Use of Decolonization to Prevent Staphylococcal Infections in Various Healthcare Settings: Results of an Emerging Infections Network Survey

2007 ◽  
Vol 28 (9) ◽  
pp. 1111-1113 ◽  
Author(s):  
Sarah Klizas West ◽  
Melissa S. Plantenga ◽  
Larry J. Strausbaugh ◽  
Keyword(s):  
Staphylococcus Aureus ◽  
Infectious Diseases ◽  
Infection Control ◽  
Surgical Procedures ◽  
Nosocomial Transmission ◽  
Emerging Infections ◽  
Methicillin Resistant ◽  
Staphylococcal Infections ◽  
Healthcare Settings ◽  
Elective Surgical Procedures

Less than 20% of infectious diseases consultants work in hospitals that routinely employ decolonization therapy for individuals with staphylococcal carriage undergoing elective surgical procedures or for infection control efforts to limit nosocomial transmission of methicillin-resistantStaphylococcus aureus(MRSA). However, infectious diseases consultants frequently encounter patients with recurrent MRSA furunculosis and attempt to decolonize them.

scholarly journals Staphylococcus aureus bacteraemia: The Australia New Zealand Cooperative on Outcomes in Staphylococcal Sepsis (ANZCOSS)

2008 ◽  
Vol 29 (3) ◽  
pp. 147
Author(s):  
John Turnidge ◽  
Despina Kotsanas
Keyword(s):  
Staphylococcus Aureus ◽  
Intensive Care ◽  
New Zealand ◽  
Infectious Diseases ◽  
Infection Control ◽  
Intensive Care Units ◽  
Sepsis Syndrome ◽  
Methicillin Resistant ◽  
Life Threatening ◽  
Resistant Strains

Staphylococcus aureus is such a common organism, both as a coloniser and cause of infection in humans, that it is easy to take it for granted. Microbiologists, infectious diseases specialists and infection control practitioners deal with the organism on a regular basis, from screening for methicillin-resistant strains (MRSA) in asymptomatic carriers to treating patients with life-threatening sepsis syndrome in intensive care units.

scholarly journals Inference and control of the nosocomial transmission of methicillin-resistant Staphylococcus aureus

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Sen Pei ◽  
Flaviano Morone ◽  
Fredrik Liljeros ◽  
Hernán Makse ◽  
Jeffrey L Shaman
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Substantial Improvement ◽  
Nosocomial Transmission ◽  
Contact Tracing ◽  
Accurate Estimation ◽  
Methicillin Resistant ◽  
Healthcare Settings ◽  
Heuristic Strategies ◽  
Number Of Patients

Methicillin-resistant Staphylococcus aureus (MRSA) is a continued threat to human health in both community and healthcare settings. In hospitals, control efforts would benefit from accurate estimation of asymptomatic colonization and infection importation rates from the community. However, developing such estimates remains challenging due to limited observation of colonization and complicated transmission dynamics within hospitals and the community. Here, we develop an inference framework that can estimate these key quantities by combining statistical filtering techniques, an agent-based model, and real-world patient-to-patient contact networks, and use this framework to infer nosocomial transmission and infection importation over an outbreak spanning 6 years in 66 Swedish hospitals. In particular, we identify a small number of patients with disproportionately high risk of colonization. In retrospective control experiments, interventions targeted to these individuals yield a substantial improvement over heuristic strategies informed by number of contacts, length of stay and contact tracing.

Intersection of HIV and community-associated methicillin-resistant Staphylococcus aureus

2020 ◽  
Vol 15 (1) ◽  
pp. 53-65
Author(s):  
Kyle J Popovich
Keyword(s):  
Staphylococcus Aureus ◽  
Infection Control ◽  
Infection Prevention ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Control Strategies ◽  
Community Settings ◽  
Methicillin Resistant ◽  
The Past ◽  
Healthcare Settings ◽  
Increased Risk

The epidemiology of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has evolved over the past approximately 20 years, with certain populations appearing to have disproportionate risk. Of concern is the potential worsening of S. aureus infections in light of the continued opioid crisis. This review will discuss how CA-MRSA has significantly impacted HIV-infected individuals and address additional factors and populations that are associated with increased risk for MRSA. It will review therapeutic options and infection control strategies as well as highlight how whole genome sequencing can be used to extend traditional epidemiologic analysis and ultimately, inform infection prevention efforts. Continued work identifying those at the highest risk for MRSA, what the best infection prevention settings are in community settings and how to effectively implement and target these strategies is needed. Ultimately, infection control efforts will likely need to extend beyond healthcare settings to effectively and sustainably reduce MRSA infections.

