Vertebrate Development: Maternal to Zygotic Control. Advances in Experimental Medicine and Biology, Volume 953. Edited by Francisco Pelegri, Michael Danilchik, and Ann Sutherland. Cham (Switzerland): Springer. $239.00. x + 549 p.; ill.; index. ISBN: 978-3-319-46093-2 (hc); 978-3-319-46095-6 (eb). 2017.

2018 ◽  
Vol 93 (4) ◽  
pp. 384-384
Keyword(s):  
Experimental Medicine ◽  
Vertebrate Development ◽  
Zygotic Control

Biomedical Odysseys

2017 ◽  
Author(s):  
Priscilla Song
Keyword(s):  
Surgical Intervention ◽  
Border Crossing ◽  
Biomedical Science ◽  
Experimental Medicine ◽  
Fetal Cell ◽  
Cell Therapies ◽  
Anthropology Of Science ◽  
Innovative Methods ◽  
Science Technology ◽  
Patient Activism

Thousands of people from more than eighty countries have traveled to China since 2001 to undergo fetal cell transplantation. Galvanized by the potential of stem and fetal cells to regenerate damaged neurons and restore lost bodily functions, people grappling with paralysis and neurodegenerative disorders have ignored the warnings of doctors and scientists back home in order to stake their futures on a Chinese experiment. This book looks at why and how these individuals have entrusted their lives to Chinese neurosurgeons operating at the forefront of experimental medicine, in a world where technologies and risks move faster than laws can keep pace. The book shows how cutting-edge medicine is not just about the latest advances in biomedical science but also encompasses transformations in online patient activism, surgical intervention, and borderline experiments in health care bureaucracy. The book opens up important theoretical and methodological horizons in the anthropology of science, technology, and medicine. It illuminates how poignant journeys in search of fetal cell cures become tangled in complex webs of digital mediation, the entrepreneurial logics of postsocialist medicine, and fraught debates about the ethics of clinical experimentation. Using innovative methods to track the border-crossing quests of Chinese clinicians and their patients from around the world, the book maps the transnational life of fetal cell therapies.

scholarly journals Biology and Physics of Heterochromatin-Like Domains/Complexes

Cells ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 1881
Author(s):  
Prim B. Singh ◽  
Stepan N. Belyakin ◽  
Petr P. Laktionov
Keyword(s):  
Phase Separation ◽  
Fission Yeast ◽  
Thermodynamic Description ◽  
Dynamic Structure ◽  
Vertebrate Development ◽  
Type Region ◽  
Additional Tool ◽  
3D Genome ◽  
Chromatin Template ◽  
Cis And Trans

The hallmarks of constitutive heterochromatin, HP1 and H3K9me2/3, assemble heterochromatin-like domains/complexes outside canonical constitutively heterochromatic territories where they regulate chromatin template-dependent processes. Domains are more than 100 kb in size; complexes less than 100 kb. They are present in the genomes of organisms ranging from fission yeast to human, with an expansion in size and number in mammals. Some of the likely functions of domains/complexes include silencing of the donor mating type region in fission yeast, preservation of DNA methylation at imprinted germline differentially methylated regions (gDMRs) and regulation of the phylotypic progression during vertebrate development. Far cis- and trans-contacts between micro-phase separated domains/complexes in mammalian nuclei contribute to the emergence of epigenetic compartmental domains (ECDs) detected in Hi-C maps. A thermodynamic description of micro-phase separation of heterochromatin-like domains/complexes may require a gestalt shift away from the monomer as the “unit of incompatibility” that determines the sign and magnitude of the Flory–Huggins parameter, χ. Instead, a more dynamic structure, the oligo-nucleosomal “clutch”, consisting of between 2 and 10 nucleosomes is both the long sought-after secondary structure of chromatin and its unit of incompatibility. Based on this assumption we present a simple theoretical framework that enables an estimation of χ for domains/complexes flanked by euchromatin and thereby an indication of their tendency to phase separate. The degree of phase separation is specified by χN, where N is the number of “clutches” in a domain/complex. Our approach could provide an additional tool for understanding the biophysics of the 3D genome.

Section of Pathology, Bacteriology and Experimental Medicine

1937 ◽  
Vol 2 (18) ◽  
pp. 759-763
Author(s):  
W. K. Inglis ◽  
H. A. Woodruff ◽  
G. C. Taylor ◽  
S. N. Michaels ◽  
R. E. Richards ◽  
...  
Keyword(s):  
Experimental Medicine

scholarly journals Digital Management Systems in Academic Health Sciences Laboratories: A Scoping Review

Healthcare ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 739
Author(s):  
Margareth Timóteo ◽  
Emanuelle Lourenço ◽  
Ana Carolina Brochado ◽  
Luciana Domenico ◽  
Joice da Silva ◽  
...  
Keyword(s):  
Scoping Review ◽  
Health Sciences ◽  
Management Systems ◽  
Experimental Medicine ◽  
Academic Health ◽  
Good Practices ◽  
High Staff Turnover ◽  
Digital Management ◽  
Good Laboratory ◽  
Management Reporting

Good laboratory practices (GLP) increase the quality and traceability of results in health sciences research. However, factors such as high staff turnover, insufficient resources, and a lack of training for managers may limit their implementation in research and academic laboratories. This Scoping Review aimed to identify digital tools for managing academic health sciences and experimental medicine laboratories and their relationship with good practices. Following the PRISMA-ScR 2018 criteria, a search strategy was conducted until April 2021 in the databases PUBMED, Web of Sciences, and Health Virtual Library. A critical appraisal of the selected references was conducted, followed by data charting. The search identified twenty-one eligible articles, mainly originated from high-income countries, describing the development and/or implementation of thirty-two electronic management systems. Most studies described software functionalities, while nine evaluated and discussed impacts on management, reporting both improvements in the workflow and system limitations during implementation. In general, the studies point to a contribution to different management issues related to GLP principles. In conclusion, this review identified evolving evidence that digital laboratory management systems may represent important tools in compliance with the principles of good practices in experimental medicine and health sciences research.

scholarly journals Second-order division in sectors as a prepattern for sensory organs in vertebrate development

2021 ◽  
Author(s):  
Vincent Fleury ◽  
Alexis Peaucelle ◽  
Anick Abourachid ◽  
Olivia Plateau
Keyword(s):  
Second Order ◽  
Vertebrate Development ◽  
Sensory Organs
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