Active Tuberculosis in a Healthcare Worker: Are You Ready?

2009 ◽  
Vol 30 (1) ◽  
pp. 80-82 ◽  
Author(s):  
Thomas G. Fraser ◽  
Joan Kowalczyk ◽  
Steven Schmitt ◽  
Jill Bernstein ◽  
Paul Terpeluk ◽  
...  
Keyword(s):  
Tuberculin Skin Test ◽  
Healthcare Worker ◽  
Skin Test ◽  
Latent Tuberculosis ◽  
Control Program ◽  
Positive Tuberculin Skin Test ◽  
Active Tuberculosis ◽  
Test Results ◽  
Potential Benefits ◽  
Skin Test Result

We describe a healthcare worker with a previously positive tuberculin skin test result who developed active tuberculosis. An investigation revealed 280 potential contacts, 3 of whom had positive tuberculin skin test results. Our experience demonstrates the potential benefits of therapy for latent tuberculosis infection as a component of a tuberculosis-control program.

scholarly journals Prevalence and predictors of positive tuberculin skin test results in a research laboratory

2008 ◽  
Vol 41 (4) ◽  
pp. 416-418 ◽  
Author(s):  
Florian H. Pilsczek ◽  
Stefan H.E. Kaufmann
Keyword(s):  
Tuberculin Skin Test ◽  
Skin Test ◽  
Research Laboratory ◽  
Latent Tuberculosis ◽  
Positive Tuberculin Skin Test ◽  
Active Tuberculosis ◽  
Test Results ◽  
Place Of Birth ◽  
High Prevalence ◽  
History Of

Latent tuberculosis was studied in a research laboratory. A prevalence of positive tuberculin skin test results (> 15mm) of 20% was found and the main predictors were place of birth in a foreign country with high prevalence of tuberculosis and a history of contact with patients with untreated active tuberculosis.

scholarly journals Steroids Decrease Prevalence of Positive Tuberculin Skin Test in Rheumatoid Arthritis: Implications on Anti-TNF Therapies

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Shweta Agarwal ◽  
Siddharth Kumar Das ◽  
Girdhar G. Agarwal ◽  
Ragini Srivastava
Keyword(s):  
Rheumatoid Arthritis ◽  
Tuberculin Skin Test ◽  
Skin Test ◽  
Standard Treatment ◽  
Latent Tuberculosis ◽  
Cross Sectional Study ◽  
Positive Tuberculin Skin Test ◽  
Test Results ◽  
Disease Modifying Antirheumatic Drugs ◽  
Cross Sectional

Tuberculin skin test has been used as an indicator of latent tuberculosis in patients with Rheumatoid Arthritis (RA) before administration of biologicals. Effect of Disease modifying antirheumatic drugs (DMARDs) and steroids on the result of tuberculin skin test (TST) may have important implications in interpretation of results of this test.Objectives. To find the prevalence of positive TST in rheumatoid patients and the effect of standard treatment on the results of TST.Method. In this cross-sectional study two hundred and fifty patients of RA above 18 years of age, classified using 1987 ACR criteria for RA, were enrolled from rheumatology outdoor. Demographics, disease activity, disease duration, and therapy were recorded. All patients underwent TST.Results. Fifty-one (20.4%) patients were found to be tuberculin positive. Tuberculin positivity was not affected by MTX intake but it was significantly low in patients with recent steroid intake as compared to patients who had not taken steroids in last 3 months (3% versus 25%,P= 0.002).Conclusion. Prevalence of tuberculin positivity in patients with RA was found to be low. Results were not affected by methotrexate; however tuberculin skin test results in patients with recent use of steroids are likely to be negative.

