scholarly journals Early Emergence of Ganciclovir-Resistant Human Cytomegalovirus Strains in Children with Primary Combined Immunodeficiency

1998 ◽  
Vol 178 (2) ◽  
pp. 535-538 ◽  
Author(s):  
D. G. Wolf ◽  
I. Yaniv ◽  
A. Honigman ◽  
I. Kassis ◽  
T. Schonfeld ◽  
...  
Keyword(s):  
Human Cytomegalovirus ◽  
Combined Immunodeficiency ◽  
Early Emergence

scholarly journals Emergence of Multiple Human Cytomegalovirus Ganciclovir-Resistant Mutants with Deletions and Substitutions within the UL97 Gene in a Patient with Severe Combined Immunodeficiency

2001 ◽  
Vol 45 (2) ◽  
pp. 593-595 ◽  
Author(s):  
Dana G. Wolf ◽  
Isaac Yaniv ◽  
Shai Ashkenazi ◽  
Alik Honigman
Keyword(s):  
Human Cytomegalovirus ◽  
Severe Combined Immunodeficiency ◽  
Combined Immunodeficiency ◽  
Ganciclovir Therapy ◽  
Resistant Mutants ◽  
Ul97 Gene

ABSTRACT Infection with multiple ganciclovir-resistant human cytomegalovirus mutants, containing different substitutions and deletions in the UL97 gene, was found in a patient with severe combined immunodeficiency (SCID) within 3 weeks of ganciclovir therapy. A novel 11-codon deletion at positions 590 to 600 was identified. These unique findings may be related to the nature of the immunodeficiency in the SCID patient.

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