scholarly journals Extracellular Matrix Remodeling: The Common Denominator in Connective Tissue DiseasesPossibilities for Evaluation and Current Understanding of the Matrix as More Than a Passive Architecture, but a Key Player in Tissue Failure

2013 ◽  
Vol 11 (2) ◽  
pp. 70-92 ◽  
Author(s):  
Morten A. Karsdal ◽  
Mette J. Nielsen ◽  
Jannie M. Sand ◽  
Kim Henriksen ◽  
Federica Genovese ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Connective Tissue ◽  
Current Understanding ◽  
Extracellular Matrix Remodeling ◽  
Common Denominator ◽  
Matrix Remodeling ◽  
The Matrix ◽  
The Common

scholarly journals Induction of Extracellular Matrix-Remodeling Genes by the Senescence-Associated Protein APA-1

2002 ◽  
Vol 22 (21) ◽  
pp. 7385-7397 ◽  
Author(s):  
Jennifer A. Benanti ◽  
Dawnnica K. Williams ◽  
Kristin L. Robinson ◽  
Harvey L. Ozer ◽  
Denise A. Galloway
Keyword(s):  
Cell Cycle ◽  
Extracellular Matrix ◽  
Zinc Finger Protein ◽  
Kinase Inhibitor ◽  
Human Fibroblasts ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling ◽  
Telomere Attrition ◽  
Cyclin Dependent Kinase Inhibitor ◽  
The Matrix

ABSTRACT Human fibroblasts undergo cellular senescence after a finite number of divisions, in response to the erosion of telomeres. In addition to being terminally arrested in the cell cycle, senescent fibroblasts express genes that are normally induced upon wounding, including genes that remodel the extracellular matrix. We have identified the novel zinc finger protein APA-1, whose expression increased in senescent human fibroblasts independent of telomere shortening. Extended passage, telomerase-immortalized fibroblasts had increased levels of APA-1 as well as the cyclin-dependent kinase inhibitor p16. In fibroblasts, APA-1 was modified by the ubiquitin-like protein SUMO-1, which increased APA-1 half-life, possibly by blocking ubiquitin-mediated degradation. Overexpression of APA-1 did not cause cell cycle arrest; but, it induced transcription of the extracellular matrix-remodeling genes MMP1 and PAI2, which are associated with fibroblast senescence. MMP1 and PAI2 transcript levels also increased in telomerase-immortalized fibroblasts that had high levels of APA-1, demonstrating that the matrix-remodeling phenotype of senescent fibroblasts was not induced by telomere attrition alone. APA-1 was able to transactivate and bind to the MMP1 promoter, suggesting that APA-1 is a transcription factor that regulates expression of matrix-remodeling genes during fibroblast senescence.

The matrix reorganized: extracellular matrix remodeling and integrin signaling

2006 ◽  
Vol 18 (5) ◽  
pp. 463-471 ◽  
Author(s):  
Melinda Larsen ◽  
Vira V Artym ◽  
J Angelo Green ◽  
Kenneth M Yamada
Keyword(s):  
Extracellular Matrix ◽  
Integrin Signaling ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling ◽  
The Matrix

scholarly journals The Dynamic Interaction between Extracellular Matrix Remodeling and Breast Tumor Progression

Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1046
Author(s):  
Jorge Martinez ◽  
Patricio C. Smith
Keyword(s):  
Extracellular Matrix ◽  
Type I Collagen ◽  
Cell Metabolism ◽  
Breast Tumors ◽  
Extracellular Matrix Remodeling ◽  
Type I ◽  
Matrix Remodeling ◽  
Desmoplastic Reaction ◽  
The Impact

Desmoplastic tumors correspond to a unique tissue structure characterized by the abnormal deposition of extracellular matrix. Breast tumors are a typical example of this type of lesion, a property that allows its palpation and early detection. Fibrillar type I collagen is a major component of tumor desmoplasia and its accumulation is causally linked to tumor cell survival and metastasis. For many years, the desmoplastic phenomenon was considered to be a reaction and response of the host tissue against tumor cells and, accordingly, designated as “desmoplastic reaction”. This notion has been challenged in the last decades when desmoplastic tissue was detected in breast tissue in the absence of tumor. This finding suggests that desmoplasia is a preexisting condition that stimulates the development of a malignant phenotype. With this perspective, in the present review, we analyze the role of extracellular matrix remodeling in the development of the desmoplastic response. Importantly, during the discussion, we also analyze the impact of obesity and cell metabolism as critical drivers of tissue remodeling during the development of desmoplasia. New knowledge derived from the dynamic remodeling of the extracellular matrix may lead to novel targets of interest for early diagnosis or therapy in the context of breast tumors.

scholarly journals Aryl Hydrocarbon Receptor Activation Impairs Extracellular Matrix Remodeling during Zebra Fish fin Regeneration

2006 ◽  
Vol 95 (1) ◽  
pp. 215-226 ◽  
Author(s):  
Eric A. Andreasen ◽  
Lijoy K. Mathew ◽  
Christiane V. Löhr ◽  
Rachelle Hasson ◽  
Robert L. Tanguay
Keyword(s):  
Extracellular Matrix ◽  
Aryl Hydrocarbon Receptor ◽  
Receptor Activation ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling ◽  
Zebra Fish ◽  
Fin Regeneration ◽  
Aryl Hydrocarbon

Umbilical artery extracellular matrix remodeling in fetal growth restriction

2004 ◽  
Vol 191 (6) ◽  
pp. S10
Author(s):  
Wendy Kinzler ◽  
John Smulian ◽  
C. Andrew Kistler ◽  
Rita Hahn ◽  
Peihong Zhou ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Umbilical Artery ◽  
Growth Restriction ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling

Identification of Differentially Expressed Genes in Human Varicose Veins: Involvement of Matrix Gla Protein in Extracellular Matrix Remodeling

2007 ◽  
Vol 44 (6) ◽  
pp. 444-459 ◽  
Author(s):  
Chrystelle Cario-Toumaniantz ◽  
Cédric Boularan ◽  
Leon J. Schurgers ◽  
Marie-Françoise Heymann ◽  
Martine Le Cunff ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Differentially Expressed Genes ◽  
Varicose Veins ◽  
Matrix Gla Protein ◽  
Differentially Expressed ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling
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