Selective Transmission of R5-Tropic HIV Type 1 from Dendritic Cells to Resting CD4+T Cells

2001 ◽  
Vol 17 (1) ◽  
pp. 59-68 ◽  
Author(s):  
S.A. David ◽  
M.S. Smith ◽  
G.J. Lopez ◽  
I. Adany ◽  
S. Mukherjee ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Cd4 T Cells ◽  
Hiv Type 1

scholarly journals Monocyte‐Derived Dendritic Cells from HIV Type 1–Infected Individuals Show Reduced Ability to Stimulate T Cells and Have Altered Production of Interleukin (IL)–12 and IL‐10

2009 ◽  
Vol 199 (12) ◽  
pp. 1862-1871 ◽  
Author(s):  
Sandrine Buisson ◽  
Adel Benlahrech ◽  
Brian Gazzard ◽  
Frances Gotch ◽  
Peter Kelleher ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Hiv Type 1

scholarly journals Clearance of HIV Type 1 Envelope Recombinant Sendai Virus Depends on CD4+T Cells and Interferon-γ But Not B Cells, CD8+T Cells, or Perforin

2010 ◽  
Vol 26 (7) ◽  
pp. 783-793 ◽  
Author(s):  
Sherri L. Surman ◽  
Scott A. Brown ◽  
Bart G. Jones ◽  
David L. Woodland ◽  
Julia L. Hurwitz
Keyword(s):  
T Cells ◽  
B Cells ◽  
Cd8 T Cells ◽  
Cd4 T Cells ◽  
Sendai Virus ◽  
Interferon Γ ◽  
Hiv Type 1

scholarly journals TLR2 Signaling Renders Quiescent Naive and Memory CD4+T Cells More Susceptible to Productive Infection with X4 and R5 HIV-Type 1

2007 ◽  
Vol 179 (7) ◽  
pp. 4357-4366 ◽  
Author(s):  
Sandra Thibault ◽  
Mélanie R. Tardif ◽  
Corinne Barat ◽  
Michel J. Tremblay
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Productive Infection ◽  
Hiv Type 1 ◽  
Memory Cd4 T Cells ◽  
Tlr2 Signaling

scholarly journals Both CD31+and CD31−Naive CD4+T Cells Are Persistent HIV Type 1–Infected Reservoirs in Individuals Receiving Antiretroviral Therapy

2010 ◽  
Vol 202 (11) ◽  
pp. 1738-1748 ◽  
Author(s):  
Fiona Wightman ◽  
Ajantha Solomon ◽  
Gabriela Khoury ◽  
Justin A. Green ◽  
Lachlan Gray ◽  
...  
Keyword(s):  
T Cells ◽  
Antiretroviral Therapy ◽  
Cd4 T Cells ◽  
Hiv Type 1

scholarly journals Epigenetic Repression of Interleukin 2 Expression in Senescent CD4+T Cells During Chronic HIV Type 1 Infection

2014 ◽  
Vol 211 (1) ◽  
pp. 28-39 ◽  
Author(s):  
Kaori Nakayama-Hosoya ◽  
Takaomi Ishida ◽  
Ben Youngblood ◽  
Hitomi Nakamura ◽  
Noriaki Hosoya ◽  
...  
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Interleukin 2 ◽  
Hiv Type 1 ◽  
Epigenetic Repression

Interleukin-7 Induces HIV Type 1 Outgrowth From Peripheral Resting CD4+ T Cells

2004 ◽  
Vol 36 (5) ◽  
pp. 1103-1104 ◽  
Author(s):  
Ginger Lehrman ◽  
Loyda Ylisastigui ◽  
Ronald J. Bosch ◽  
David M. Margolis
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Interleukin 7 ◽  
Hiv Type 1

Long HIV Type 1 Reverse Transcripts Can Accumulate Stably within Resting CD4+T Cells While Short Ones Are Degraded

2004 ◽  
Vol 20 (3) ◽  
pp. 285-295 ◽  
Author(s):  
William J. Swiggard ◽  
Una O'Doherty ◽  
David McGain ◽  
Deepa Jeyakumar ◽  
Michael H. Malim
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Hiv Type 1

scholarly journals Productive Infection of Plasmacytoid Dendritic Cells with Human Immunodeficiency Virus Type 1 Is Triggered by CD40 Ligation

2002 ◽  
Vol 76 (21) ◽  
pp. 11033-11041 ◽  
Author(s):  
Lawrence Fong ◽  
Manuela Mengozzi ◽  
Nancy W. Abbey ◽  
Brian G. Herndier ◽  
Edgar G. Engleman
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cells ◽  
Dendritic Cells ◽  
Viral Replication ◽  
Cd4 T Cells ◽  
Cd40 Ligand ◽  
Immunodeficiency Virus ◽  
Hiv 1

ABSTRACT Immature plasmacytoid dendritic cells are the principal alpha interferon-producing cells (IPC), responsible for primary antiviral immunity. IPC express surface molecules CD4, CCR5, and CXCR4, which are known coreceptors required for human immunodeficiency virus (HIV) infection. Here we show that IPC are susceptible to and replicate HIV type 1 (HIV-1). Importantly, viral replication is triggered upon activation of IPC with CD40 ligand, a signal physiologically delivered by CD4 T cells. Immunohistochemical staining of tonsil from HIV-infected individuals reveals HIV p24+ IPC, consistent with in vivo infection of these cells. IPC exposed in vitro to HIV produce alpha interferon, which partially inhibits viral replication. Nevertheless, IPC efficiently transmit HIV-1 to CD4 T-cells, and such transmission is also augmented by CD40 ligand activation. IPC produce RANTES/CCL5 and MIP-1α/CCL3 when exposed to HIV in vitro. IPC also induce naïve CD4 T cells to proliferate and would therefore preferentially infect these cells. These results indicate that IPC may play an important role in the dissemination of HIV.

scholarly journals Normal Telomere Lengths in Naive and Memory CD4+ T Cells in HIV Type 1 Infection: A Mathematical Interpretation

1999 ◽  
Vol 15 (12) ◽  
pp. 1053-1062 ◽  
Author(s):  
Katja C. Wolthers ◽  
Andre J. Noest ◽  
Sigrid A. Otto ◽  
Frank Miedema ◽  
Rob J. De Boer
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Hiv Type 1 ◽  
Memory Cd4 T Cells ◽  
Mathematical Interpretation

scholarly journals Host Factor Transcriptional Regulation Contributes to Preferential Expression of HIV Type 1 in IL-4–Producing CD4 T Cells

2012 ◽  
Vol 189 (6) ◽  
pp. 2746-2757 ◽  
Author(s):  
Mingce Zhang ◽  
Adrian Clausell ◽  
Tanya Robinson ◽  
Jiyi Yin ◽  
Eric Chen ◽  
...  
Keyword(s):  
T Cells ◽  
Transcriptional Regulation ◽  
Cd4 T Cells ◽  
Host Factor ◽  
Preferential Expression ◽  
Hiv Type 1
Sign in / Sign up

Export Citation Format

Share Document