Tuberculin Skin Testing of Hospital Employees During an Outbreak of Multidrug-Resistant Tuberculosis in Human Immunodeficiency Virus (HIV) -Infected Patients

1992 ◽  
Vol 13 (9) ◽  
pp. 509-510 ◽  
Author(s):  
Jerome I. Tokars ◽  
William R. Jarvis ◽  
Brian R. Edlin ◽  
Samuel W. Dooley ◽  
Michael H. Grieco ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Skin Testing ◽  
Multidrug Resistant ◽  
Tuberculin Skin Testing ◽  
Hospital Employees ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
Immunodeficiency Virus

scholarly journals Outcome of Multidrug-Resistant Tuberculosis in Human Immunodeficiency Virus-Infected Patients

1999 ◽  
Vol 29 (3) ◽  
pp. 553-560 ◽  
Author(s):  
Fabio Franzetti ◽  
Andrea Gori ◽  
Enrico Iemoli ◽  
Paola Meraviglia ◽  
Franco Mainini ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Multidrug Resistant ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
Immunodeficiency Virus

scholarly journals Impact of HIV co-infection on the evolution and transmission of multidrug-resistant tuberculosis

eLife ◽  
2016 ◽  
Vol 5 ◽  
Author(s):  
Vegard Eldholm ◽  
Adrien Rieux ◽  
Johana Monteserin ◽  
Julia Montana Lopez ◽  
Domingo Palmero ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Multidrug Resistant ◽  
Transmission Networks ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
Hiv Epidemic ◽  
Immunodeficiency Virus ◽  
Resistant Strains ◽  
The Impact ◽  
Emergence Of Resistance

The tuberculosis (TB) epidemic is fueled by a parallel Human Immunodeficiency Virus (HIV) epidemic, but it remains unclear to what extent the HIV epidemic has been a driver for drug resistance in Mycobacterium tuberculosis (Mtb). Here we assess the impact of HIV co-infection on the emergence of resistance and transmission of Mtb in the largest outbreak of multidrug-resistant TB in South America to date. By combining Bayesian evolutionary analyses and the reconstruction of transmission networks utilizing a new model optimized for TB, we find that HIV co-infection does not significantly affect the transmissibility or the mutation rate of Mtb within patients and was not associated with increased emergence of resistance within patients. Our results indicate that the HIV epidemic serves as an amplifier of TB outbreaks by providing a reservoir of susceptible hosts, but that HIV co-infection is not a direct driver for the emergence and transmission of resistant strains.

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