scholarly journals Clinically Significant Drug Interaction between Tipranavir-Ritonavir and Phenobarbital in an HIV-Infected Subject

2007 ◽  
Vol 45 (12) ◽  
pp. 1654-1655 ◽  
Author(s):  
S. Bonora ◽  
A. Calcagno ◽  
S. Fontana ◽  
A. D'Avolio ◽  
M. Siccardi ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Infected Subject ◽  
Significant Drug Interaction ◽  
Clinically Significant

Inhibition of Hepatic Microsomal Drug Metabolism by the Hydrazines Ro 4-4602, MK 486, and Procarbazine Hydrochloride

1972 ◽  
Vol 50 (7) ◽  
pp. 721-724 ◽  
Author(s):  
Norman R. Bade ◽  
Stuart M. MacLeod ◽  
Kenneth W. Renton
Keyword(s):  
Drug Interaction ◽  
Drug Metabolism ◽  
Sleeping Time ◽  
Hydrazine Derivatives ◽  
Significant Drug Interaction ◽  
Microsomal Drug Metabolism ◽  
Clinically Significant ◽  
Hepatic Biotransformation

Preliminary experiments were undertaken to examine the effect of three hydrazine derivatives, viz. Ro 4-4602, MK 486, and procarbazine hydrochloride, on hepatic microsomal drug metabolism in rats. All three compounds when given as pretreatment significantly prolonged pentobarbital sleeping time. In vitro, the hepatic microsomal N-demethylation of aminopyrine was inhibited. It is concluded that all three drugs are possible sources of clinically significant drug interaction when administered in combination with other agents which undergo hepatic biotransformation.

ASSESSMENT OF DRUG INTERACTIONS IN OUTPATIENT PRESCRIPTIONS IN HUE UNIVERSITY OF MEDICINE AND PHARMACY HOSPITAL

2018 ◽  
Vol 8 (5) ◽  
pp. 26-36
Author(s):  
Phuong Vo Thi Hong ◽  
Hien Nguyen Thi
Keyword(s):  
Drug Interaction ◽  
Proton Pump Inhibitor ◽  
Drug Interactions ◽  
Descriptive Study ◽  
Management Guideline ◽  
Cross Sectional ◽  
Significant Drug Interaction ◽  
Clinically Significant ◽  
Multiple Symptoms ◽  
Outpatient Prescriptions

Background: The combination of drugs in treatment is inevitable, especially in multiple diseases and multiple symptoms. This is the leading cause of occurrence of drug - drug interactions. Objectives: (1) To identify clinically significant drug interactions in outpatient prescriptions in Hue University of Medicine and Pharmacy Hospital, (2) To build a management guideline of clinically significant drug interactions in Hue University of Medicine and Pharmacy Hospital. Materials and methods: 5338 outpatient prescriptions were collected from Pharmacy Faculty – Hue University of Medicine and Pharmacy Hospital from 1st to 31st October 2017, using cross-sectional descriptive study method. Results and Conclusion: The list of 20 clinically significant drug interaction pairs was identified and a management guideline for each interacting pair was built. The prevalence of prescriptions with drug interactions was 6.7%. The most commonly identified drug interaction pair was clopidogrel and proton pump inhibitor (1.59%). The occurrence of drug interactions increased with increase in the age of patients and the number of drugs prescribed (p < 0.05). Key words: combination of drugs, drug interaction, clinically significant, prescription, outpatient

scholarly journals Clinically significant drug interaction: letermovir and voriconazole

2019 ◽  
Vol 75 (3) ◽  
pp. 775-777 ◽  
Author(s):  
Arianne Duong ◽  
Ania Sweet ◽  
Rupali Jain ◽  
Joshua A Hill ◽  
Steven A Pergam ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Significant Drug Interaction ◽  
Clinically Significant

Theophylline and Verapamil: Clinically Significant Drug Interaction

1997 ◽  
Vol 13 (6) ◽  
pp. 241-243
Author(s):  
Luella Bangura ◽  
Mark A Malesker ◽  
Naresh A Dewan
Keyword(s):  
Drug Interaction ◽  
Chest Pain ◽  
Adverse Effects ◽  
Clinical Significance ◽  
Sudden Onset ◽  
Review Of The Literature ◽  
Theophylline Clearance ◽  
Significant Drug Interaction ◽  
Case Summary ◽  
Clinically Significant

Objective: To report and describe a case of verapamil interacting with theophylline. Case Summary: A 33-year-old white man with bronchial asthma was admitted for evaluation of sudden onset of chest pain. During hospitalization, verapamil 120 mg/d was added to the theophylline regimen (600 mg bid). The patient's requirement for theophylline decreased by 50% after the initiation of verapamil. Discussion: A review of the literature indicated that concomitant verapamil may reduce theophylline clearance by 12–23%. Other reports suggest that the degree of this interaction is of much smaller magnitude and clinically insignificant. Conclusions: Although the most recent FDA labeling guidelines for theophylline mention verapamil as a documented source of drug interaction with theophylline, many clinicians may not realize the potential clinical significance. Therefore, theophylline concentrations should be monitored in patients receiving both theophylline and verapamil, even in the absence of adverse effects.

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