Relationship between V3 Sequences of HIV Type 1 from Plasma, T Cells, and Dendritic Cells Suggests that Plasma Virus May Arise from Different Cell Sources

2001 ◽  
Vol 17 (2) ◽  
pp. 179-184 ◽  
Author(s):  
S. Patterson ◽  
N.R. English ◽  
H. Longhurst ◽  
P. Jain ◽  
P. Balfe ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Plasma Virus ◽  
Cell Sources ◽  
Hiv Type 1

scholarly journals Monocyte‐Derived Dendritic Cells from HIV Type 1–Infected Individuals Show Reduced Ability to Stimulate T Cells and Have Altered Production of Interleukin (IL)–12 and IL‐10

2009 ◽  
Vol 199 (12) ◽  
pp. 1862-1871 ◽  
Author(s):  
Sandrine Buisson ◽  
Adel Benlahrech ◽  
Brian Gazzard ◽  
Frances Gotch ◽  
Peter Kelleher ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Hiv Type 1

Selective Transmission of R5-Tropic HIV Type 1 from Dendritic Cells to Resting CD4+T Cells

2001 ◽  
Vol 17 (1) ◽  
pp. 59-68 ◽  
Author(s):  
S.A. David ◽  
M.S. Smith ◽  
G.J. Lopez ◽  
I. Adany ◽  
S. Mukherjee ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Cd4 T Cells ◽  
Hiv Type 1

The Role of Human T-Lymphotropic Virus Type 1 (HTLV-1)-Infected Dendritic Cells in the Development of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis

1999 ◽  
Vol 73 (6) ◽  
pp. 4575-4581 ◽  
Author(s):  
Masahiko Makino ◽  
Satoshi Shimokubo ◽  
Shin-Ichi Wakamatsu ◽  
Shuji Izumo ◽  
Masanori Baba
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Virus Type ◽  
Spastic Paraparesis ◽  
Tropical Spastic Paraparesis ◽  
Normal Donor ◽  
Dependent Manner ◽  
T Lymphotropic Virus

ABSTRACT The development of human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is closely associated with the activation of T cells which are HTLV-1 specific but may cross-react with neural antigens (Ags). Immature dendritic cells (DCs), differentiated from normal donor monocytes by using recombinant granulocyte-macrophage colony-stimulating factor and recombinant interleukin-4, were pulsed with HTLV-1 in vitro. The pulsed DCs contained HTLV-1 proviral DNA and expressed HTLV-1 Gag Ag on their surface 6 days after infection. The DCs matured by lipopolysaccharides stimulated autologous CD4+ T cells and CD8+ T cells in a viral dose-dependent manner. However, the proliferation level of CD4+ T cells was five- to sixfold higher than that of CD8+ T cells. In contrast to virus-infected DCs, DCs pulsed with heat-inactivated virions activated only CD4+ T cells. To clarify the role of DCs in HAM/TSP development, monocytes from patients were cultured for 4 days in the presence of the cytokines. The expression of CD86 Ag on DCs was higher and that of CD1a Ag was more down-regulated than in DCs generated from normal monocytes. DCs from two of five patients expressed HTLV-1 Gag Ag. Furthermore, both CD4+ and CD8+ T cells from the patients were greatly stimulated by contact with autologous DCs pulsed with inactivated viral Ag as well as HTLV-1-infected DCs. These results suggest that DCs are susceptible to HTLV-1 infection and that their cognate interaction with T cells may contribute to the development of HAM/TSP.

scholarly journals Differential Transmission of Human Immunodeficiency Virus Type 1 by Distinct Subsets of Effector Dendritic Cells

2002 ◽  
Vol 76 (15) ◽  
pp. 7812-7821 ◽  
Author(s):  
Rogier W. Sanders ◽  
Esther C. de Jong ◽  
Christopher E. Baldwin ◽  
Joost H. N. Schuitemaker ◽  
Martien L. Kapsenberg ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cells ◽  
Dendritic Cells ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Virus Transmission ◽  
Viral Envelope ◽  
Immunodeficiency Virus ◽  
Hiv 1

ABSTRACT Dendritic cells (DC) support human immunodeficiency virus type 1 (HIV-1) transmission by capture of the virus particle in the mucosa and subsequent transport to the draining lymph node, where HIV-1 is presented to CD4+ Th cells. Virus transmission involves a high-affinity interaction between the DC-specific surface molecule DC-SIGN and the viral envelope glycoprotein gp120 and subsequent internalization of the virus, which remains infectious. The mechanism of viral transmission from DC to T cells is currently unknown. Sentinel immature DC (iDC) develop into Th1-promoting effector DC1 or Th2-promoting DC2, depending on the activation signals. We studied the ability of these effector DC subsets to support HIV-1 transmission in vitro. Compared with iDC, virus transmission is greatly upregulated for the DC1 subset, whereas DC2 cells are inactive. Increased transmission by DC1 correlates with increased expression of ICAM-1, and blocking studies confirm that ICAM-1 expression on DC is important for HIV transmission. The ICAM-1-LFA-1 interaction is known to be important for immunological cross talk between DC and T cells, and our results indicate that this cell-cell contact is exploited by HIV-1 for efficient transmission.

Allogeneic Dendritic Cell Induction of HIV-Specific Cytotoxic T Lymphocyte Responses from T Cells of HIV Type 1-Infected and Uninfected Individuals

1997 ◽  
Vol 13 (1) ◽  
pp. 33-39 ◽  
Author(s):  
MARC DUPUIS ◽  
MADHUSUDAN V. PESHWA ◽  
CLAUDIA BENIKE ◽  
SMRITI K. KUNDU ◽  
EDGAR G. ENGLEMAN ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cell ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Cell Induction ◽  
Hiv Type 1 ◽  
Lymphocyte Responses

Ex VivoExpansion of HIV Type 1-Specific Cytolytic T Cells from HIV Type 1-Seropositive Subjects

1995 ◽  
Vol 11 (2) ◽  
pp. 257-271 ◽  
Author(s):  
JUDY LIEBERMAN ◽  
JESSICA A. FABRY ◽  
PREMLATA SHANKAR ◽  
LAUREL BECKETT ◽  
PAUL R. SKOLNIK
Keyword(s):  
T Cells ◽  
Hiv Type 1

scholarly journals Clearance of HIV Type 1 Envelope Recombinant Sendai Virus Depends on CD4+T Cells and Interferon-γ But Not B Cells, CD8+T Cells, or Perforin

2010 ◽  
Vol 26 (7) ◽  
pp. 783-793 ◽  
Author(s):  
Sherri L. Surman ◽  
Scott A. Brown ◽  
Bart G. Jones ◽  
David L. Woodland ◽  
Julia L. Hurwitz
Keyword(s):  
T Cells ◽  
B Cells ◽  
Cd8 T Cells ◽  
Cd4 T Cells ◽  
Sendai Virus ◽  
Interferon Γ ◽  
Hiv Type 1
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