scholarly journals Heparin‐Binding Protein: A Potential Biomarker in Sepsis?

2010 ◽  
Vol 50 (2) ◽  
pp. 283-284 ◽  
Author(s):  
Reetta Huttunen ◽  
Jaana Syrjänen
Keyword(s):  
Binding Protein ◽  
Protein A ◽  
Heparin Binding ◽  
Heparin Binding Protein ◽  
Potential Biomarker

scholarly journals Serum Heparin-Binding Protein as a Potential Biomarker to Distinguish Adult-Onset Still’s Disease From Sepsis

2021 ◽  
Vol 12 ◽  
Author(s):  
Rui Tian ◽  
Xia Chen ◽  
Chengde Yang ◽  
Jialin Teng ◽  
Hongping Qu ◽  
...  
Keyword(s):  
Roc Curve ◽  
Binding Protein ◽  
Adult Onset Still’S Disease ◽  
Heparin Binding ◽  
Adult Onset ◽  
Still’S Disease ◽  
Still's Disease ◽  
Heparin Binding Protein ◽  
Potential Biomarker ◽  
Adult Onset Still's Disease

Adult-onset Still’s disease (AOSD) is a systemic, multifactorial, autoinflammatory disease for which the etiopathogenesis is not well understood. Given the similarities in clinical and laboratory features between this disease and sepsis, and the differences in treatment strategies for these two diseases, specific diagnostic markers are crucial for the correct diagnosis and management of AOSD. Previous studies have shown plasma heparin-binding protein (HBP) is a promising potential biomarker for AOSD; thus, this study aimed to detect serum HBP levels in patients with AOSD or sepsis to assess its potential as a biomarker for differential diagnosis. We found that serum HBP levels were significantly higher in patients with active AOSD than that in those with inactive AOSD. Patients with sepsis had higher serum HBP levels compared with those who had active or inactive AOSD. We calculated the area under the receiver operating characteristic (ROC) curve to assess whether HBP could be used to differentiate active from inactive AOSD; this was 0.811 with sensitivity 0.650, specificity 0.811, and cutoff HBP value of 35.59 ng/ml. The area under the ROC curve for HBP as a biomarker to differentiate AOSD from sepsis was 0.653, with sensitivity 0.759, and specificity 0.552, and cutoff HBP value of 65.1 ng/ml. Taken together, the results of our study suggest that serum HBP could be a useful diagnostic biomarker to evaluate disease activity in patients with AOSD, and to differentiate AOSD from sepsis.

scholarly journals Heparin-Binding Protein: A Novel Biomarker Linking Four Different Cardiovascular Diseases

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Yufeng Cai ◽  
Xueyan Zhang ◽  
Jie Shen ◽  
Boyue Jiang ◽  
Dehua Hu ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Cardiovascular Diseases ◽  
Myocardial Ischemia ◽  
Signaling Pathways ◽  
Binding Protein ◽  
Protein A ◽  
Interaction Network ◽  
Heparin Binding ◽  
Gene Interaction Network ◽  
Heparin Binding Protein

Cardiovascular diseases are an important group of diseases that seriously affect quality of life. Thus, their treatment warrants further study. Heparin-binding protein (HBP) is a granulocyte protein derived from neutrophils. When an infection occurs, neutrophils release HBP, which can lead to elevated HBP levels in the blood. Therefore, HBP family members are said to be important indicators of infection. However, basic evidence is still lacking to confirm the possible relationship between HBP and cardiovascular diseases. Using bioinformatics methods, we investigated the role of the HBP network in normal hearts and hearts from patients with cardiovascular disease. First, we used the Open Targets database to obtain a list of HBP-encoding mRNAs related to atherosclerosis, myocarditis, myocardial infarction, and myocardial ischemia. Then, we constructed an HBP gene interaction network map using STRING. Clustering coefficients were calculated using Cytoscape, and MCODE was used for subnet analysis. Finally, the proposed interstitial network of HBPs was established and analyzed by Metascape enrichment analysis of the relevant signaling pathways. The aggregation coefficient of the HBP interaction network was higher among hearts with the four cardiovascular diseases, atherosclerosis (0.496), myocarditis (0.631), myocardial infarction (0.532), and myocardial ischemia (0.551), than in normal hearts. Metascape analysis showed that “NABA_MATRISOME_ASSOCIATED” was a typical pathway with the highest p value associated with epithelialization in all four diseases. Moreover, a large number of important HBPs were identified that may be significant for the treatment of these diseases. Therefore, HBPs do have a highly atopic connectivity network in cardiovascular diseases, and specific HBPs or signaling pathways may be used as targets for the development of new treatments for cardiovascular diseases.

Heparin-binding protein: A diagnostic marker of acute bacterial meningitis*

2011 ◽  
Vol 39 (4) ◽  
pp. 812-817 ◽  
Author(s):  
Adam Linder ◽  
Per Åkesson ◽  
Magnus Brink ◽  
Marie Studahl ◽  
Lars Björck ◽  
...  
Keyword(s):  
Bacterial Meningitis ◽  
Diagnostic Marker ◽  
Binding Protein ◽  
Protein A ◽  
Acute Bacterial Meningitis ◽  
Heparin Binding ◽  
Heparin Binding Protein

Neutrophil-derived heparin binding protein—A mediator of increased vascular permeability after burns?

Burns ◽  
2009 ◽  
Vol 35 (8) ◽  
pp. 1185-1187 ◽  
Author(s):  
Joakim Johansson ◽  
Lennart Lindbom ◽  
Heiko Herwald ◽  
Folke Sjöberg
Keyword(s):  
Vascular Permeability ◽  
Binding Protein ◽  
Protein A ◽  
Heparin Binding ◽  
Heparin Binding Protein

The heparin-binding protein interactome in pancreatic diseases

Pancreatology ◽  
2013 ◽  
Vol 13 (6) ◽  
pp. 598-604 ◽  
Author(s):  
Q.M. Nunes ◽  
V. Mournetas ◽  
B. Lane ◽  
R. Sutton ◽  
D.G. Fernig ◽  
...  
Keyword(s):  
Binding Protein ◽  
Heparin Binding ◽  
Pancreatic Diseases ◽  
Heparin Binding Protein ◽  
Protein Interactome

Heparin-binding protein (HBP/CAP37): A missing link in neutrophil-evoked alteration of vascular permeability

2001 ◽  
Vol 7 (10) ◽  
pp. 1123-1127 ◽  
Author(s):  
Narinder Gautam ◽  
A. Maria Olofsson ◽  
Heiko Herwald ◽  
Lars F. Iversen ◽  
Evy Lundgren-Åkerlund ◽  
...  
Keyword(s):  
Vascular Permeability ◽  
Binding Protein ◽  
Heparin Binding ◽  
Missing Link ◽  
Heparin Binding Protein

Human C21orf63 is a Heparin-binding Protein

2009 ◽  
Vol 146 (3) ◽  
pp. 369-373 ◽  
Author(s):  
Kanae Mitsunaga ◽  
Jun Harada-Itadani ◽  
Toshihide Shikanai ◽  
Hiroaki Tateno ◽  
Yuzuru Ikehara ◽  
...  
Keyword(s):  
Binding Protein ◽  
Heparin Binding ◽  
Heparin Binding Protein
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