Chinese Herbal Medicine Decreases Incidence of Cirrhosis in Patients with Non-Alcoholic Fatty Liver Disease in Taiwan: A Propensity Score-Matched Cohort Study

2021 ◽  
Author(s):  
Chia-Yu Huang ◽  
Mei-Yao Wu ◽  
Hsiang-Chi Wang ◽  
Yuan-Ching Liao ◽  
Sio-Ian Tou ◽  
...  
Keyword(s):  
Cohort Study ◽  
Liver Disease ◽  
Herbal Medicine ◽  
Propensity Score ◽  
Chinese Herbal Medicine ◽  
Fatty Liver Disease ◽  
Matched Cohort ◽  
Alcoholic Fatty Liver ◽  
Chinese Herbal ◽  
Alcoholic Fatty Liver Disease

scholarly journals Acupuncture combined with Chinese herbal medicine on non-alcoholic fatty liver disease

Medicine ◽  
2021 ◽  
Vol 100 (51) ◽  
pp. e28083
Author(s):  
Yuan Ma ◽  
Kewei Sun ◽  
Jianzhong Cao ◽  
Xiaowu Qin ◽  
Jiaoling Shi ◽  
...  
Keyword(s):  
Liver Disease ◽  
Herbal Medicine ◽  
Fatty Liver ◽  
Chinese Herbal Medicine ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Chinese Herbal ◽  
Alcoholic Fatty Liver Disease

scholarly journals Chinese Herbal Medicine Is Helpful for Survival Improvement in Patients With Multiple Myeloma in Taiwan: A Nationwide Retrospective Matched-Cohort Study

2020 ◽  
Vol 19 ◽  
pp. 153473542094328
Author(s):  
Chia-Yu Huang ◽  
Mei-Yao Wu ◽  
Yu-Hung Kuo ◽  
Sio-Ian Tou ◽  
Hung-Rong Yen
Keyword(s):  
Multiple Myeloma ◽  
Cohort Study ◽  
Herbal Medicine ◽  
Propensity Score ◽  
Chinese Herbal Medicine ◽  
Cox Regression ◽  
Research Database ◽  
Matched Cohort ◽  
Matched Cohort Study ◽  
Chinese Herbal

Aim of the Study: The purpose of this study is to demonstrate that Chinese herbal medicine is beneficial for survival improvement in patients with multiple myeloma. Materials and Methods: We performed a 1:1 propensity score–matched cohort study to analyze patients with multiple myeloma diagnosed between January 1, 2002, and December 31, 2012, through the Taiwanese National Health Insurance Research Database. Patients who received Chinese herbal medicine therapy from the initial date of diagnosis of multiple myeloma to December 31, 2012, were included in the Chinese herbal medicine group. Patients who were not treated with Chinese herbal medicine during the same interval were categorized in the non-Chinese herbal medicine group. A Cox regression model was used to adjust for sex, age, comorbidities, and drug use. Hazard ratios were also compared between the 2 groups. Results: A total of 312 patients were identified after 1:1 propensity score matching. The patients had similar basic characteristics. A better survival status was found in the Chinese herbal medicine cohort (log-rank test, P < .0001). Finally, 49 patients in the Chinese herbal medicine cohort and 96 patients in the non-Chinese herbal medicine cohort died (adjusted hazard ratio = 0.35, 95% confidence interval = 0.24-0.51). The effect of survival improvement from Chinese herbal medicine in patients with multiple myeloma could be observed when prescriptions had the duration of ≥30 days. Conclusions: Our results showed that patients with multiple myeloma could benefit from Chinese herbal medicine treatment, which could improve the survival rate in Taiwan. The findings offer important ideas for further study.

scholarly journals De novo Portal Vein Thrombosis in Non-Cirrhotic Non-Alcoholic Fatty Liver Disease: A 9-Year Prospective Cohort Study

2021 ◽  
Vol 8 ◽  
Author(s):  
Ahmed Abdel-Razik ◽  
Nasser Mousa ◽  
Walaa Shabana ◽  
Ahmed H. Yassen ◽  
Mostafa Abdelsalam ◽  
...  
Keyword(s):  
Cohort Study ◽  
Liver Disease ◽  
Portal Vein ◽  
Fatty Liver ◽  
Portal Vein Thrombosis ◽  
Prospective Cohort ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Vein Thrombosis ◽  
Alcoholic Fatty Liver Disease

Background and Aims: Approximately 30–40% of portal vein thrombosis (PVT) remains of unknown origin. The association between non-alcoholic fatty liver disease (NAFLD) and PVT is a matter of debate. This study aimed to investigate the association between PVT and NAFLD.Methods: We included 94 out of 105 consecutive NAFLD patients in this prospective cohort study in addition to 94 from the healthy control group. We evaluated biochemical, clinical, immunological, and histopathological parameters; waist circumference (WC); leptin; adiponectin; and leptin/adiponectin ratio (LAR) for all participants at baseline and every 3 years thereafter. We described the characteristics of participants at baseline and showed individual WC, LAR, and PVT characteristics. Potential parameters to predict PVT development within 9 years were determined.Results: PVT developed in eight (8.5%) patients, mainly in the portal trunk. Univariate analysis showed three PVT-associated factors: diabetes mellitus (P = 0.013), WC (P &lt; 0.001), and LAR (P = 0.002). After adjusting multiple confounding variables, the multivariate model showed that the only significant variables were WC and LAR. By applying the receiver operating characteristic curve, WC had 98.8% specificity, 87.5% sensitivity, and 0.894 area under the curve (AUC) for prediction of PVT (P &lt; 0.001) at cutoff values of &gt; 105 cm. In comparison, LAR had 60.5% specificity, 87.5% sensitivity, and 0.805 AUC for PVT prediction (P &lt; 0.001) at cutoff values of &gt;7.5.Conclusions: This study suggests that increased central obesity and LAR were independently associated with PVT development in non-cirrhotic NAFLD patients, and they should be considered risk factors that may participate in PVT multifactorial pathogenesis.

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