Genomic Epidemiology of Invasive Methicillin-Resistant Staphylococcus aureus Infections Among Hospitalized Individuals in Ontario, Canada

2020 ◽  
Vol 222 (12) ◽  
pp. 2071-2081 ◽  
Author(s):  
Jennifer L Guthrie ◽  
Sarah Teatero ◽  
Sotaro Hirai ◽  
Alex Fortuna ◽  
Daniel Rosen ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Demographic Data ◽  
Public Health Practice ◽  
Acid Resistance ◽  
Fold Increase ◽  
High Genetic Diversity ◽  
Methicillin Resistant ◽  
Genomic Epidemiology ◽  
Healthcare Settings

Abstract Background Prevention and control of methicillin-resistant Staphylococcus aureus (MRSA) infections remain challenging. In-depth surveillance integrating patient and isolate data can provide evidence to better inform infection control and public health practice. Methods We analyzed MRSA cases diagnosed in 2010 (n = 212) and 2016 (n = 214) by hospitals in Ontario, Canada. Case-level clinical and demographic data were integrated with isolate characteristics, including antimicrobial resistance (AMR), classic genotyping, and whole-genome sequencing results. Results Community-associated MRSA (epidemiologically defined) increased significantly from 23.6% in 2010 to 43.0% in 2016 (P < .001). The MRSA population structure changed over time, with a 1.5× increase in clonal complex (CC)8 strains and a concomitant decrease in CC5. The clonal shift was reflected in AMR patterns, with a decrease in erythromycin (86.7% to 78.4%, P = .036) and clindamycin resistance (84.3% to 47.9%, P < .001) and a >2-fold increase in fusidic acid resistance (9.0% to 22.5%, P < .001). Isolates within both CC5 and CC8 were relatively genetically diverse. We identified 6 small genomic clusters—3 potentially related to transmission in healthcare settings. Conclusions Community-associated MRSA is increasing among hospitalized individuals in Ontario. Clonal shifting from CC5 to CC8 has impacted AMR. We identified a relatively high genetic diversity and limited genomic clustering within these dominant CCs.

Nosocomial Transmission of Methicillin-Resistant Staphylococcus aureus: A Blinded Study to Establish Baseline Acquisition Rates

2003 ◽  
Vol 24 (6) ◽  
pp. 415-421 ◽  
Author(s):  
Joel T. Fishbain ◽  
Joseph C. Lee ◽  
Honghung D. Nguyen ◽  
Jeffery A. Mikita ◽  
Cecilia P. Mikita ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Transmission Rate ◽  
Tertiary Care ◽  
Pediatric Intensive Care ◽  
Nosocomial Transmission ◽  
Surveillance Culture ◽  
Care Hospital ◽  
Average Hospital ◽  
Methicillin Resistant ◽  
History Of

AbstractObjective:To define the extent of nosocomial transmission of methicillin-resistant Staphylococcus aureus (MRSA) in patients admitted to a tertiary-care hospital.Design:A blinded, prospective surveillance culture study of patients admitted to the hospital to determine the transmission (acquisition) rate of MRSA Risk factors associated with the likelihood of MRSA colonization on admission were investigated.Setting:Tertiary-care military medical facility.Participants:All patients admitted to the medicine, surgery, and pediatric wards, and to the medical, surgical, and pediatric intensive care units were eligible for inclusion.Results:Five hundred thirty-five admission and 374 discharge samples were collected during the study period. One hundred forty-one patients were colonized with methicillin-susceptible S. aureus (MSSA) and 20 patients (3.7%) were colonized with MRSA on admission. Of the 354 susceptible patients, 6 acquired MRSA during the study for a transmission rate of 1.7%. Patients colonized with MRSA on admission were more likely to be older than non-colonized or MSSA-colonized patients, to have received antibiotics within the past year, to have been hospitalized within the prior 3 years, or to have a known history of MRSA. Patients acquiring MRSA had an average hospital stay of 17.7 days compared with 5.3 days for those who did not acquire MRSA. Pulsed-field gel electrophoresis of the 6 MRSA isolates from patients who acquired MRSA revealed 4 distinct band patterns.Conclusions:Most patients colonized with MRSA were identified on admission samples. Surveillance cultures of patients admitted may help to prevent MRSA transmission and infection.

