Clinically Significant Drug Interaction Between Clotrimazole and Tacrolimus in Pancreas Transplant Recipients and Associated Risk of Allograft Rejection

2016 ◽  
Vol 36 (3) ◽  
pp. 335-341 ◽  
Author(s):  
Chris W. Viesselmann ◽  
Jillian L. Descourouez ◽  
Margaret R. Jorgenson ◽  
Nancy A. Radke ◽  
Jon S. Odorico
Keyword(s):  
Drug Interaction ◽  
Allograft Rejection ◽  
Pancreas Transplant ◽  
Transplant Recipients ◽  
Significant Drug Interaction ◽  
Clinically Significant

Inhibition of Hepatic Microsomal Drug Metabolism by the Hydrazines Ro 4-4602, MK 486, and Procarbazine Hydrochloride

1972 ◽  
Vol 50 (7) ◽  
pp. 721-724 ◽  
Author(s):  
Norman R. Bade ◽  
Stuart M. MacLeod ◽  
Kenneth W. Renton
Keyword(s):  
Drug Interaction ◽  
Drug Metabolism ◽  
Sleeping Time ◽  
Hydrazine Derivatives ◽  
Significant Drug Interaction ◽  
Microsomal Drug Metabolism ◽  
Clinically Significant ◽  
Hepatic Biotransformation

Preliminary experiments were undertaken to examine the effect of three hydrazine derivatives, viz. Ro 4-4602, MK 486, and procarbazine hydrochloride, on hepatic microsomal drug metabolism in rats. All three compounds when given as pretreatment significantly prolonged pentobarbital sleeping time. In vitro, the hepatic microsomal N-demethylation of aminopyrine was inhibited. It is concluded that all three drugs are possible sources of clinically significant drug interaction when administered in combination with other agents which undergo hepatic biotransformation.

scholarly journals Low CD4/CD8 Ratio in Bronchus-Associated Lymphoid Tissue Is Associated with Lung Allograft Rejection

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
K. V. Shenoy ◽  
C. Solomides ◽  
F. Cordova ◽  
T. J. Rogers ◽  
D. Ciccolella ◽  
...  
Keyword(s):  
Acute Rejection ◽  
B Cell ◽  
Allograft Rejection ◽  
Lymphoid Tissue ◽  
Rejection Rate ◽  
First Year ◽  
Transplant Recipients ◽  
Clinically Significant ◽  
Cell Subpopulations ◽  
One Year

Background. Bronchus-associated lymphoid tissue (BALT) has been associated with lung allograft rejection in rat transplant models. In human transplant recipients, BALT has not been linked to clinically significant rejection. We hypothesize that the immunohistochemical composition of BALT varies with the presence of acute lung allograft rejection.Methods. We retrospectively examined 40 human lung allograft recipients transplanted from 3/1/1999 to 6/1/2008. Patients were grouped by frequency and severity of acute rejection based on International Society of Heart Lung Transplant (ISHLT) criteria. Transbronchial biopsies were reviewed for BALT by a blinded pathologist. BALT if present was immunohistochemically stained to determine T-and B-cell subpopulations.Results. BALT presence was associated with an increased frequency of acute rejection episodes in the first year after transplantation. Patients with a lower CD4/CD8 ratio had an increased rejection rate; however, BALT size or densities of T-cell and B-cell subpopulations did not correlate with rejection rate.Conclusion. The presence of BALT is associated with an increased frequency of rejection one year after transplant. The lower the CD4/CD8 ratio, the more acute rejection episodes occur in the first year after transplantation. The immunohistochemical composition of BALT may predict patients prone to frequent episodes of acute cellular rejection.

scholarly journals Clinically Significant Drug Interaction between Tipranavir-Ritonavir and Phenobarbital in an HIV-Infected Subject

2007 ◽  
Vol 45 (12) ◽  
pp. 1654-1655 ◽  
Author(s):  
S. Bonora ◽  
A. Calcagno ◽  
S. Fontana ◽  
A. D'Avolio ◽  
M. Siccardi ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Infected Subject ◽  
Significant Drug Interaction ◽  
Clinically Significant

Clinically Significant Drug−Drug Interaction Between Tacrolimus and Phenobarbital

2010 ◽  
Vol 23 (6) ◽  
pp. 585-589 ◽  
Author(s):  
Nida Siddiqi ◽  
Kwaku Marfo
Keyword(s):  
Drug Interaction ◽  
Renal Transplant ◽  
Drug Interactions ◽  
Transplant Rejection ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Patient Identification ◽  
Clinically Significant ◽  
Trough Levels ◽  
Renal Transplant Rejection

Purpose: The case of a 57-year-old male who experienced acute renal transplant rejection due to subtherapeutic tacrolimus levels as a result of drug interaction with phenobarbital. Summary: Drug interactions with tacrolimus due to its metabolism through the CYP 450 3A4 enzymatic pathway have led to several reports of altered tacrolimus levels, which can lead to acute rejection in renal transplant recipients. We describe the case of a 57-year-old male initiated on immunosuppressive therapy with tacrolimus in addition to his anticonvulsant medications. Conclusion: Upon tacrolimus dose increases, discontinuation of carbamazepine, and minimization of phenobarbital dose, effective tacrolimus trough levels were achieved in our patient. Identification and elimination of such drug−drug interactions is necessary to assure adequate immunosuppression in renal transplant recipients.

ASSESSMENT OF DRUG INTERACTIONS IN OUTPATIENT PRESCRIPTIONS IN HUE UNIVERSITY OF MEDICINE AND PHARMACY HOSPITAL

2018 ◽  
Vol 8 (5) ◽  
pp. 26-36
Author(s):  
Phuong Vo Thi Hong ◽  
Hien Nguyen Thi
Keyword(s):  
Drug Interaction ◽  
Proton Pump Inhibitor ◽  
Drug Interactions ◽  
Descriptive Study ◽  
Management Guideline ◽  
Cross Sectional ◽  
Significant Drug Interaction ◽  
Clinically Significant ◽  
Multiple Symptoms ◽  
Outpatient Prescriptions

Background: The combination of drugs in treatment is inevitable, especially in multiple diseases and multiple symptoms. This is the leading cause of occurrence of drug - drug interactions. Objectives: (1) To identify clinically significant drug interactions in outpatient prescriptions in Hue University of Medicine and Pharmacy Hospital, (2) To build a management guideline of clinically significant drug interactions in Hue University of Medicine and Pharmacy Hospital. Materials and methods: 5338 outpatient prescriptions were collected from Pharmacy Faculty – Hue University of Medicine and Pharmacy Hospital from 1st to 31st October 2017, using cross-sectional descriptive study method. Results and Conclusion: The list of 20 clinically significant drug interaction pairs was identified and a management guideline for each interacting pair was built. The prevalence of prescriptions with drug interactions was 6.7%. The most commonly identified drug interaction pair was clopidogrel and proton pump inhibitor (1.59%). The occurrence of drug interactions increased with increase in the age of patients and the number of drugs prescribed (p < 0.05). Key words: combination of drugs, drug interaction, clinically significant, prescription, outpatient

scholarly journals Clinically significant drug interaction: letermovir and voriconazole

2019 ◽  
Vol 75 (3) ◽  
pp. 775-777 ◽  
Author(s):  
Arianne Duong ◽  
Ania Sweet ◽  
Rupali Jain ◽  
Joshua A Hill ◽  
Steven A Pergam ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Significant Drug Interaction ◽  
Clinically Significant
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