHIYAMA
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cell ◽  
Cell Growth ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Interleukin 2 ◽  
V3 Loop ◽  
Immunodeficiency Virus ◽  
T Cell Growth

scholarly journals Human immunodeficiency virus type 1 Tat increases cooperation between AP-1 and NFAT transcription factors in T cells

2006 ◽  
Vol 87 (6) ◽  
pp. 1603-1612 ◽  
Author(s):  
Alicia M. Hidalgo-Estévez ◽  
Esther González ◽  
Carmen Punzón ◽  
Manuel Fresno
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cells ◽  
Transcription Factors ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Nuclear Translocation ◽  
Interleukin 2 ◽  
Immunodeficiency Virus ◽  
Hiv 1

Human immunodeficiency virus type 1 (HIV-1) Tat affects cellular gene expression through modulation of the activity of different transcription factors. Here, the role of Tat in the cooperation between nuclear factor of activated T cells (NFAT) and activator protein 1 (AP-1) transcription factors was investigated. Constitutive or transient Tat expression in Jurkat T cells enhanced cooperative NFAT/AP-1- but not AP-1-dependent transcription independent of its ability to transactivate the HIV-1 LTR. The enhancing effect of Tat took place after nuclear translocation of NFAT. Furthermore, transactivation of an NFAT/AP-1 reporter by transfection of NFAT and c-Jun was strongly enhanced by simultaneous Tat transfection. Moreover, intracellular Tat expression increased the binding of NFAT/AP-1 complexes to the interleukin 2 promoter without significantly altering NFAT- and AP-1-independent binding. HIV-1 Tat interacted with NFAT but not c-Jun. These results indicate that Tat interacts with NFAT, affecting its cooperation with AP-1, without altering independent binding of these transcription factors to DNA.

Conserved V3 Loop Sequences and Transmission of Human Immunodeficiency Virus Type 1

1994 ◽  
Vol 10 (12) ◽  
pp. 1679-1684 ◽  
Author(s):  
EUGENE G. SHPAER ◽  
ERIC L. DELWART ◽  
CARLA L. KUIKEN ◽  
JAAP GOUDSMIT ◽  
MICHAEL H. BACHMANN ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
V3 Loop ◽  
Immunodeficiency Virus
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