scholarly journals The Impact of HIV Tropism on Decreases in CD4 Cell Count, Clinical Progression, and Subsequent Response to a First Antiretroviral Therapy Regimen

2008 ◽  
Vol 46 (10) ◽  
pp. 1617-1623 ◽  
Author(s):  
Laura Waters ◽  
Sundhiya Mandalia ◽  
Paul Randell ◽  
Adrian Wildfire ◽  
Brian Gazzard ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Cell Count ◽  
Clinical Progression ◽  
Cd4 Cell Count ◽  
Therapy Regimen ◽  
Subsequent Response ◽  
Cd4 Cell ◽  
The Impact

scholarly journals Status of immunity against PVB19 in HIV-infected patients according to CD4+cell count, and antiretroviral therapy regimen groups

2014 ◽  
Vol 55 (1) ◽  
pp. 20 ◽  
Author(s):  
Alireza Abdollahi ◽  
Behnaz Mahdaviani ◽  
Mehrnaz Rasoulinejad ◽  
Sara Sheikhbahaei ◽  
Saeed Shoar
Keyword(s):  
Antiretroviral Therapy ◽  
Cell Count ◽  
Cd4 Cell Count ◽  
Therapy Regimen ◽  
Cd4 Cell

The Impact of Episodic CD4 Cell Count-Guided Antiretroviral Therapy on Quality of Life

2008 ◽  
Vol 47 (2) ◽  
pp. 185-193 ◽  
Author(s):  
William J Burman ◽  
Birgit Grund ◽  
Mollie P Roediger ◽  
Gerald Friedland ◽  
Janet Darbyshire ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Antiretroviral Therapy ◽  
Cell Count ◽  
Cd4 Cell Count ◽  
Cd4 Cell ◽  
The Impact

scholarly journals The impact of prescribed opioids on CD4 cell count recovery among HIV-infected patients newly initiating antiretroviral therapy

HIV Medicine ◽  
2016 ◽  
Vol 17 (10) ◽  
pp. 728-739 ◽  
Author(s):  
EJ Edelman ◽  
KS Gordon ◽  
JP Tate ◽  
WC Becker ◽  
K Bryant ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Cell Count ◽  
Cd4 Cell Count ◽  
Cd4 Cell ◽  
The Impact ◽  
Count Recovery

Markov modelling of HIV infection evolution in the HAART era

2009 ◽  
Vol 137 (9) ◽  
pp. 1272-1282 ◽  
Author(s):  
C. BINQUET ◽  
G. Le TEUFF ◽  
M. ABRAHAMOVICZ ◽  
A. MAHBOUBI ◽  
Y. YAZDANPANAH ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Cell Count ◽  
Transition Probabilities ◽  
Real Life ◽  
Clinical Progression ◽  
Hiv Viral Load ◽  
Markov Modelling ◽  
Cd4 Cell Count ◽  
Cd4 Cell ◽  
The Impact

SUMMARYThe aim was to investigate the impact of the main prognostic factors on HIV evolution. A multi-state Markov model was applied in a cohort of 2126 patients to estimate impact of these factors on patients' clinical and immunological evolutions. Clinical progression and immunological deterioration shared most of their prognostic factors: male gender, intravenous drug use, weight loss, low haemoglobin level (<110 g/l), CD8 cell count (<500/mm3) and HIV viral load (>5 log10 copies/ml). Highly active retroviral therapy reduced the risks of clinical progression and immune deterioration whatever patients' CD4 cell count. Risk reductions were 41–60% for protease inhibitor-based and 27–68% for non-nucleoside reverse transcriptase inhibitor-based regimens. Three-year transition probabilities showed that only patients with a CD4 cell count ⩾350 CD4/mm3 could in most cases maintain their immunity. This model provides ‘real life’ transition probabilities from one immunological stage to another, allowing decision analyses that could help determine the beneficial therapeutic strategies for HIV-infected patients.

Failure to achieve a CD4+ cell count response on combination antiretroviral therapy despite consistent viral load suppression

AIDS ◽  
2014 ◽  
Vol 28 (6) ◽  
pp. 919-924 ◽  
Author(s):  
Jemma L. O’Connor ◽  
Colette J. Smith ◽  
Fiona C. Lampe ◽  
Teresa Hill ◽  
Mark Gompels ◽  
...  
Keyword(s):  
Viral Load ◽  
Antiretroviral Therapy ◽  
Cell Count ◽  
Combination Antiretroviral Therapy ◽  
Viral Load Suppression ◽  
Cd4 Cell Count ◽  
Count Response ◽  
Cd4 Cell

scholarly journals Current CD4 Cell Count and the Short‐Term Risk of AIDS and Death before the Availability of Effective Antiretroviral Therapy in HIV‐Infected Children and Adults

2008 ◽  
Vol 197 (3) ◽  
pp. 398-404 ◽  
Author(s):  
David Dunn ◽  
Patrick Woodburn ◽  
Trinh Duong ◽  
Julian Peto ◽  
Andrew Phillips ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Cell Count ◽  
Short Term ◽  
Cd4 Cell Count ◽  
Cd4 Cell

scholarly journals Using record linkage to assess the impact of late presentation for care and treatment on short-term mortality among HIV-infected adults in rural South Africa.

2017 ◽  
Vol 1 (1) ◽  
Author(s):  
Chodziwadziwa Whiteson Kabudula ◽  
Georges Reniers ◽  
Francesc Xavier Gómez-Olivé ◽  
Kathleen Kahn ◽  
Stephen Tollman
Keyword(s):  
South Africa ◽  
Cell Count ◽  
Late Presentation ◽  
Short Term ◽  
Cd4 Cell Count ◽  
Short Term Mortality ◽  
Care And Treatment ◽  
Cd4 Cell ◽  
The Impact ◽  
Rural South Africa

ABSTRACT ObjectivesTo assess the impact of late presentation (CD4 cell count <200 cells/μl at presentation) for care and treatment on short-term mortality (death within a year of presentation) among HIV-infected adults in rural South Africa. ApproachWe applied deterministic and probabilistic record linkage approaches to link adult patients seeking care and treatment for HIV from a health facility between 2007 and 2013 to population under continuous surveillance by the Agincourt Health and Demographic Surveillance System (HDSS) in rural northeast South Africa. The resulting record-linked dataset was thereafter analysed to estimate short-term mortality (death within a year of presentation) differences in late presenters (initial presentation at health facility with CD4 cell count less than 200 cells/μl) and early presenters (presentation with CD4 cell count of 200 or more cells/μl). In the linked dataset, CD4 cell count was extracted from the health facility database where as date of death came from the HDSS database. ResultsA total of 3,553 patients who sought care and treatment for HIV at Bhubhezi clinic between 2007 and 2013 were linked to the Agincourt HDSS surveillance population. Proportion of patients classified as late presenters was 60.9%. Short-term mortality was 8.9% (317/3,553): 11.1% among those who presented late and 5.5 % among those who presented early (P<0.001). ConclusionRecord linkage facilitated the assessment of the impact of late presentation for care and treatment on short-term mortality among HIV-infected adults in rural South Africa. In the population studied, late presentation is high and is contributing to high mortality among people living with HIV. Strategies that would facilitate early presentation are needed in order to reduce mortality among people living with HIV.

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