Infant born to a mother with a positive tuberculin skin test result

1996 ◽  
Vol 10 (1) ◽  
pp. 31-34 ◽  
Author(s):  
Deborah Coody ◽  
Mellissa Denby ◽  
Janet Banks ◽  
Deb Coody ◽  
Kim Connelly Smith ◽  
...  
Keyword(s):  
Tuberculin Skin Test ◽  
Skin Test ◽  
Positive Tuberculin Skin Test ◽  
Tuberculin Skin Test Result ◽  
Skin Test Result ◽  
Test Result

scholarly journals Screening for latent tuberculosis infection: performance of tuberculin skin test and interferon-γ release assays under real-life conditions

2012 ◽  
Vol 71 (11) ◽  
pp. 1791-1795 ◽  
Author(s):  
S Kleinert ◽  
H-P Tony ◽  
K Krueger ◽  
J Detert ◽  
F Mielke ◽  
...  
Keyword(s):  
Risk Factors ◽  
Tuberculin Skin Test ◽  
Skin Test ◽  
Latent Tuberculosis Infection ◽  
Latent Tuberculosis ◽  
Interferon Γ ◽  
Clinical Risk Factors ◽  
Test Results ◽  
Bcg Vaccination ◽  
Rheumatological Disease

ObjectivesTo characterise optimal screening strategies for latent tuberculosis infection (LTBI) prior to the initiation of anti-tumour necrosis factor therapy.MethodsPatients in 62 German rheumatology centres were evaluated for LTBI. Each patient was screened with a tuberculin skin test (TST) and one form of an interferon-γ release assay (IGRA), either TSPOT.TB (TSPOT) or Quantiferon TB Gold (QFT).ResultsA total of 1529 patients with rheumatological disease were tested with a TST, 844 with TSPOT and 685 with QFT. TST was positive in 11.3% (n=173). The prevalence of LTBI was 8.0% when defined as a positive TST and no previous Bacille Calmette-Guérin (BCG) vaccination and 7.9% when based on a positive IGRA. Combining both estimates increased the prevalence of LTBI to 11.1%. Clinical risk factors for LTBI were found in 122 patients (34 with a history of prior TB, 81 close contacts and 27 with suggestive chest x-ray lesions). A compound risk factor (CRF) was defined as the presence of at least one of these three risk factors. Statistical analyses were conducted to examine the association between CRF and LTBI test outcomes. In multivariate analysis, TST was influenced by CRF (OR 6.2; CI 4.08 to 9.44, p<0.001) and BCG vaccination status (OR 2.9; CI 2.00 to 4.35, p<0.001). QFT and TSPOT were only influenced by CRF (QFT: OR 2.6; CI 1.15 to 5.98, p=0.021; TSPOT: OR 8.7; CI 4.83 to 15.82, p<0.001). ORs and the agreement of TST and IGRA test results varied by rheumatological disease.ConclusionLTBI test results in an individual patient need to be considered in the context of prior BCG vaccination and clinical risk factors. In patient populations with low rates of TB incidence and BCG vaccination, the use of both TST and IGRA may maximise sensitivity in detecting LTBI but may also reduce specificity.

scholarly journals False-Positive Tuberculin Skin Test Results Among Low-Risk Healthcare Workers Following Implementation of Fifty-Dose Vials of Purified Protein Derivative

2018 ◽  
Vol 39 (6) ◽  
pp. 750-752 ◽  
Author(s):  
Jeffrey M. Collins ◽  
Mary Hunter ◽  
Wanda Gordon ◽  
Russell R. Kempker ◽  
Henry M. Blumberg ◽  
...  
Keyword(s):  
Tuberculin Skin Test ◽  
Skin Test ◽  
False Positive ◽  
Healthcare Workers ◽  
Large Scale ◽  
The United States ◽  
Positive Tuberculin Skin Test ◽  
Low Risk ◽  
Test Results ◽  
Screening Programs

Following large declines in tuberculosis transmission the United States, large-scale screening programs targeting low-risk healthcare workers are increasingly a source of false-positive results. We report a large cluster of presumed false-positive tuberculin skin test results in healthcare workers following a change to 50-dose vials of Tubersol tuberculin.Infect Control Hosp Epidemiol 2018;39:750–752

scholarly journals Regulatory T Cells Modulate Th17 Responses in Patients with Positive Tuberculin Skin Test Results

2010 ◽  
Vol 201 (1) ◽  
pp. 20-31 ◽  
Author(s):  
Subash Babu ◽  
Sajid Q. Bhat ◽  
N. Pavan Kumar ◽  
V. Kumaraswami ◽  
Thomas B. Nutman
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Tuberculin Skin Test ◽  
Skin Test ◽  
Positive Tuberculin Skin Test ◽  
Test Results
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