Heparin-binding protein (HBP/CAP37): A missing link in neutrophil-evoked alteration of vascular permeability

2001 ◽  
Vol 7 (10) ◽  
pp. 1123-1127 ◽  
Author(s):  
Narinder Gautam ◽  
A. Maria Olofsson ◽  
Heiko Herwald ◽  
Lars F. Iversen ◽  
Evy Lundgren-Åkerlund ◽  
...  
Keyword(s):  
Vascular Permeability ◽  
Binding Protein ◽  
Heparin Binding ◽  
Missing Link ◽  
Heparin Binding Protein

Leukotriene B 4 ‐ induced changes in vascular permeability are mediated by neutrophil release of heparin‐binding protein (HBP/CAP37/azurocidin)

2009 ◽  
Vol 23 (6) ◽  
pp. 1750-1757 ◽  
Author(s):  
Antonio Di Gennaro ◽  
Ellinor Kenne ◽  
Min Wan ◽  
Oliver Soehnlein ◽  
Lennart Lindbom ◽  
...  
Keyword(s):  
Vascular Permeability ◽  
Binding Protein ◽  
Heparin Binding ◽  
Heparin Binding Protein ◽  
Induced Changes

Neutrophil-derived heparin binding protein—A mediator of increased vascular permeability after burns?

Burns ◽  
2009 ◽  
Vol 35 (8) ◽  
pp. 1185-1187 ◽  
Author(s):  
Joakim Johansson ◽  
Lennart Lindbom ◽  
Heiko Herwald ◽  
Folke Sjöberg
Keyword(s):  
Vascular Permeability ◽  
Binding Protein ◽  
Protein A ◽  
Heparin Binding ◽  
Heparin Binding Protein

The heparin-binding protein interactome in pancreatic diseases

Pancreatology ◽  
2013 ◽  
Vol 13 (6) ◽  
pp. 598-604 ◽  
Author(s):  
Q.M. Nunes ◽  
V. Mournetas ◽  
B. Lane ◽  
R. Sutton ◽  
D.G. Fernig ◽  
...  
Keyword(s):  
Binding Protein ◽  
Heparin Binding ◽  
Pancreatic Diseases ◽  
Heparin Binding Protein ◽  
Protein Interactome

Human C21orf63 is a Heparin-binding Protein

2009 ◽  
Vol 146 (3) ◽  
pp. 369-373 ◽  
Author(s):  
Kanae Mitsunaga ◽  
Jun Harada-Itadani ◽  
Toshihide Shikanai ◽  
Hiroaki Tateno ◽  
Yuzuru Ikehara ◽  
...  
Keyword(s):  
Binding Protein ◽  
Heparin Binding ◽  
Heparin Binding Protein

Heparin Binding Protein for The Early Diagnosis and Prognosis Of Sepsis In The Emergency Department

Shock ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Konstantinos Katsaros ◽  
Georgios Renieris ◽  
Asimina Safarika ◽  
Evangelia-Maria Adami ◽  
Theologia Gkavogianni ◽  
...  
Keyword(s):  
Emergency Department ◽  
Early Diagnosis ◽  
Binding Protein ◽  
Heparin Binding ◽  
Diagnosis And Prognosis ◽  
Heparin Binding Protein

Dynamic Changes in Heparin-binding Protein as a Prognostic Biomarker in Patients with Sepsis

2020 ◽  
Author(s):  
Qing-Li Dou ◽  
Jiang-Ping Liu ◽  
Wen-Wu Zhang ◽  
Hoi Sin Tong ◽  
Ya-Nan Gu ◽  
...  
Keyword(s):  
Predictive Accuracy ◽  
Binding Protein ◽  
Care Center ◽  
Dynamic Change ◽  
Tertiary Care ◽  
Heparin Binding ◽  
Dynamic Changes ◽  
Multicenter Studies ◽  
Absolute Level ◽  
Heparin Binding Protein

Abstract BACKGROUNDWe aimed to investigate the prognostic value of dynamic changes in heparin-binding protein (HBP) within the first 48 hours of hospital admission in sepsis patients.MethodsWe conducted a prospective observational study in the emergency intensive care unit of a tertiary care center. Patients who met SEPSIS-3 criteria were prospectively enrolled from August 2019 to January 2020. Serum levels of HBP were measured at admission, 24 hours, and 48 hours. Dynamic change in HBP was calculated as a percentage change between admission and 24 hours, and between admission and 48 hours. Accuracies of absolute level of HBP, dynamic change of HBP, and other biomarkers were compared with ROC analysis.ResultsA total of 245 patients were enrolled. After excluding patients not fulfilling the eligibility criteria and those died before 48 hours of admission, 185 patients were included for final analysis, of which 117 had sepsis, 68(36.76%) had septic shock, and 48(30%) died in the hospital. Day 1-HBP was correlated with procalcitonin (r2=0.21, p=0.004). Of all predictors of 30-day mortality, HBP clearance within 48 hours had the highest predictive accuracy (AUC: 0.82), followed by Day 1-HBP (AUC: 0.79), PCT (AUC: 0.75) and HBPc-24(AUC: 0.6). HBPc-48 > -17.14% had an independent impact on 30-day survival after adjusting for age, gender, shock status, and requirement of mechanical ventilation support.ConclusionsHBPc-48 can predict survival in critically ill patients with sepsis and can assist clinicians with risk stratification of these patients. Future multicenter studies are necessary to assess the generalizability of these findings.

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