scholarly journals Methicillin-Resistant Staphylococcus aureus Recovered from Healthcare- and Community-Associated Infections in Egypt

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Mohamed Abdel-Maksoud ◽  
Mona El-Shokry ◽  
Ghada Ismail ◽  
Soad Hafez ◽  
Amani El-Kholy ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Infection Control ◽  
Continuous Monitoring ◽  
Inhibitory Concentration ◽  
Methicillin Resistant ◽  
Inducible Clindamycin Resistance ◽  
The Past ◽  
Mrsa Strains ◽  
Healthcare Associated ◽  
Over Time

Background. Methicillin-resistant Staphylococcus aureus (MRSA) has created significant epidemiological, infection-control, and therapeutic management challenges during the past three decades. Aim. To analyze the pattern of resistance of healthcare- and community-associated MRSA in Egypt and the trend of resistance of HA-MRSA over time (2005–2013). Methods. MRSA isolates were recovered from healthcare-associated (HA) and community-associated (CA) Staphylococcus aureus (S. aureus) infections. They were tested against 11 antimicrobial discs and the minimal inhibitory concentration (MIC) of vancomycin was determined. Inducible clindamycin resistance (iMLSB) was also screened using D-test. Findings. Of 631 S. aureus, MRSA was identified in 343 (76.6%) and 21 (11.5%) of HA and CA S. aureus isolates, respectively. The proportion of HA-MRSA increased significantly from 48.6% in 2005 to 86.8% in 2013 (p value < 0.001). Multidrug resistance (MDR) was observed in 85.8% of HA-MRSA and 48.6% of CA-MRSA. Vancomycin intermediate resistant S. aureus (VISA) was detected in 1.2% of HA-MRSA and none was detected in CA-MRSA. Among HA-MRSA strains, 5.3% showed iMLSB compared to 9.5% among CA-MRSA. Conclusion. The upsurge of the prevalence rates of HA-MRSA over time is alarming and urges for an effective infection control strategy and continuous monitoring of antimicrobial use.

scholarly journals Prevalence of Methicillin Resistant Staphylococcus Aureus In Khwaja Yunus Ali Medical College Hospital

KYAMC Journal ◽  
2017 ◽  
Vol 7 (1) ◽  
pp. 673-677
Author(s):  
Abdullah Akhtar Ahmed ◽  
Shakhaowat Hossain ◽  
Babul Aktar ◽  
Nusrat Akhtar Juyee ◽  
SM Ali Hasan
Keyword(s):  
Staphylococcus Aureus ◽  
Tract Infection ◽  
Respiratory Tract ◽  
Infection Control ◽  
Respiratory Tract Infection ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Throat Swab ◽  
College Hospital ◽  
Methicillin Resistant ◽  
Medical College

Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of healthcare-associated infections. To combat the challenge of life threatening MRSA remains a primary focus of most hospital infection control programs6. This study is undertaken in Khwaja Yunus Ali Medical College Hospital to identify the MRSA for determination of its prevalence and is considered a component of an infection control program in many countries5.Methods: Three hundred seventy hospitalized patients of surgery and medicine departments were studied during 2015. Clinical information of the patients and their pus, wound swab, sputum, throat swab and CSF were cultured.Results: Out of 370 patients, pus and wound swab of 217 (59%) had wound infection, sputum and throat swab of 141 had respiratory tract infection (38%) and CSF of 12 (3.2%) had meningitis were aseptically collected and cultured. Staphylococcus aureus were isolated in 51% cases and out of them MRSA was identified in 72 (73%) cases. MRSA isolated in 50% cases of meningitis, 49% cases of respiratory tract infection and 29% cases of wound infection.Conclusion: Methicillin-resistant Staphylococcus aureus appeared as a common cause of major illness and death and impose serious economic costs on patients and hospitals of our area like other developing countries. Detection of MRSA was associated with more severe clinical presentation.KYAMC Journal Vol. 7, No.-1, Jul 2016, Page 673-677

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