scholarly journals High Frequency of Antiretroviral Drug Resistance among HIV‐Infected Adults Receiving First‐Line Highly Active Antiretroviral Therapy in N’Djamena, Chad

2009 ◽  
Vol 49 (1) ◽  
pp. 155-159 ◽  
Author(s):  
Donato Koyalta ◽  
Charlotte Charpentier ◽  
Jatibi Beassamda ◽  
Elisabeth Rey ◽  
Ali Si‐Mohamed ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
High Frequency ◽  
First Line ◽  
Antiretroviral Drug Resistance ◽  
Highly Active ◽  
Antiretroviral Drug

HIV-1 Drug Resistance and Associated Factors Among Adults Failing First-Line Highly Active Antiretroviral Therapy in Ho Chi Minh City, Vietnam

2013 ◽  
Vol 14 (1) ◽  
pp. 34-44 ◽  
Author(s):  
Quang Duy Pham ◽  
Thu Khanh Hoang Huynh ◽  
Tram Thu Luong ◽  
Ton Tran ◽  
Thinh Xuan Vu ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Associated Factors ◽  
Ho Chi Minh City ◽  
First Line ◽  
Highly Active ◽  
Hiv 1

scholarly journals Analysis of HIV- type 1 protease and reverse transcriptase in Brazilian children failing highly active antiretroviral therapy (HAART)

2005 ◽  
Vol 47 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Daisy Maria Machado ◽  
Silvana Cláudia Fernandes ◽  
Regina Célia de Menezes Succi ◽  
Wilton Santos Freire ◽  
Cláudio Sérgio Pannuti ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Antiretroviral Therapy ◽  
Reverse Transcriptase ◽  
Highly Active Antiretroviral Therapy ◽  
Genotypic Resistance ◽  
Highly Active ◽  
Drug Classes ◽  
Antiretroviral Drug ◽  
Genotypic Analysis

The aim of this study was to evaluate the genotypic resistance profiles of HIV-1 in children failing highly active antiretroviral therapy (HAART). Forty-one children (median age = 67 months) receiving HAART were submitted to genotypic testing when virological failure was detected. cDNA was extracted from PBMCs and amplified by nested PCR for the reverse transcriptase and protease regions of the pol gene. Drug resistance genotypes were determined from DNA sequencing. According to the genotypic analysis, 12/36 (33.3%) and 6/36 (16.6%) children showed resistance and possible resistance, respectively, to ZDV; 5/36 (14%) and 4/36 (11.1%), respectively, showed resistance and possible resistance to ddI; 4/36 (11.1%) showed resistance to 3TC and D4T; and 3/36 (8.3%) showed resistance to Abacavir. A high percentage (54%) of children exhibited mutations conferring resistance to NNRTI class drugs. Respective rates of resistance and possible resistance to PIs were: RTV (12.2%, 7.3%); APV (2.4%, 12.1%); SQV(0%, 12.1%); IDV (14.6%, 4.9%), NFV (22%, 4.9%), LPV/RTV (2.4%, 12.1%). Overall, 37/41 (90%) children exhibited virus with mutations related to drug resistance, while 9% exhibited resistance to all three antiretroviral drug classes.

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